Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors

scientific article

Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1083537770
P356DOI10.1007/S10637-016-0413-0
P932PMC publication ID5502198
P698PubMed publication ID28161886

P50authorMrinal GounderQ92508279
Shadia I. JalalQ91794500
P2093author name stringJennifer Hall
John Kauh
Patricia M LoRusso
E Gabriela Chiorean
Nick Loizos
Jan Cosaert
Aejaz Nasir
Timothy R Holzer
Valérie André
Siva Rama Prasad Kambhampati
P2860cites workCross-talk between the proto-oncogenes Met and RonQ22254408
The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasivenessQ28201215
Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potentialQ28203075
The Ron proto-oncogene product is a phenotypic marker of renal oncocytomaQ28206427
Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantaisQ28213995
Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivoQ28221233
Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinaseQ29307795
Tumour-educated macrophages promote tumour progression and metastasisQ29614307
The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapiesQ29614311
Smoldering and polarized inflammation in the initiation and promotion of malignant diseaseQ29618034
Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinaseQ33703886
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis.Q33916081
Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinaseQ35154868
RON, a tyrosine kinase receptor involved in tumor progression and metastasisQ36096934
Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladderQ36615866
Multiple variants of the RON receptor tyrosine kinase: biochemical properties, tumorigenic activities, and potential drug targetsQ36949153
Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancerQ39048792
Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients.Q40443024
Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell linesQ40841807
Overexpression of the RON gene in human breast carcinomaQ41023826
Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migrationQ41047718
Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptorQ42795830
Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasisQ42824776
Immunohistochemical analysis of distribution of RON receptor tyrosine kinase in human digestive organsQ43561410
Expression of RON Proto-oncogene in Renal Oncocytoma and Chromophobe Renal Cell CarcinomaQ44977133
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activationQ57100119
Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell linesQ73491986
P433issue4
P304page(s)442-450
P577publication date2017-02-04
P1433published inInvestigational New DrugsQ2312231
P1476titlePhase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors
P478volume35

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cites work (P2860)
Q95273187Targeting RON receptor tyrosine kinase for treatment of advanced solid cancers: antibody-drug conjugates as lead drug candidates for clinical trials
Q91673432Therapeutic Considerations for Ron Receptor Expression in Prostate Cancer
Q92648096Therapeutic anti-cancer activity of antibodies targeting sulfhydryl bond constrained epitopes on unglycosylated RON receptor tyrosine kinase
Q64093978Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy
Q59130211mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential