Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches

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Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.EXER.2016.06.018
P932PMC publication ID5199622
P698PubMed publication ID27373973

P2093author name stringVincent M Monnier
Xingjun Fan
Jeremy Whitson
P2860cites workEales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreousQ72993445
Cataract development in gamma-glutamyl transpeptidase-deficient miceQ73235394
Modelling cortical cataractogenesis XXIV: uptake by the lens of glutathione injected into the ratQ73317098
Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epitheliumQ73519368
Kinetic and pharmacological analysis of L-[35S]cystine transport into rat brain synaptosomesQ73669443
Determination of glutathione, cysteine and N-acetylcysteine in rabbit eye tissues using high-performance liquid chromatography and post-column derivatization with 5,5'-dithiobis(2-nitrobenzoic acid)Q73703538
Importance of vitreous liquefaction in age-related cataractQ75201651
An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataractQ77759968
The stiffness of human cataract lenses is a function of both age and the type of cataractQ80744159
Massive increase in the stiffness of the human lens nucleus with age: the basis for presbyopia?Q81192129
Glutamate induces glutathione efflux mediated by glutamate/aspartate transporter in retinal cell culturesQ82907231
Molecular identification and cellular localisation of GSH synthesis, uptake, efflux and degradation pathways in the rat ciliary bodyQ46282210
Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cellsQ46411830
Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporteQ46426150
Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epitheliumQ46826457
Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulationsQ46943807
Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.Q48482631
Effect of ammonia on GABA uptake and release in cultured astrocytes.Q53701723
Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cellsQ53709826
Molecular identification and characterisation of the glycine transporter (GLYT1) and the glutamine/glutamate transporter (ASCT2) in the rat lens.Q54606152
Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathioneQ66909758
Protein-thiol mixed disulfides in human lensQ67992804
Glutathione levels in human lens: regional distribution in different forms of cataractQ68716193
The role of protein-thiol mixed disulfides in cataractogenesisQ68859339
Transport of L-glutamic acid and L-glutamine and their incorporation into lenticular glutathioneQ69664993
Transport and steady-state concentration of plasma proteins in the vitreous humor of the chicken embryo: implications for the mechanism of eye growth during early developmentQ70029508
Localization of gamma-glutamyl transpeptidase in rabbit lens, ciliary process and corneaQ70043959
Further studies on the dynamic changes of glutathione and protein-thiol mixed disulfides in H2O2 induced cataract in rat lenses: distributions and effect of agingQ70867347
Nuclear light scattering, disulfide formation and membrane damage in lenses of older guinea pigs treated with hyperbaric oxygenQ72332164
Effects of oxidized glutathione and reduced glutathione on the barrier function of the corneal endotheliumQ72504988
Lenticular glutathione synthesis: rate-limiting factors in its regulation and declineQ72568812
Aging and age-related diseases of the ocular lens and vitreous bodyQ26828962
Mechanisms of glutamate transportQ26830761
Excitatory amino acid transporters: roles in glutamatergic neurotransmissionQ27011208
Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae.Q27933589
Redox regulation in the lensQ28191230
Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6Q28201669
The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNSQ28265451
Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levelsQ28265776
The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesisQ28485409
Molecular characterization of the cystine/glutamate exchanger and the excitatory amino acid transporters in the rat lensQ28581354
Coincident loss of mitochondria and nuclei during lens fiber cell differentiationQ30995170
Mapping of glutathione and its precursor amino acids reveals a role for GLYT2 in glycine uptake in the lens coreQ33303981
Regulation of hepatic glutathione synthesis: current concepts and controversies.Q33672601
Glutathione: a vital lens antioxidantQ33913849
Thiol regulation in the lensQ33913855
Age-related nuclear cataract: a lens transport problemQ34022343
The biochemistry of agingQ34065628
Aqueous humor dynamics: a reviewQ34162577
Oxidative damage and the prevention of age-related cataractsQ34186273
The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.Q34279067
Molecular mechanisms of cystine transportQ34439533
Functional re-evaluation of the putative glutathione transporters, RcGshT and RsGshTQ34471755
Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleusQ34552658
Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domainQ34810742
The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataractsQ34975525
Loss of thiol repair systems in human cataractous lensesQ35012811
Anatomic alterations in aging and age-related diseases of the eye.Q35066318
Enzymes of the gamma-glutamyl cycle in the ciliary body and lensQ35109458
Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse modelQ35130805
Gamma-glutamyl transpeptidase: redox regulation and drug resistanceQ35298939
