Functional assessment of three Rem residues identified as critical for interactions with Ca(2+) channel β subunits.

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Functional assessment of three Rem residues identified as critical for interactions with Ca(2+) channel β subunits. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1022698154
P356DOI10.1007/S00424-015-1700-X
P698PubMed publication ID25771954

P50authorDilyana FilipovaQ59704564
P2093author name stringSymeon Papadopoulos
Roger A Bannister
Christin F Romberg
Donald Beqollari
P2860cites workDirect inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem.Q40477779
Presynaptic inhibition of elicited neurotransmitter releaseQ41462648
Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.Q43238362
Physiological patterns of electrical stimulation can induce neuronal gene expression by activating N-type calcium channels.Q43578176
Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heartQ44970367
Essential Ca(V)beta modulatory properties are AID-independentQ45306059
Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface densityQ81375760
Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activityQ24303682
Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heartQ24306819
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesQ24630460
The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiologyQ27863928
Direct inhibition of P/Q-type voltage-gated Ca 2+ channels by Gem does not require a direct Gem/Ca v β interactionQ30433191
Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split.Q31172439
Differential effects of RGK proteins on L-type channel function in adult mouse skeletal muscleQ33595731
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/GemQ33950353
Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heartQ34187371
Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channelsQ34271168
Exocytotic Ca2+ channels in mammalian central neuronsQ34293789
Bio-inspired voltage-dependent calcium channel blockersQ34308192
RGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubesQ34373988
The function of Ca(2+) channel subtypes in exocytotic secretion: new perspectives from synaptic and non-synaptic release.Q34498011
Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca2+ currentsQ35555097
Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channelsQ36080574
Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPasesQ36295882
Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channelsQ36494790
Rad GTPase deletion increases L-type calcium channel current leading to increased cardiac contractionQ37457760
Engineering proteins for custom inhibition of Ca(V) channelsQ37578943
Regulation of voltage-dependent calcium channels by RGK proteinsQ38051949
Neuronal voltage-gated calcium channels: structure, function, and dysfunctionQ38201848
Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failureQ39105764
Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPaseQ39724660
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmissionQ39757650
Molecular determinants of Rem2 regulation of N-type calcium channels.Q40012594
Genetically encoded molecules for inducibly inactivating CaV channels.Q40064199
RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain.Q40170542
Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPaseQ40264430
L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of currentQ40285739
Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation.Q40349479
P433issue11
P304page(s)2299-2306
P577publication date2015-03-15
P1433published inPfluegers ArchivQ1091689
P1476titleFunctional assessment of three Rem residues identified as critical for interactions with Ca(2+) channel β subunits
P478volume467

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cites work (P2860)
Q90250435A mutation in CaV2.1 linked to a severe neurodevelopmental disorder impairs channel gating
Q50078145A skeletal muscle L-type Ca2+ channel with a mutation in the selectivity filter (CaV1.1 E1014K) conducts K.
Q58612164Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels
Q35795789Rem uncouples excitation-contraction coupling in adult skeletal muscle fibers.

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