| scholarly article | Q13442814 |
| P50 | author | Laurent Perez | Q40036974 |
| Maurizio Fermeglia | Q41134526 | ||
| Sabrina Pricl | Q41134546 | ||
| Lara Brambilla | Q63762414 | ||
| Giuseppina M Carbone | Q90138640 | ||
| Carlo V Catapano | Q90138646 | ||
| Erik Laurini | Q90653270 | ||
| Davide Genini | Q117257448 | ||
| Jessica Merulla | Q117257449 | ||
| P2860 | cites work | Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells | Q24293124 |
| Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation | Q24632832 | ||
| Three-dimensional structure of the Stat3beta homodimer bound to DNA | Q27764842 | ||
| STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. | Q28253106 | ||
| Structure, function, and regulation of STAT proteins | Q28282800 | ||
| Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation | Q28288257 | ||
| Requirement of serine phosphorylation for formation of STAT-promoter complexes | Q28637366 | ||
| Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 | Q28637521 | ||
| STATs in cancer inflammation and immunity: a leading role for STAT3 | Q29547203 | ||
| AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility | Q29547658 | ||
| Stats: transcriptional control and biological impact | Q29547776 | ||
| Transcriptional and Non-Transcriptional Functions of PPARβ/δ in Non-Small Cell Lung Cancer | Q31103456 | ||
| Stattic: a small-molecule inhibitor of STAT3 activation and dimerization | Q33264035 | ||
| Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity | Q33282964 | ||
| The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors | Q33613105 | ||
| Therapeutic modulators of STAT signalling for human diseases | Q33684732 | ||
| A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells | Q33935165 | ||
| Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. | Q34272080 | ||
| Stat3 dimerization regulated by reversible acetylation of a single lysine residue | Q34384817 | ||
| Autocrine IL-6 signaling: a key event in tumorigenesis? | Q34732166 | ||
| Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors | Q34960206 | ||
| Toward a new STATe: the role of STATs in mitochondrial function | Q35064219 | ||
| Direct reprogramming of stem cell properties in colon cancer cells by CD44 | Q35176968 | ||
| The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors | Q35572396 | ||
| Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB | Q35812229 | ||
| Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA. | Q35922290 | ||
| Targeting the interleukin-6/Jak/stat pathway in human malignancies | Q35925127 | ||
| Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling | Q35963362 | ||
| Interleukin-6 regulation of prostate cancer cell growth | Q36101905 | ||
| JAK and STAT signaling molecules in immunoregulation and immune-mediated disease | Q36404704 | ||
| Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein | Q37015696 | ||
| Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells | Q37234973 | ||
| Paradigm shifts in the cell biology of STAT signaling | Q37240242 | ||
| Targeting signal transducer and activator of transcription signaling pathway in leukemias. | Q37347522 | ||
| Function of mitochondrial Stat3 in cellular respiration | Q37378567 | ||
| Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis | Q37486563 | ||
| Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. | Q38014908 | ||
| Revisiting STAT3 signalling in cancer: new and unexpected biological functions | Q38262473 | ||
| Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells | Q38360859 | ||
| Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells. | Q38971290 | ||
| JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells | Q39130848 | ||
| OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells | Q39195889 | ||
| Homology Model and Docking-Based Virtual Screening for Ligands of the σ1 Receptor. | Q39508226 | ||
| Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. | Q39675800 | ||
| Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase. | Q39678894 | ||
| Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells | Q39899676 | ||
| Live cell imaging of interleukin-6-induced targeting of "transcription factor" STAT3 to sequestering endosomes in the cytoplasm. | Q40099327 | ||
| Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity | Q40351340 | ||
| A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases | Q41850042 | ||
| Another brick in the wall. Validation of the σ1 receptor 3D model by computer-assisted design, synthesis, and activity of new σ1 ligands | Q45108635 | ||
| Stat3 activation in prostatic carcinomas. | Q53390466 | ||
| Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity | Q63884125 | ||
| The molecular basis of IGF-II/IGF2R recognition: a combined molecular dynamics simulation, free-energy calculation and computational alanine scanning study | Q84563006 | ||
| Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors | Q87857581 | ||
| P433 | issue | 6 | |
| P304 | page(s) | 1194-1206 | |
| P577 | publication date | 2015-03-05 | |
| P1433 | published in | Molecular Oncology | Q2190736 |
| P1476 | title | Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3) | |
| P478 | volume | 9 |
| Q52671159 | A First-in-Human Phase 1 Study of OPB-111077, a Small-Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers. |
| Q38591166 | A STAT inhibitor patent review: progress since 2011. |
| Q39275789 | Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015). |
| Q52655179 | Effects of purified Omphalia lapidescens protein on metastasis, cell cycle, apoptosis and the JAK-STAT signaling pathway in SGC-7901 human gastric cells. |
| Q93190592 | If You Cannot Win Them, Join Them: Understanding New Ways to Target STAT3 by Small Molecules |
| Q49273540 | Impact of STAT3 phosphorylation in glioblastoma stem cells radiosensitization and patient outcome |
| Q47150116 | Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells |
| Q41347601 | Molecular and functional characterization of a new 3' end KIT juxtamembrane deletion in a duodenal GIST treated with neoadjuvant Imatinib |
| Q36343400 | Multiple regulation pathways and pivotal biological functions of STAT3 in cancer. |
| Q38870465 | Novel STAT 3 inhibitors for treating gastric cancer |
| Q90697887 | Overview of the STAT-3 signaling pathway in cancer and the development of specific inhibitors |
| Q26798034 | Pattern Recognition Receptors in Cancer Progression and Metastasis |
| Q92814428 | Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers |
| Q92735027 | Protopanaxadiol inhibits epithelial-mesenchymal transition of hepatocellular carcinoma by targeting STAT3 pathway |
| Q90697892 | Role and mechanism of programmed death-ligand 1 in hypoxia-induced liver cancer immune escape |
| Q55637644 | Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development. |
| Q90533200 | Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis |
| Q90540850 | Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution |
| Q89157968 | Targeting Transcription Factors for Cancer Treatment |
| Q50191433 | Targeting the IL-6/JAK/STAT3 signalling axis in cancer |
| Q38687571 | The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations |
| Q64260465 | Transcriptional Reprogramming and Novel Therapeutic Approaches for Targeting Prostate Cancer Stem Cells |
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