Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation

scientific article published on 29 November 2016

Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2016.11.072
P932PMC publication ID5192010
P698PubMed publication ID27912985

P50authorNirbhay KumarQ56789145
P2093author name stringDrew Hannaman
Dietlind L Gerloff
Barry Ellefsen
Dibyadyuti Datta
Geetha P Bansal
P2860cites workElectroporation-based DNA transfer enhances gene expression and immune responses to DNA vaccines in cattleQ81792807
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Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41Q27230051
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A central role for P48/45 in malaria parasite male gamete fertilityQ30043154
Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparumQ30043157
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Evaluation of the Impact of Codon Optimization and N-Linked Glycosylation on Functional Immunogenicity of Pfs25 DNA Vaccines Delivered by In Vivo Electroporation in Preclinical Studies in MiceQ35998776
Plasmodium falciparum Gametocyte-Specific Antibody Profiling Reveals Boosting through Natural Infection and Identifies Potential Markers of Gametocyte ExposureQ36138015
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Markedly enhanced immunogenicity of a Pfs25 DNA-based malaria transmission-blocking vaccine by in vivo electroporationQ36428352
Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in miceQ36670217
Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboonsQ36941152
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Reduced immunogenicity of Plasmodium falciparum gamete surface antigen (Pfs48/45) in mice after disruption of disulphide bonds - evaluating effect of interferon-γ-inducible lysosomal thiol reductase.Q39246146
Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunizationQ39504399
A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporationQ40665953
Plasmodium falciparum: heterologous synthesis of the transmission-blocking vaccine candidate Pfs48/45 in recombinant vaccinia virus-infected cellsQ41003251
Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondiiQ41910735
Monoclonal antibodies against surface determinants on gametes of Plasmodium gallinaceum block transmission of malaria parasites to mosquitoesQ43032460
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Plasmodium falciparum transmission blocking monoclonal antibodies recognize monovalently expressed epitopesQ44146493
Potent immunogenicity of DNA vaccines encoding Plasmodium vivax transmission-blocking vaccine candidates Pvs25 and Pvs28-evaluation of homologous and heterologous antigen-delivery prime-boost strategyQ44161423
Biosynthesis of the target antigens of antibodies blocking transmission of Plasmodium falciparumQ44165535
Enhancement of immune responses to an HBV DNA vaccine by electroporationQ44643829
Epitope analysis of the malaria surface antigen pfs48/45 identifies a subdomain that elicits transmission blocking antibodies.Q47829675
Immunological properties of recombinant proteins of the transmission blocking vaccine candidate, Pfs48/45, of the human malaria parasite Plasmodium falciparum produced in Escherichia coli.Q47837358
Assembly and expression of a synthetic gene encoding the antigen Pfs48/45 of the human malaria parasite Plasmodium falciparum in yeastQ47857505
Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbitsQ47883813
Predicted disulfide-bonded structures for three uniquely related proteins of Plasmodium falciparum, Pfs230, Pfs48/45 and Pf12.Q47998054
Production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expressing bacterial PNGase F.Q48007592
Characterization of Plasmodium falciparum sexual stage antigens and their biosynthesis in synchronised gametocyte culturesQ68897064
Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trialQ73234978
Plasmodium falciparum: production and characterization of rat monoclonal antibodies specific for the sexual-stage Pfs48/45 antigenQ73509627
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectelectroporationQ1142521
malaria vaccineQ6741353
malaria transmissionQ56928847
P304page(s)264-272
P577publication date2016-11-29
P1433published inVaccineQ7907941
P1476titleImmunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation
P478volume35

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cites work (P2860)
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Q58765365Functional Conservation of P48/45 Proteins in the Transmission Stages of (Human Malaria Parasite) and . (Murine Malaria Parasite)
Q92001627Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites
Q91941697Outer membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230
Q58608381Plasmodium genomics: an approach for learning about and ending human malaria