Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding V(H)81X-expressing B cells.

scientific article published on 11 May 2015

Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding V(H)81X-expressing B cells. is …
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scholarly articleQ13442814

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P819ADS bibcode2015NatCo...6.7077G
P6179Dimensions Publication ID1053034579
P356DOI10.1038/NCOMMS8077
P698PubMed publication ID25959489
P5875ResearchGate publication ID276147048

P50authorSofia AnderssonQ50855544
Inga-Lill MartenssonQ57512325
Ola GrimsholmQ57832618
Alessandro CamponeschiQ86017371
P2093author name stringDongfeng Chen
Susanna Cardell
Haixia Chen
Ulf Yrlid
Giljun Park
Inger Gjertsson
Angelina I Bernardi
Alessandra De Riva
Weicheng Ren
Berglind Bergmann
Nina Höök
Anneli Strömberg
P2860cites workIMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysisQ24646236
Molecular programming of B cell memoryQ26829944
B-cell tolerance checkpoints in health and autoimmunityQ28296605
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunityQ28507088
Follicular helper CD4 T cells (TFH)Q29615063
Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotypeQ39180411
Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions.Q39866994
The immunopathology of joint inflammation in rheumatoid arthritisQ39941762
Genetic and structural evidence for antigen selection of anti-DNA antibodies.Q40661152
V-region directed selection in differentiating B lymphocytesQ40872767
Generation and function of natural self-reactive B lymphocytesQ41146462
Diversity in the CDR3 region of V(H) is sufficient for most antibody specificitiesQ41753346
Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcriptsQ41813717
N-linked glycosylation selectively regulates autonomous precursor BCR functionQ42973099
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut floraQ44218058
Virus-induced autoantibody response to a transgenic viral antigenQ45851561
Diversity among memory B cells: origin, consequences, and utility.Q46918689
The pre-B cell receptor: turning autoreactivity into self-defenseQ47398811
Spontaneous formation of germinal centers in autoimmune mice.Q47574161
Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomasQ48166985
Developmentally controlled selection of antibody genes: Characterization of individual VH7183 genes and evidence for stage-specific somatic diversificationQ48190531
Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.Q50731194
Cloning and expression of murine Ig genes from single B cells.Q52908841
The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.Q55053665
Systemic lupus erythematosusQ71046919
Changes in the VH Gene Repertoire of Developing Precursor B Lymphocytes in Mouse Bone Marrow Mediated by the Pre-B Cell ReceptorQ73767616
Negative selection at the pre-BCR checkpoint elicited by human mu heavy chains with unusual CDR3 regionsQ73923498
VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locusQ74261418
Anti-DNA autoantibodies: a puzzle of autoimmune phenomenaQ78214764
Development of Autoantibodies before the Clinical Onset of Systemic Lupus ErythematosusQ79171865
Censoring of autoreactive B cell development by the pre-B cell receptorQ81485516
Surrogate light chain is required for central and peripheral B-cell tolerance and inhibits anti-DNA antibody production by marginal zone B cellsQ86420041
T follicular helper cell dynamics in germinal centersQ30573316
Requirement for complement in antibody responses is not explained by the classic pathway activator IgMQ34046071
Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.Q34063153
Germinal centersQ34245271
Follicular dendritic cells as accessory cellsQ34274623
High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strainsQ34566686
Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell SubsetsQ35097452
Autoantibodies: Focus on anti-DNA antibodiesQ35106998
Selection of immunoglobulin variable regions in autoimmunity to DNAQ35499782
Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centersQ35669109
Pathophysiology of T follicular helper cells in humans and miceQ35695090
Efficient generation of B lymphocytes by recognition of self-antigensQ35825782
A germinal center–independent pathway generates unswitched memory B cells early in the primary responseQ35825984
Mechanisms of B cell autoimmunity in SLE.Q35840704
Cellular and genetic mechanisms of self tolerance and autoimmunityQ36148399
The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoireQ36184410
Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotidesQ36186840
Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursorsQ36775342
The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation.Q36822711
Regulation of autoreactive antibodiesQ36925329
RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetesQ37019638
Sites and stages of autoreactive B cell activation and regulation.Q37058621
Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosusQ37277161
Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studiesQ37332754
What happens before the onset of rheumatoid arthritis?Q37443729
Tolerance checkpoints in B-cell development: Johnny B good.Q37588588
New insights into the differentiation and function of T follicular helper cells.Q37621244
Checkpoints in lymphocyte development and autoimmune diseaseQ37657051
Influence of microbial environment on autoimmunity.Q37657060
Plugging the leaky pre-B cell receptorQ37678735
T cells and follicular dendritic cells in germinal center B-cell formation and selection.Q37781390
Self-recognition and clonal selection: autoreactivity drives the generation of B cellsQ37991451
The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.Q38062588
The imperfect control of self-reactive germinal center B cellsQ38200841
The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cellsQ38355683
P407language of work or nameEnglishQ1860
P304page(s)7077
P577publication date2015-05-11
P1433published inNature CommunicationsQ573880
P1476titleAbsence of surrogate light chain results in spontaneous autoreactive germinal centres expanding V(H)81X-expressing B cells
P478volume6

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cites work (P2860)
Q48369131Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected repertoires.
Q47561660Autoimmunity checkpoints as therapeutic targets in B cell malignancies
Q50660287CD21(-/low) B cells in human blood are memory cells.
Q64065258Dissecting Integrin Expression and Function on Memory B Cells in Mice and Humans in Autoimmunity
Q46364067Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia.
Q47118310Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations
Q59333236The Role of the Pre-B Cell Receptor in B Cell Development, Repertoire Selection, and Tolerance

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