KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin

scientific article published on September 2015

KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCP.24904
P698PubMed publication ID25536014

P2093author name stringJwu-Lai Yeh
Ing-Jun Chen
Jong-Hau Hsu
Shu-Fen Liou
Hung-Hong Lin
Hsin-Chieh Chu
P2860cites workKMUP-1 suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss: roles of MAPKs, Akt, NF-κB and calcium/calcineurin/NFATc1 pathwaysQ21090734
Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activityQ24323077
Cyclic nucleotide phosphodiesterasesQ28203598
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoterQ28208212
Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesisQ28248087
A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscleQ28356969
The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2Q28573356
The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiationQ28586194
Osteoclast differentiation and activationQ29547556
Effect of phosphodiesterase inhibitor-4, rolipram, on new bone formations by recombinant human bone morphogenetic protein-2.Q31047756
KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathwaysQ33730630
KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K(+) channelsQ35044163
KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channelsQ35047472
Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathwaysQ35047564
Control of osteoblast function and regulation of bone massQ35128237
Protein kinase G and focal adhesion kinase converge on Src/Akt/β-catenin signaling module in osteoblast mechanotransductionQ36033313
Building strong bones: molecular regulation of the osteoblast lineageQ37970567
Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signalsQ39707526
KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways.Q39766779
BMP/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: potential therapeutic targets for glucocorticoid-induced osteoporosisQ39902702
Ghrelin stimulates proliferation of human osteoblastic TE85 cells via NO/cGMP signaling pathway.Q39924750
Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiationQ40097285
Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alphaQ40134766
Guanosine 3',5'-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblastsQ40162643
Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cellsQ40366142
A phosphodiesterase inhibitor, pentoxifylline, enhances the bone morphogenetic protein-4 (BMP-4)-dependent differentiation of osteoprogenitor cellsQ40704227
MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.Q40901916
Involvement of phosphodiesterase isozymes in osteoblastic differentiationQ43866538
Piperazine-designed alpha 1A/alpha 1D-adrenoceptor blocker KMUP-1 and doxazosin provide down-regulation of androgen receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts.Q46163749
Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/beta-catenin signaling pathway.Q47446830
Epithelial sodium channel enhanced osteogenesis via cGMP/PKGII/ENaC signaling in rat osteoblast.Q54380855
Sinusoidal electromagnetic field stimulates rat osteoblast differentiation and maturation via activation of NO-cGMP-PKG pathway.Q54582938
Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene ExpressionQ57129723
P433issue9
P921main subjectosteoblastQ917177
P304page(s)2038-2048
P577publication date2015-09-01
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleKMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin
P478volume230

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cites work (P2860)
Q36327938Current Status of Research on Osteoporosis after Solid Organ Transplantation: Pathogenesis and Management
Q92215990ELP2 negatively regulates osteoblastic differentiation impaired by tumor necrosis factor α in MC3T3-E1 cells through STAT3 activation
Q40506281Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana).
Q93074563Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism
Q89293176The ERK/CREB pathway is involved in the c-Ski expression induced by low TGF-β1 concentrations during primary fibroblast proliferation

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