Drug Disposition Classification Systems in Discovery and Development: A Comparative Review of the BDDCS, ECCS and ECCCS Concepts

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Drug Disposition Classification Systems in Discovery and Development: A Comparative Review of the BDDCS, ECCS and ECCCS Concepts is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S11095-016-2001-6
P8608Fatcat IDrelease_23re4ndehfcffgodlqvx2fn4le
P698PubMed publication ID27439505

P2093author name stringGian P Camenisch
P2860cites workClearance mechanism assignment and total clearance prediction in human based upon in silico modelsQ43848558
Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weightQ47278853
Shapes of membrane permeability-lipophilicity curves: extension of theoretical models with an aqueous pore pathway.Q52232875
SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatinQ57825149
Novel in vitro-in vivo extrapolation (IVIVE) method to predict hepatic organ clearance in ratQ82100906
Physicochemical determinants of human renal clearanceQ83838839
The BCS, BDDCS, and regulatory guidancesQ83857470
A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailabilityQ28293773
New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.Q31053819
Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactionsQ34190909
BDDCS applied to over 900 drugsQ34206152
Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification systemQ34403502
BDDCS class prediction for new molecular entitiesQ34634883
Quantitative structure-pharmacokinetic relationships for the prediction of renal clearance in humansQ34785494
Clinical Pharmacokinetics of AtorvastatinQ35553211
The use of BDDCS in classifying the permeability of marketed drugsQ36634723
The role of transporters in the pharmacokinetics of orally administered drugsQ37537018
Physiologically based pharmacokinetics (PBPK).Q37550553
Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorptionQ38056878
The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug developmentQ38059421
BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional DrugsQ38640797
BDDCS, the Rule of 5 and drugabilityQ38835159
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).Q38855314
In vitro-in vivo extrapolation method to predict human renal clearance of drugs.Q39022819
The role of permeability in drug ADME/PK, interactions and toxicity--presentation of a permeability-based classification system (PCS) for prediction of ADME/PK in humansQ39809409
Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statinsQ40916355
Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictionsQ41148725
Predicting when biliary excretion of parent drug is a major route of elimination in humansQ42846727
P433issue11
P304page(s)2583-2593
P577publication date2016-07-20
P1433published inPharmaceutical ResearchQ7180737
P1476titleDrug Disposition Classification Systems in Discovery and Development: A Comparative Review of the BDDCS, ECCS and ECCCS Concepts
P478volume33

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cites work (P2860)
Q63349796Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments
Q38849270Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations
Q49551182Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.
Q47163195Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats
Q53824747Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding.
Q56392055Rapid experimental measurements of physicochemical properties to inform models and testing
Q91368246Structural and functional pharmacokinetic analogs for physiologically based pharmacokinetic (PBPK) model evaluation
Q92730578Use of imaging to assess the activity of hepatic transporters

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