HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer

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HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PATH.4469
P698PubMed publication ID25345926
P5875ResearchGate publication ID267340764

P50authorManuela Pacyna-GengelbachQ83675743
P2093author name stringYuan Chen
Linlin Yang
Iver Petersen
Tiantian Cui
P2860cites workOncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiationQ24338350
The Hallmarks of CancerQ221226
Cancer statistics, 2012Q27860574
Atmospheric carbon dioxide concentrations over the past 60 million yearsQ28144787
Hop is an unusual homeobox gene that modulates cardiac developmentQ28203645
Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancerQ28205593
One hundred years of lung cancerQ28257141
Modulation of cardiac growth and development by HOP, an unusual homeodomain proteinQ28507581
Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expressionQ28589392
NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif☆☆Sequence data from this article have been deposited with the DDBJ/EMBL/GenBank Data Libraries under Accession No. AB059410Q30054218
Identification of differentially expressed genes in immortalized human bronchial epithelial cell line as a model for in vitro study of lung carcinogenesisQ30758961
Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factorQ33403307
Interconversion between intestinal stem cell populations in distinct nichesQ34231718
Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesisQ34408593
DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancerQ34727199
Senescence of human fibroblasts induced by oncogenic Raf.Q35210205
Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy.Q35693839
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.Q35886886
Intrinsic tumour suppressionQ35953133
The signals and pathways activating cellular senescenceQ36060167
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cellsQ36752936
Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasisQ36971430
Downregulation of HOPX controls metastatic behavior in sarcoma cells and identifies genes associated with metastasis.Q39111251
Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/β-catenin signaling pathway in human lung cancer.Q39315240
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescenceQ39674577
E7 abolishes raf-induced arrest via mislocalization of p21(Cip1).Q39695591
Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancerQ39727817
HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinomaQ40018700
Homeobox gene HOP has a potential tumor suppressive activity in human lung cancerQ40148089
Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) has potential tumour-suppressive activity in human lung cancer.Q40181385
The ability of E1A to rescue ras-induced premature senescence and confer transformation relies on inactivation of both p300/CBP and Rb family proteinsQ46571151
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
P304page(s)397-407
P577publication date2014-12-18
P1433published inJournal of PathologyQ400296
P1476titleHOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer
P478volume235