Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies

scientific article

Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/1352458517690617
P698PubMed publication ID28156185

P50authorRalf GoldQ99630149
P2093author name stringAlvydas Mikulskis
Robert J Fox
Katherine T Dawson
Lakshmi Amaravadi
Sreeja Gopal
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Ethanol-induced HO-1 and NQO1 Are Differentially Regulated by HIF-1α and Nrf2 to Attenuate Inflammatory Cytokine ExpressionQ28579518
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The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapyQ35688436
Pharmacokinetics of oral fumarates in healthy subjects.Q35826385
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Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS.Q35856171
Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosisQ36439880
Disease-modifying drugs for multiple sclerosis: current and future aspectsQ36613906
Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.Q36866185
Fumaric acid and its esters: an emerging treatment for multiple sclerosis with antioxidative mechanism of actionQ37854243
Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke.Q37885608
Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent MechanismsQ38449822
The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonistQ39947934
Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cellsQ40126530
P407language of work or nameEnglishQ1860
P921main subjectmultiple sclerosisQ8277
P304page(s)1352458517690617
P577publication date2017-01-01
P1433published inMultiple Sclerosis JournalQ1952449
P1476titleEvidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies

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