Toxic effects of TiO2 nanoparticles in primary cultured rat sertoli cells are mediated via a dysregulated Ca2+ /PKC/p38 MAPK/NF-κB cascade

scientific article published on 11 February 2017

Toxic effects of TiO2 nanoparticles in primary cultured rat sertoli cells are mediated via a dysregulated Ca2+ /PKC/p38 MAPK/NF-κB cascade is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JBM.A.36021
P698PubMed publication ID28188686

P2093author name stringFashui Hong
Yuguan Ze
Lingjuan Li
Xiao Ze
Yaoming Zhou
Lingqun Ye
P2860cites workImmunological, paracrine and endocrine aspects of testicular immune privilege.Q37723795
Toxicology of nanoparticlesQ37933878
Nanoparticles and spermatogenesis: how do nanoparticles affect spermatogenesis and penetrate the blood-testis barrierQ37999461
Compromised MAPK signaling in human diseases: an updateQ38359194
Lung inflammation caused by adenosine-5'-triphosphate is mediated via Ca2+/PKCs-dependent COX-2/PGE2 inductionQ39151028
The effects of nanoparticles on mouse testis Leydig cells in vitroQ39937658
17-beta-estradiol elicits genomic and non-genomic responses in mouse male germ cellsQ40403129
Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming.Q40466935
Mechanical pressure-induced phosphorylation of p38 mitogen-activated protein kinase in epithelial cells via Src and protein kinase C.Q40576522
Characterization of Ca2+-activated Cl– currents in mouse kidney inner medullary collecting duct cellsQ40651205
TiO2 Nanoparticle Exposure Decreases Spermatogenesis via Biochemical Dysfunctions in the Testis of Male MiceQ40767506
Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophagesQ40935358
Ovarian dysfunction and gene-expressed characteristics of female mice caused by long-term exposure to titanium dioxide nanoparticlesQ42714420
Long-term potentiation of wound-induced exocytosis and plasma membrane repair is dependent on cAMP-response element-mediated transcription via a protein kinase C- and p38 MAPK-dependent pathwayQ42826277
Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticlesQ42943532
Evaluating cytotoxicity and cellular uptake from the presence of variously processed TiO2 nanostructured morphologiesQ43090682
alpha1-Adrenergic receptor stimulates interleukin-6 expression and secretion through both mRNA stability and transcriptional regulation: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB.Q43106563
Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavityQ43270729
Titanium dioxide nanoparticle-induced testicular damage, spermatogenesis suppression, and gene expression alterations in male miceQ43494645
Titanium dioxide nanomaterials: synthesis, properties, modifications, and applicationsQ44481495
Endocrine disrupting alkylphenols: structural requirements for their adverse effects on Ca2+ pumps, Ca2+ homeostasis & Sertoli TM4 cell viability.Q46387418
Plasma membrane Ca2+-ATPase regulates Ca2+ signaling and the proliferation of airway smooth muscle cellsQ46735775
Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles.Q51008927
Chronic exposure to nanoparticulate TiO2 causes renal fibrosis involving activation of the Wnt pathway in mouse kidney.Q53640009
Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.Q54303241
Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticlesQ54400542
The p38 mitogen-activated protein kinases modulate endothelial cell survival and tissue repair.Q54545676
Cardiac inflammation involving in PKCε or ERK1/2-activated NF-κB signalling pathway in mice following exposure to titanium dioxide nanoparticles.Q55025732
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathwayQ24306909
Nanotechnology, nanotoxicology, and neuroscienceQ24650444
The transcription factor nuclear factor-kappa B and cancerQ28220764
Titanium dioxide in our everyday life; is it safe?Q28387726
Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic studyQ28393493
Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in XenopusQ28613481
Interaction Between Nano-Anatase TiO(2) and Liver DNA from Mice In VivoQ33948347
Inflammatory mediators increase surface expression of integrin ligands, adhesion to lymphocytes, and secretion of interleukin 6 in mouse Sertoli cells.Q34154676
Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testisQ34267661
Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female miceQ34657909
Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive developmentQ34882580
Nano-sized titanium dioxide-induced splenic toxicity: a biological pathway explored using microarray technologyQ35195729
TiO2 nanoparticles-induced apoptosis of primary cultured Sertoli cells of miceQ35735828
Decreased spermatogenesis led to alterations of testis-specific gene expression in male mice following nano-TiO2 exposureQ35752428
Titanium dioxide nanoparticles in food and personal care productsQ35784145
Exposure to TiO2 Nanoparticles Induces Immunological Dysfunction in Mouse TestitisQ35882746
Toxicological effect of TiO2 nanoparticle-induced myocarditis in miceQ35946850
Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells.Q36781382
Cytokines and chemokines in testicular inflammation: A brief reviewQ37407207
Blood-testis barrier, junctional and transport proteins and spermatogenesisQ37621356
P433issue5
P921main subjectNF-κBQ411114
TiO2 nanoparticleQ125311943
P304page(s)1374-1382
P577publication date2017-02-11
P1433published inJournal of Biomedical Materials Research Part AQ15749234
P1476titleToxic effects of TiO2 nanoparticles in primary cultured rat sertoli cells are mediated via a dysregulated Ca2+ /PKC/p38 MAPK/NF-κB cascade
P478volume105

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cites work (P2860)
Q61447778Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca-dependent PKC/p38MAPK/NF-κB pathway
Q38766068Exogenous CGRP upregulates profibrogenic growth factors through PKC/JNK signaling pathway in kidney proximal tubular cells.
Q60909725Memory effect of arsenic-induced cellular response and its influences on toxicity of titanium dioxide nanoparticle
Q66679112Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis
Q57490339Suppression of testosterone production by nanoparticulate TiO is associated with ERK1/2-PKA-PKC signaling pathways in rat primary cultured Leydig cells

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