Stimulation and suppression of innate immune function by American ginseng polysaccharides: biological relevance and identification of bioactives

scientific article published on 11 September 2014

Stimulation and suppression of innate immune function by American ginseng polysaccharides: biological relevance and identification of bioactives is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11095-014-1503-3
P698PubMed publication ID25208875
P5875ResearchGate publication ID265558326

P2093author name stringPaul A Charpentier
Edmund M K Lui
Chike G Azike
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Red ginseng acidic polysaccharide (RGAP) in combination with IFN-gamma results in enhanced macrophage function through activation of the NF-kappaB pathwayQ38500029
Antidepressant-like effects of the active acidic polysaccharide portion of ginseng in mice.Q39284050
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Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lungQ40109343
Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan.Q40314831
Levan (beta-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulQ40333969
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Safflower polysaccharides activate the transcription factor NF-kappa B via Toll-like receptor 4 and induce cytokine production by macrophagesQ40701269
Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan.Q40709684
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Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginsengQ41059501
Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats.Q41808289
The Yin and Yang actions of North American ginseng root in modulating the immune function of macrophagesQ42098625
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Antitumor activities and immunomodulatory effects of ginseng neutral polysaccharides in combination with 5-fluorouracilQ43173663
Effect of simvastatin on proinflammatory cytokines production during lipopolysaccharide-induced inflammation in rats.Q43247623
Extractable polysaccharides of Panax quinquefolius L. (North American ginseng) root stimulate TNFalpha production by alveolar macrophagesQ44131856
Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsisQ44173204
Anti-hyperglycemic effect of the polysaccharides fraction from American ginseng berry extract in ob/ob miceQ44834433
Prophylaxis of lipopolysaccharide-induced shock by alpha-galactosylceramideQ45068192
Effect of CVT-E002 (COLD-fX) versus a ginsenoside extract on systemic and gut-associated immune functionQ46543418
High molecular weight polysaccharides are key immunomodulators in North American ginseng extracts: characterization of the ginseng genetic signature in primary human immune cellsQ47314490
Calf intestinal alkaline phosphatase, a novel therapeutic drug for lipopolysaccharide (LPS)-mediated diseases, attenuates LPS toxicity in mice and pigletsQ47630343
A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A.Q48011109
Kinetics of endotoxin and tumor necrosis factor appearance in portal and systemic circulation after hemorrhagic shock in ratsQ50115798
Preventive effect of Hochu-ekki-to on lipopolysaccharide-induced acute lung injury in BALB/c mice.Q51777791
Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages.Q53617453
The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals.Q54627218
Molecular mechanisms of endotoxin activityQ58003744
Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivoQ58862657
The sustained influence of short term exposure to a proprietary extract of North American ginseng on the hemopoietic cells of the bone marrow, spleen and blood of adult and juvenile mice.Q64945565
Characterization of two novel polysaccharides having immunological activities from the root of Panax ginsengQ72784348
Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium)Q77320300
Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophagesQ78148082
Immunomodulating activities of polysaccharides isolated from Panax ginsengQ80024810
Immunoactive polysaccharide-rich fractions from Panax notoginsengQ80278566
Polycationic lipids inhibit the pro-inflammatory response to LPSQ81110055
Extract of North American ginseng (Panax quinquefolius), administered to leukemic, juvenile mice extends their life spanQ84511589
CVT-E002 stimulates the immune system and extends the life span of mice bearing a tumor of viral originQ84832342
P433issue3
P921main subjectginsengQ20817212
polysaccharideQ134219
immune functionQ124683452
P304page(s)876-897
P577publication date2014-09-11
P1433published inPharmaceutical ResearchQ7180737
P1476titleStimulation and suppression of innate immune function by American ginseng polysaccharides: biological relevance and identification of bioactives
P478volume32

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cites work (P2860)
Q49321512Ginseng: An Nonnegligible Natural Remedy for Healthy Aging
Q40626549North American ginseng influences adipocyte-macrophage crosstalk regulation of inflammatory gene expression
Q33661052The protective role of nitric oxide-dependent innate immunosuppression in the early stage of cartilage damage in rats: Role of nitric oxide in cartilage damage

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