Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration.

scientific article

Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.DEVCEL.2016.06.031
P932PMC publication ID4982870
P698PubMed publication ID27459068

P50authorLaurel E HindQ86922312
Anna HuttenlocherQ89130659
P2093author name stringWilliam J B Vincent
P2860cites workHem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxisQ24301351
Cell movement is guided by the rigidity of the substrateQ24537364
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitmentQ24604033
Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositidesQ24645681
Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2Q24676628
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail associationQ24678197
Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarizationQ24683747
Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organsQ27324986
Neutrophil trails guide influenza-specific CD8⁺ T cells in the airwaysQ27331481
Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil MigrationQ27342448
Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblastsQ28189042
A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targetingQ28215157
Rac activation and inactivation control plasticity of tumor cell movementQ28299776
Macrophage motility is driven by frontal-towing with a force magnitude dependent on substrate stiffnessQ28821772
Tumour-cell invasion and migration: diversity and escape mechanismsQ29547894
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysisQ29616712
Plasticity of cell migration: a multiscale tuning modelQ29620332
Rapid leukocyte migration by integrin-independent flowing and squeezingQ29620345
Signaling networks that regulate cell migrationQ30278918
Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migrationQ30433120
Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxisQ30442416
Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxisQ30443781
Neutrophil microtubules suppress polarity and enhance directional migrationQ30475829
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxisQ30479639
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the frontQ30480454
The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migrationQ30482877
Neutrophil morphology and migration are affected by substrate elasticityQ30489549
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashionQ30499352
The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signalingQ30521733
Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.Q30522340
Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubulesQ30527782
Ezrin/Radixin/Moesin proteins and flotillins cooperate to promote uropod formation in T cellsQ30538458
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivoQ30561804
Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channelsQ30572256
Both contractile axial and lateral traction force dynamics drive amoeboid cell motilityQ30576931
Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration.Q30605978
Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradientQ30620016
Homer3 regulates the establishment of neutrophil polarityQ30651005
Cellular memory: neutrophil orientation reverses during temporally decreasing chemoattractant concentrationsQ32066425
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarityQ33660588
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafishQ33669166
Neutrophil adhesion and chemotaxis depend on substrate mechanicsQ33841582
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.Q33889530
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.Q34111723
Spatial and temporal analysis of Rac activation during live neutrophil chemotaxisQ34164011
The dynamics and mechanics of endothelial cell spreadingQ34350613
Microtubule asymmetry during neutrophil polarization and migration.Q34417618
Hax1 regulates neutrophil adhesion and motility through RhoA.Q34918167
Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxisQ35036887
Matrix confinement plays a pivotal role in regulating neutrophil-generated tractions, speed, and integrin utilizationQ35055624
The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gelsQ35058775
Traction forces of neutrophils migrating on compliant substratesQ35132807
Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytesQ35775396
Neutrophil traction stresses are concentrated in the uropod during migrationQ35781257
ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytesQ36273779
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cellsQ36274519
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxisQ36322960
Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3DQ36370710
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migrationQ36446872
Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cellsQ36563420
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movementQ36639138
Big roles for small GTPases in the control of directed cell movementQ36686091
Interstitial leukocyte migration in vivo.Q37196575
SHARPIN regulates uropod detachment in migrating lymphocytesQ37366883
Mechanical modes of 'amoeboid' cell migration.Q37518200
Locally excitable Cdc42 signals steer cells during chemotaxis.Q38810077
Actin flows mediate a universal coupling between cell speed and cell persistenceQ38896288
Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cellsQ38909995
Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migrationQ39408781
JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recyclingQ39899526
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.Q40284689
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migrationQ40900789
Clustering of a lipid-raft associated pool of ERM proteins at the immunological synapse upon T cell receptor or CD28 ligationQ44030188
Spatiotemporal regulation of moesin phosphorylation and rear release by Rho and serine/threonine phosphatase during neutrophil migration.Q44070516
Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathwaysQ44305045
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophilsQ44530451
Two poles and a compass.Q46019606
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophilsQ46544307
Chemotactically-induced redistribution of CD43 as related to polarity and locomotion of human polymorphonuclear leucocytesQ47663400
Vinculin arrests motile B cells by stabilizing integrin clustering at the immune synapse.Q47971383
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish.Q50715893
Forming the cell rear first: breaking cell symmetry to trigger directed cell migration.Q51905172
Bringing up the rear: defining the roles of the uropodQ57114622
Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like StructuresQ57911543
Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cellsQ58064394
Analysis of individual leucocyte behavior during chemotaxisQ69155871
Chemotactic reorientation of granulocytes stimulated with micropipettes containing fMet-Leu-PheQ70219622
LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachmentQ73508884
Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migrationQ73514637
Myosin II contributes to the posterior contraction and the anterior extension during the retraction phase in migrating Dictyostelium cellsQ78587393
Traction force microscopy in Dictyostelium reveals distinct roles for myosin II motor and actin-crosslinking activity in polarized cell movementQ80201753
Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblastsQ95721045
P433issue2
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)161-169
P577publication date2016-07-01
P1433published inDevelopmental CellQ1524277
P1476titleLeading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration
P478volume38

Reverse relations

cites work (P2860)
Q91291904Adaptive prospective optical gating enables day-long 3D time-lapse imaging of the beating embryonic zebrafish heart
Q99603730Conserved actin machinery drives microtubule-independent motility and phagocytosis in Naegleria
Q90499971Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin
Q90245337Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization
Q33785627Eosinophil Activation Status in Separate Compartments and Association with Asthma
Q64065247Inside-Out Control of Fc-Receptors
Q92728046Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment
Q48253793Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues.
Q52650595Mammalian nonmuscle myosin II comes in three flavors.
Q83227461Mechanisms of virus dissemination in bone marrow of HIV-1-infected humanized BLT mice
Q93049199Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer's Disease
Q59798178Nuclear Deformation During Neutrophil Migration at Sites of Inflammation
Q90295861Rotation of stress fibers as a single wheel in migrating fish keratocytes
Q90681115Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration
Q92562427Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization
Q90975492Substrate composition directs slime molds behavior
Q92924541Symmetry breaking and inter-clonal behavioural variability in a slime mould
Q60046863The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function
Q57676565The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury
Q88538598The function of TRP channels in neutrophil granulocytes
Q57464770Unique pattern of neutrophil migration and function during tumor progression
Q57818269Update on Neutrophil Function in Severe Inflammation

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