Glutathione metabolism during aging and in Alzheimer diseaseQ35832987
Age-related nuclear cataract-oxidation is the key.Q36111043
Divergent effects of compounds on the hydrolysis and transpeptidation reactions of γ-glutamyl transpeptidaseQ36123399
The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypesQ36236149
Maintaining transparency: a review of the developmental physiology and pathophysiology of two avascular tissuesQ36963548
Glutathione and its transporters in ocular surface defense.Q36972433
Oxidative responses induced by pharmacologic vitreolysis and/or long-term hyperoxia treatment in rat lensesQ37086683
Localization of multidrug resistance-associated protein 2 in the nonpigmented ciliary epithelium of the eye.Q37168510
Computational model for oxygen transport and consumption in human vitreousQ37232066
Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient miceQ37450243
Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.Q37454180
Focus on molecules: the cystine/glutamate exchanger (System x(c)(-)).Q37757386
The pathogenic role of Maillard reaction in the aging eye.Q37801857
The transsulfuration pathway: a source of cysteine for glutathione in astrocytesQ37849215
Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAP3-18.Q37849619
Vitreoretinal influences on lens function and cataractQ37852900
Glutathione and its function in the lens--an overviewQ37942373
Glutathione transportersQ38064620
Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1).Q38086728
Preserve the (intraocular) environment: the importance of maintaining normal oxygen gradients in the eye.Q38200972
Vitreous humor in the pathologic scope: insights from proteomic approaches.Q38293676
Ageing of the vitreous: From acute onset floaters and flashes to retinal detachmentQ38405460
Quantitative proteomics analysis by iTRAQ in human nuclear cataracts of different ages and normal lens nucleiQ39094909
Rhesus monkey aqueous humor composition and a primate ocular perfusateQ39699631
Transport of organic molecules in the lensQ39927823
Dynamics of transport systems in the eye. Friedenwald LectureQ40252966
GSH transporters: molecular characterization and role in GSH homeostasisQ40940194
Age-related cysteine uptake as rate-limiting in glutathione synthesis and glutathione half-life in the cultured human lensQ41165763
Human protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediatesQ42105203
Myopia and axial length contribute to vitreous liquefaction and nuclear cataractQ42783197
Age-dependent denaturation of enzymes in the human lens: a paradigm for organismic aging?Q43002298
Dynamic regulation of GSH synthesis and uptake pathways in the rat lens epitheliumQ43234997
Comment on: the Stokes-Einstein equation and the physiological effects of vitreous surgeryQ43241200
Is it possible to maintain a normal glutathione level in lenses in vitro?Q43507039
Mechanisms of ascorbic acid recycling in human erythrocytesQ43785334
Movement of cysteine in intact monkey lenses: the major site of entry is the germinative regionQ44520503
Molecular identification and cellular localization of a potential transport system involved in cystine/cysteine uptake in human lensesQ44643048
Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitaseQ44872524
The disposition and bioavailability of 35S-GSH from 35S-GSSG in BSS PLUS in rabbit ocular tissuesQ44997161
The presence of a transsulfuration pathway in the lens: a new oxidative stress defense systemQ45218351
Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formationQ45284559
Bidirectional glutathione transport by cultured human retinal pigment epithelial cellsQ46071867
Free amino acids in senile cataractous lenses: possible osmotic etiologyQ46159808
Molecular characterization of a reduced glutathione transporter in the lensQ46178201
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.Q46179370
Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye.Q46279198
P921main subjectglutathioneQ116907
P304page(s)103-111
P577publication date2016-06-29
P1433published inExperimental Eye ResearchQ15754753
P1476titleLens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches
P478volume156

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cites work (P2860)
Q89804790Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats
Q41039997Evaluation of antioxidants and argpyrimidine in normal and cataractous lenses in north Indian population
Q99414005Ex-Vivo Trans-Corneal and Trans-Scleral Diffusion Studies with Ocular Formulations of Glutathione as an Antioxidant Treatment for Ocular Diseases
Q92663191Mouse models for microphthalmia, anophthalmia and cataracts
Q92350692Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies
Q33645158Photoperiodic regime influences onset of lens opacities in a non-human primate
Q91716686Reactive cysteine residues in the oxidative dimerization and Cu2+ induced aggregation of human γD-crystallin: Implications for age-related cataract
Q41691753Retinitis Pigmentosa Associated with Glucose-6-Phosphate Dehydrogenase Deficiency
Q93005137Rosmarinic and Sinapic Acids May Increase the Content of Reduced Glutathione in the Lenses of Estrogen-Deficient Rats
Q47863726Signaling and Gene Regulatory Networks in Mammalian Lens Development
Q99616701Synchrotron-based FTIR microspectroscopy of protein aggregation and lipids peroxidation changes in human cataractous lens epithelial cells
Q59135654γ-Crystallin redox-detox in the lens

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