Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system

scientific article

Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.3339-11.2011
P932PMC publication ID3206287
P698PubMed publication ID22016526

P2093author name stringStella E Tsirka
John K Robinson
Luisa Torres
Noreen Bukhari
P2860cites workThe chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injuryQ28191612
Regeneration of adult axons in white matter tracts of the central nervous systemQ28257832
NeuriteTracer: a novel ImageJ plugin for automated quantification of neurite outgrowthQ28364771
Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissueQ28566378
Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapseQ28572393
Chondroitinase ABC promotes functional recovery after spinal cord injuryQ29615017
Chondroitin-4-sulfation negatively regulates axonal guidance and growthQ30483928
Adult NG2+ cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injuryQ30493169
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
Structural characterization of the epitopes of the monoclonal antibodies 473HD, CS-56, and MO-225 specific for chondroitin sulfate D-type using the oligosaccharide library.Q33210460
Analysis of axonal regeneration in the central and peripheral nervous systems of the NG2-deficient mouseQ33300598
The plasminogen (fibrinolytic) systemQ33799992
In vivo imaging of axonal degeneration and regeneration in the injured spinal cordQ34410369
Chondroitin sulphate proteoglycans in the CNS injury responseQ35002812
Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological stateQ35012930
The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrateQ36326299
The primary structure of NG2, a novel membrane-spanning proteoglycanQ36530061
Chondroitinase ABC-mediated plasticity of spinal sensory functionQ37352467
tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2.Q37492517
Role of plasminogen activator in spinal cord remodeling after spinal cord injuryQ37570790
Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.Q38524950
Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycansQ40030617
Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuriesQ40525427
An inhibitor of neurite outgrowth produced by astrocytes.Q41464879
Inhibitory effects of brain chondroitin sulfate proteoglycans on neurite outgrowth from PC12D cellsQ41692170
Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.Q42140143
Amiloride selectively inhibits the urokinase-type plasminogen activatorQ42208028
Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II.Q43972707
Decreased neural damage after spinal cord injury in tPA-deficient miceQ44340136
Regulation of RPTPbeta/phosphacan expression and glycosaminoglycan epitopes in injured brain and cytokine-treated glia.Q44707559
Stem cells downregulate the elevated levels of tissue plasminogen activator in rats after spinal cord injuryQ46158053
NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors.Q46345563
Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycansQ48093854
Tissue plasminogen activator promotes axonal outgrowth on CNS myelin after conditioned injury.Q51818638
Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.Q52051559
Decorin promotes plasminogen/plasmin expression within acute spinal cord injuries and by adult microglia in vitro.Q54606892
Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytesQ67703308
An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampusQ71954963
Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycanQ72896530
Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injuryQ73458205
Chondroitinase ABC promotes axonal regeneration of Clarke's neurons after spinal cord injuryQ73735755
Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cordQ81411427
Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cordQ83282931
Plasminogen activator induction facilitates recovery of respiratory function following spinal cord injuryQ94608591
P4510describes a project that usesImageJQ1659584
P433issue42
P407language of work or nameEnglishQ1860
P921main subjectplasminogenQ107129060
P1104number of pages13
P304page(s)14931-14943
P577publication date2011-10-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleAxonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system
P478volume31

Reverse relations

cites work (P2860)
Q38770884ADAMTS-4 in central nervous system pathologies
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Q28571230Arylsulfatase B modulates neurite outgrowth via astrocyte chondroitin-4-sulfate: dysregulation by ethanol
Q37718952Astrocytic and vascular remodeling in the injured adult rat spinal cord after chondroitinase ABC treatment
Q33738641Chondroitin sulfate proteoglycans: structure-function relationship with implication in neural development and brain disorders
Q40419695Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axons from sites of spinal injury
Q38234093Designing drugs that encourage spinal cord injury healing
Q38795175Dynamic microglial modulation of spatial learning and social behavior
Q45168459Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury
Q34414830Examination of the combined effects of chondroitinase ABC, growth factors and locomotor training following compressive spinal cord injury on neuroanatomical plasticity and kinematics
Q34566967Extracellular matrix-associated gene expression in adult sensory neuron populations cultured on a laminin substrate.
Q30542858Intraventricular hemorrhage induces deposition of proteoglycans in premature rabbits, but their in vivo degradation with chondroitinase does not restore myelination, ventricle size and neurological recovery
Q33898347Kallikrein cascades in traumatic spinal cord injury: in vitro evidence for roles in axonopathy and neuron degeneration
Q37333802LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
Q37744900Lack of collagen XV is protective after ischemic stroke in mice.
Q37229269Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment
Q41831282Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury
Q38246350Molecular mechanisms of scar-sourced axon growth inhibitors
Q36955808Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury.
Q39007151Nicotinic regulation of experience-dependent plasticity in visual cortex.
Q26777276Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system
Q89371335Pifithrin-μ modulates microglial activation and promotes histological recovery following spinal cord injury
Q48392806Plasminogen activator inhibitor-1 promotes synaptogenesis and protects against aβ(1-42)-induced neurotoxicity in primary cultured hippocampal neurons
Q89049343Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain
Q93162167Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke
Q38222632Scar-modulating treatments for central nervous system injury
Q91130333Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice
Q28542725Subacute intranasal administration of tissue plasminogen activator promotes neuroplasticity and improves functional recovery following traumatic brain injury in rats
Q48614461The Role of TLR4 and Fyn Interaction on Lipopolysaccharide-Stimulated PAI-1 Expression in Astrocytes
Q40532626Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons
Q37042958Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice
Q30667273Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons
Q30836172Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors.
Q31057328Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis
Q36064401Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1
Q48140296Urokinase-type plasminogen activator modulates mammalian circadian clock phase regulation in tissue-type plasminogen activator knockout mice
Q28581097Valproic acid induces astrocyte-dependent neurite outgrowth from cultured rat primary cortical neuron via modulation of tPA/PAI-1 activity
Q45902163tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.

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