Entinostat, a novel histone deacetylase inhibitor is active in B-cell lymphoma and enhances the anti-tumour activity of rituximab and chemotherapy agents

scientific article

Entinostat, a novel histone deacetylase inhibitor is active in B-cell lymphoma and enhances the anti-tumour activity of rituximab and chemotherapy agents is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/BJH.13318
P932PMC publication ID5802357
P698PubMed publication ID25712263

P2093author name stringMyron S Czuczman
Qiang Hu
Francisco J Hernandez-Ilizaliturri
Cory Mavis
Juan J Gu
Matthew J Barth
Joseph Skitzki
Liu Song
Sarah Frys
Zachary Simons
P2860cites workTethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarizationQ37403050
Role of histone deacetylase inhibitors in the treatment of lymphomas and multiple myelomaQ38004217
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A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax(®)).Q39248784
Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell linesQ39973753
Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expressionQ40006309
Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin's B-lymphoma cells apoptosisQ40097403
Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levelsQ40117375
LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cellsQ40561963
Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapyQ40634072
Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas.Q41762088
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.Q42163084
HDAC inhibitors augment cytotoxic activity of rituximab by upregulating CD20 expression on lymphoma cellsQ42945834
CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphomaQ43864036
The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: a bio-CORAL studyQ44875676
CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphomaQ45115068
Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphomaQ46455509
Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alQ46669969
MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.Q52885667
Discovery of novel epigenetic markers in non-Hodgkin's lymphoma.Q54596898
Both Fc receptors and lymphocyte-function-associated antigen 1 on human T gamma lymphocytes are required for antibody-dependent cellular cytotoxicity (killer cell activity)Q71010222
Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa geneQ77535970
Neutrophils contribute to the biological antitumor activity of rituximab in a non-Hodgkin's lymphoma severe combined immunodeficiency mouse modelQ79367320
Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapyQ79835615
Maintenance therapy with rituximab leads to a significant prolongation of response duration after salvage therapy with a combination of rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) in patients with recurring and refractory follQ80199403
Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignanciesQ81310348
The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillanceQ27118298
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targetsQ28140238
Histone deacetylases and cancerQ28240447
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancerQ29615649
Anticancer activities of histone deacetylase inhibitorsQ29616624
p21 in cancer: intricate networks and multiple activitiesQ30436015
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphomaQ33386623
Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphomaQ33394023
Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies.Q33405714
Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell-mediated antibody-dependent cellular cytotoxicityQ34341016
Histone deacetylase inhibitors in Hodgkin lymphomaQ34414440
CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) GroupQ34566901
The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.Q34672100
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphomaQ34750551
Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivoQ35206717
The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors.Q35223868
HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCLQ35553330
Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumoursQ35653852
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemiasQ35750919
Regulation of CD20 in rituximab-resistant cell lines and B-cell non-Hodgkin lymphomaQ35783537
The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines.Q35953399
A phase 2 study of vorinostat for treatment of relapsed or refractory Hodgkin lymphoma: Southwest Oncology Group Study S0517.Q36337623
Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells.Q36403556
Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapyQ36703116
Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aQ36938662
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.Q37372837
P4510describes a project that useslimmaQ112236343
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectrituximabQ412323
entinostatQ1281020
B-cell lymphomaQ4833719
P304page(s)506-519
P577publication date2015-02-23
P1433published inBritish Journal of HaematologyQ4970200
P1476titleEntinostat, a novel histone deacetylase inhibitor is active in B-cell lymphoma and enhances the anti-tumour activity of rituximab and chemotherapy agents
P478volume169

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Q37144116Chidamide, a novel histone deacetylase inhibitor, inhibits the viability of MDS and AML cells by suppressing JAK2/STAT3 signaling
Q89403508Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells
Q89850073Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders
Q26744080Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies
Q92334161From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs
Q26781247Functional Role of G9a Histone Methyltransferase in Cancer
Q90254095HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma
Q38799515Histone Deacetylase Inhibitors Enhance the Therapeutic Potential of Reovirus in Multiple Myeloma
Q28082536Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy
Q90322835Mechanisms of Resistance to Monoclonal Antibodies (mAbs) in Lymphoid Malignancies
Q64260957Therapeutic targeting of immune checkpoints with small molecule inhibitors
Q39091822Treatment approaches of hard-to-treat non-Hodgkin lymphomas

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