Chemistry of withaferin-A: chemo, regio, and stereoselective synthesis of novel spiro-pyrrolizidino-oxindole adducts of withaferin-A via one-pot three-component [3+2] azomethine ylide cycloaddition and their cytotoxicity evaluation

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Chemistry of withaferin-A: chemo, regio, and stereoselective synthesis of novel spiro-pyrrolizidino-oxindole adducts of withaferin-A via one-pot three-component [3+2] azomethine ylide cycloaddition and their cytotoxicity evaluation is …
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scholarly articleQ13442814

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P356DOI10.1007/S11030-015-9574-6
P698PubMed publication ID25749788
P5875ResearchGate publication ID273324370

P50authorYogesh P BharitkarQ57326808
Abhijit HazraQ57338642
P2093author name stringNirup B Mondal
Satish Kanhar
Susanta Kumar Mondal
Neradibilli Suneel
P2860cites workWithaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivoQ28482366
Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potentialQ33931189
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesisQ34091296
Total synthesis of (-)-spirotryprostatin B.Q34176006
Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cellsQ34209940
Withaferin A-stimulated Ca2+ entry, ceramide formation and suicidal death of erythrocytesQ34300468
Withaferin A is a potent inhibitor of angiogenesisQ34363498
Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.Q34588342
Development of withaferin A analogs as probes of angiogenesisQ35568686
Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic boneQ37148287
Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulinQ37488585
Epoxide group relationship with cytotoxicity in withanolide derivatives from Withania somniferaQ39067663
Formulation and development of a self-nanoemulsifying drug delivery system of irbesartanQ39151241
Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2.Q39516815
Selective cytotoxicity of goniothalamin against hepatoblastoma HepG2 cells.Q39562856
Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylationQ39918598
Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cellsQ40191168
Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues.Q41827821
Radiosensitizing effect of withaferin A combined with hyperthermia on mouse fibrosarcoma and melanomaQ42165431
Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cellsQ42746228
Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment.Q44959304
Microbial transformations of natural antitumor agents. 7. 14-alpha-Hydroxylation of withaferin-A by Cunninghamella elegans (NRRL 1393)Q45010309
Selective reactivity of 2-mercaptoethanol with 5beta,6beta-epoxide in steroids from Withania somniferaQ46864806
Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammationQ47691406
Horsfiline, an oxindole alkaloid from Horsfieldia superbaQ56619863
Unusually sulfated and oxygenated steroids from Withania somnifera.Q59649552
Microbial transformations of natural antitumor agents. 23. Conversion of withaferin-A to 12 beta- and 15 beta-hydroxy derivatives of withaferin-AQ70554967
A new route to spirooxindolesQ74320086
The tunable functionality of alpha,beta-unsaturated carbonyl compounds enables their differential application in biological systemsQ82692709
P433issue2
P921main subjectcytotoxicityQ246181
cycloadditionQ898648
stereoselectivityQ903429
P304page(s)251-261
P577publication date2015-03-08
P1433published inMolecular DiversityQ3319469
P1476titleChemistry of withaferin-A: chemo, regio, and stereoselective synthesis of novel spiro-pyrrolizidino-oxindole adducts of withaferin-A via one-pot three-component [3+2] azomethine ylide cycloaddition and their cytotoxicity evaluation
P478volume19

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cites work (P2860)
Q51008016A synthesis of functionalized dihydro-1Η-pyrrolizines and spiropyrrolizines via [2 + 3] cycloaddition reactions.
Q51046641A synthesis of fused acenaphthopyrrolizines via the 1,3-dipolar cycloaddition reaction of azomethine ylides with acetylenic esters.
Q41953145An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy.
Q38595326Molecular diversity of spirooxindoles. Synthesis and biological activity.
Q57794595Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells

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