Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling

scientific article published on 9 May 2014

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBRC.2014.04.150
P932PMC publication ID4051991
P698PubMed publication ID24814708
P5875ResearchGate publication ID262231253

P50authorKarl-Heinz WagnerQ38362708
Leo E OtterbeinQ57032230
Barbara WegielQ77368594
P2093author name stringAndrew C Bulmer
Oliver Neubauer
Kavita Bisht
Jens Tampe
P2860cites workAccurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesQ24534395
NF-kappaB activation and inhibition: a reviewQ28217099
Upstream and downstream of mTORQ28277365
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New insights of an old defense system: structure, function, and clinical relevance of the complement systemQ34699496
Effects of biliverdin administration on acute lung injury induced by hemorrhagic shock and resuscitation in ratsQ34718303
Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductaseQ35558775
Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administrationQ35636116
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivoQ35850677
Functional role for toll-like receptors in atherosclerosis and arterial remodelingQ35884631
Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndromeQ36041536
Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt.Q37372039
Complement activation and disease: protective effects of hyperbilirubinaemiaQ37609484
Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settingsQ37779560
Go green: the anti-inflammatory effects of biliverdin reductaseQ37996018
Exploring the specificity of the PI3K family inhibitor LY294002.Q40170788
Effects of bilirubin on neutrophil responses in newborn infants.Q40289042
Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migrationQ40516272
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cellsQ40726959
Tumor necrosis factor-alpha mRNA remains unstable and hypoadenylated upon stimulation of macrophages by lipopolysaccharidesQ40853644
Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophagesQ42088673
C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinase-signaling pathwayQ43889524
Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.Q44641990
Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allograftsQ44772668
Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.Q46036068
The TSC-mTOR signaling pathway regulates the innate inflammatory responseQ46321173
Biliverdin administration protects against endotoxin-induced acute lung injury in ratsQ46697021
Complement takes its Toll: an inflammatory crosstalk between Toll-like receptors and the receptors for the complement anaphylatoxin C5a.Q48206428
In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrrolesQ50025304
Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice.Q54378056
Processing of tumour necrosis factor-α precursor by metalloproteinasesQ59059630
Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritinQ64375853
C5a receptor and thymocyte apoptosis in sepsisQ74211259
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendotoxinsQ319997
P304page(s)94-99
P577publication date2014-05-09
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleBiliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling
P478volume449

Reverse relations

cites work (P2860)
Q90625004Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health
Q28071435Bilirubin in coronary artery disease: Cytotoxic or protective?
Q39080342Biological signaling by carbon monoxide and carbon monoxide-releasing molecules
Q63916924Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway
Q34093709Endogenous Tetrapyrroles Influence Leukocyte Responses to Lipopolysaccharide in Human Blood: Pre-Clinical Evidence Demonstrating the Anti-Inflammatory Potential of Biliverdin.
Q92510535Heme Catabolic Pathway in Inflammation and Immune Disorders
Q61443683Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury
Q48578792Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells
Q89820673Heme-Derived Metabolic Signals Dictate Immune Responses
Q49588930Immune challenges decrease biliverdin concentration in the spleen of northern Bobwhite quail, Colinus virginianus
Q37693865Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking.
Q41774347Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation
Q91433898Modulation of the monocyte/macrophage system in heart failure by targeting heme oxygenase-1
Q91896679Protective Role of mTOR in Liver Ischemia/Reperfusion Injury: Involvement of Inflammation and Autophagy
Q27715540Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosis
Q99708873The Role of Bilirubin and the Other "Yellow Players" in Neurodegenerative Diseases

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