The anti-obesity drug orlistat reveals anti-viral activity

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The anti-obesity drug orlistat reveals anti-viral activity is …
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P6179Dimensions Publication ID1029325651
P356DOI10.1007/S00430-015-0391-4
P698PubMed publication ID25680890

P50authorAndreas HenkeQ88489003
P2093author name stringAndreas Sauerbrei
Sandor Nietzsche
Regine Heller
Alexander Kühnl
Christian Rien
Elisabeth Ammer
Theresa Mader
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Orlistat: its current status as an anti-obesity drugQ34635452
Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organellesQ34769274
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Host and virus determinants of picornavirus pathogenesis and tropismQ36277182
Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cellsQ36312437
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Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expressionQ37093515
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Fatty acid synthase is a potential therapeutic target in estrogen receptor-/progesterone receptor-positive endometrioid endometrial cancerQ38073079
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De novo lipogenesis in health and disease.Q38210722
Rewiring of cellular membrane homeostasis by picornavirusesQ38219637
Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replicationQ39163655
Characterization of coxsackievirus B3 replication in human umbilical vein endothelial cellsQ39234552
Identification of gene expression profiles in HeLa cells and HepG2 cells infected with Coxsackievirus B3.Q39273753
Induction of a broad spectrum of inflammation-related genes by Coxsackievirus B3 requires Interleukin-1 signalingQ39337854
Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release.Q39448952
Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animalQ39514357
Using recombinant coxsackievirus B3 to evaluate the induction and protective efficacy of CD8+ T cells during picornavirus infectionQ39605695
HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.Q39971963
The human fatty acid synthase: a new therapeutic target for coxsackievirus B3-induced diseases?Q40100828
Characterization of coxsackievirus B3-caused apoptosis under in vitro conditionsQ40633649
Phospholipid biosynthesis and poliovirus genome replication, two coupled phenomenaQ41215320
Host acyl coenzyme A binding protein regulates replication complex assembly and activity of a positive-strand RNA virusQ42152753
Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivoQ42375433
Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal targetQ42627763
Orlistat is a novel inhibitor of fatty acid synthase with antitumor activityQ44802884
Subinhibitory cerulenin inhibits staphylococcal exoprotein production by blocking transcription rather than by blocking secretionQ46693707
Increased susceptibility of male BALB/c mice to coxsackievirus B3-induced myocarditis: role for CD1dQ47702997
Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latencyQ48223425
Significance of short chain fatty acid transport by members of the monocarboxylate transporter family (MCT).Q48414696
MyocarditisQ55953402
Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitorQ57373885
Loss of Control of HIV Viremia Associated with the Fat Malabsorption Drug OrlistatQ63408879
Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathyQ72523290
Mode of action of orlistatQ73514352
Genotyping of different varicella vaccine strainsQ80100713
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
P304page(s)635-645
P577publication date2015-02-14
P1433published inMedical Microbiology and ImmunologyQ15760239
P1476titleThe anti-obesity drug orlistat reveals anti-viral activity
P478volume204

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cites work (P2860)
Q57008195Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity
Q84957829Evaluation of the antiviral activity of orlistat (tetrahydrolipstatin) against dengue virus, Japanese encephalitis virus, Zika virus and chikungunya virus
Q52559996Influence of sphingosine-1-phosphate signaling on HCMV replication in human embryonal lung fibroblasts.
Q45326176MCPIP1 inhibits coxsackievirus B3 replication by targeting viral RNA and negatively regulates virus-induced inflammation
Q28073474Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction
Q91847237The role of sphingosine-1-phosphate signaling in HSV-1-infected human umbilical vein endothelial cells

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