Pharmacological Agents Targeting Myocardial Metabolism for the Management of Chronic Stable Angina : an Update.

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Pharmacological Agents Targeting Myocardial Metabolism for the Management of Chronic Stable Angina : an Update. is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S10557-016-6677-Y
P698PubMed publication ID27497930

P50authorDoralisa MorroneQ60687724
P2093author name stringMario Marzilli
Alda Huqi
Giacinta Guarini
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Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failureQ37038947
Late sodium current inhibition as a new cardioprotective approachQ37156945
Modulation of fatty acids oxidation in heart failure by selective pharmacological inhibition of 3-ketoacyl coenzyme-A thiolaseQ37239156
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The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.Q42912074
B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute CoronaQ43124911
Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog modelQ43156268
A study of the effects of ranolazine using automated quantitative analysis of serial myocardial perfusion imagesQ43243349
Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathyQ43741617
Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLandQ43811969
Increase of adenosine plasma levels after oral trimetazidine: a pharmacological preconditioning?Q43872257
Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathyQ43995359
Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failureQ44112800
Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humansQ44200139
Coronary artery disease observed in general hospitals: ETTIC study. Comparison between trimetazidine and mononitrate isosorbide for patients receiving betablockersQ44270634
Cardioprotective effect of trimetazidine in severe ischemic cardiomyopathyQ44365373
Cardioprotective effect of trimetazidine during thrombolytic therapy in patients with acute myocardial infarction.Q44379335
Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemiaQ44493094
Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer statusQ44600111
Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathyQ44642224
Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: results from an international multicentre retrospective cohort studyQ45002764
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).Q45038648
Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease.Q45083293
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Comparative efficacy of ranolazine versus atenolol for chronic angina pectorisQ45238077
Efficacy comparison of trimetazidine with therapeutic alternatives in stable angina pectoris: a network meta-analysisQ45829479
Interpreting observational studies of disordered mineral metabolism and mortality in patients on hemodialysis.Q45911874
Improved left and right ventricular functions with trimetazidine in patients with heart failure: a tissue Doppler study.Q45922498
The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction.Q46031511
The effect of trimetazidine on cardiac function in diabetic patients with idiopathic dilated cardiomyopathyQ46191213
Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitationQ46363288
A prospective study on trimetazidine effectiveness and tolerability in diabetic patients in association to the previous treatment of their coronary disease. DIETRIC studyQ46377464
Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failureQ46507889
The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injuryQ46555429
Effects of trimetazidine on myocardial perfusion and the contractile response of chronically dysfunctional myocardium in ischemic cardiomyopathy: a 24-month studyQ46572134
Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulationQ46624550
Ranolazine inhibits an oxidative stress-induced increase in myocyte sodium and calcium loading during simulated-demand ischemiaQ46656428
Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathyQ46713286
Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetesQ46715059
The risk of sudden cardiac death in patients with non-ST elevation acute coronary syndrome and prolonged QTc interval: effect of ranolazineQ46803184
Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatmentQ46814911
Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium.Q46819135
Trimetazidine protective effect against ischemia-induced susceptibility to ventricular fibrillation in pigsQ46834471
Metabolic efficiency with ranolazine for less ischemia in non-ST elevation acute coronary syndromes (MERLIN TIMI-36) studyQ46839232
Ranolazine-induced postrepolarization refractoriness suppresses induction of atrial flutter and fibrillation in anesthetized rabbitsQ47292092
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocksQ48233485
Heart failure in older adults: a conversation with Dr Michael Rich. Interview by Dr Ali AhmedQ48553866
Efficacy of trimetazidine on functional capacity in symptomatic patients with stable exertional angina--the VASCO-angina studyQ48569178
New insights into the beneficial electrophysiologic profile of ranolazine in heart failure: prevention of ventricular fibrillation with increased postrepolarization refractoriness and without drug-induced proarrhythmia.Q51291841
Effects of ranolazine on the exercise capacity of rats with chronic heart failure induced by myocardial infarction.Q51579827
Improvement in cardiac energetics by perhexiline in heart failure due to dilated cardiomyopathy.Q51661667
P433issue4
P921main subjectstable anginaQ3617336
P304page(s)379-391
P577publication date2016-08-01
P1433published inCardiovascular Drugs and TherapyQ2473050
P1476titlePharmacological Agents Targeting Myocardial Metabolism for the Management of Chronic Stable Angina : an Update
P478volume30

Reverse relations

cites work (P2860)
Q92811820EXPRESS: Right Heart in Pulmonary Hypertension: From Adaptation to Failure
Q39093828Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature

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