Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis

scientific article

Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3762/BJOC.10.55
P932PMC publication ID3999764
P698PubMed publication ID24778714
P5875ResearchGate publication ID261957348

P50authorPeter LeadlayQ21165144
P2093author name stringFrank Hahn
Nadine Kandziora
Steffen Friedrich
P2860cites workKetoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitroQ28267705
Diastereoselective magnesium halide-catalyzed anti-aldol reactions of chiral N-acyloxazolidinonesQ33956850
Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domainQ34222389
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functionsQ34316866
Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment.Q38478388
In vitro reconstruction of tetronate RK-682 biosynthesisQ41957518
Stereospecificity of the dehydratase domain of the erythromycin polyketide synthaseQ42184169
Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthaseQ43646130
A model of structure and catalysis for ketoreductase domains in modular polyketide synthasesQ44270898
Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthasesQ44507378
Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cellsQ44620354
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formationQ44928499
Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase: Implications for cis Double Bond FormationQ60301795
Achieving High Selectivity and Facile Displacement with a New Thiol Auxiliary for Boron-Mediated Aldol ReactionsQ61188543
Enzymes and catalysts. I. Pig liver esterase-catalyzed hydrolysis of heterocyclic diestersQ69419615
[Metabolic products of microorganisms. Concerning the constitution of borrelidin]Q71863277
Coenzyme A Analogues and Derivatives: Synthesis and Applications as Mechanistic Probes of Coenzyme A Ester-Utilizing EnzymesQ77451062
In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of PlasmodiaQ79174887
Total synthesis of (-)-borrelidinQ80105994
Borrelidin, a new antibiotic with antiborrelia activity and penicillin enhancement propertiesQ80354027
P921main subjectborrelidinQ27147895
P304page(s)634-640
P577publication date2014-03-11
P1433published inBeilstein Journal of Organic ChemistryQ2894008
P1476titleSynthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis
P478volume10

Reverse relations

cites work (P2860)
Q47888353Stereospecific Formation of E- and Z-Disubstituted Double Bonds by Dehydratase Domains from Modules 1 and 2 of the Fostriecin Polyketide Synthase
Q92209523Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases
Q64988559Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi.
Q53581941Truncated borrelidin analogues: synthesis by sequential cross metathesis/olefination for the southern fragment and biological evaluation.

Search more.