Overcoming 5-Fu resistance in human non-small cell lung cancer cells by the combination of 5-Fu and cisplatin through the inhibition of glucose metabolism

scientific article published on 27 September 2014

Overcoming 5-Fu resistance in human non-small cell lung cancer cells by the combination of 5-Fu and cisplatin through the inhibition of glucose metabolism is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1039936042
P356DOI10.1007/S13277-014-2543-3
P2888exact matchhttps://scigraph.springernature.com/pub.10.1007/s13277-014-2543-3
P698PubMed publication ID25260882

P2093author name stringJun Tang
Jun-Gang Zhao
Kai-Ming Ren
P2860cites workTargeting cellular metabolism to improve cancer therapeuticsQ24596727
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancerQ24652941
5-Fluorouracil: mechanisms of action and clinical strategiesQ28201937
A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumorsQ28281237
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damageQ28481378
Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cellsQ33212894
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic targetQ34310486
Molecular mechanisms of drug resistanceQ34382998
Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancerQ34595323
Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a reviewQ34788267
Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.Q35085558
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolismQ37002755
5-Fluorouracil: mechanisms of resistance and reversal strategiesQ37270356
Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects.Q37653797
Molecular mechanisms of cisplatin resistanceQ37926477
Early reduction of glucose uptake after cisplatin treatment is a marker of cisplatin sensitivity in ovarian cancerQ39672706
Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in miceQ39699461
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivoQ39835139
Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxiaQ40244028
Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines.Q40582817
Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 statusQ43938032
Acquired resistance of pancreatic cancer cells towards 5-Fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genesQ44077436
2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivoQ44732835
Screening for dihydropyrimidine dehydrogenase deficiencyQ46610591
Synergistic activity of oxaliplatin and 5-fluorouracil in patients with metastatic colorectal cancer with progressive disease while on or after 5-fluorouracilQ74648273
P433issue12
P921main subjectcisplatinQ412415
P304page(s)12305-12315
P577publication date2014-09-27
P1433published inTumor BiologyQ15757842
P1476titleOvercoming 5-Fu resistance in human non-small cell lung cancer cells by the combination of 5-Fu and cisplatin through the inhibition of glucose metabolism
P478volume35

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cites work (P2860)
Q594624825-Fluorouracil Loaded Chitosan-PVA/NaMMT Nanocomposite Films for Drug Release and Antimicrobial Activity
Q36958403Cisplatin suppresses the growth and proliferation of breast and cervical cancer cell lines by inhibiting integrin β5-mediated glycolysis
Q92441132Scaffold-based lung tumor culture on porous PLGA microparticle substrates
Q38903756Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells
Q38762901Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer

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