TP53 Mutations in Breast and Ovarian Cancer

scientific article published on 4 November 2016

TP53 Mutations in Breast and Ovarian Cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1101/CSHPERSPECT.A026252
P932PMC publication ID5204332
P698PubMed publication ID27815305

P50authorAnne-Lise Børresen-DaleQ11958220
Anita LangerødQ65594287
Laxmi Silwal-PanditQ41608095
P2860cites workMutant p53 disrupts mammary tissue architecture via the mevalonate pathwayQ24302433
International network of cancer genome projectsQ24611474
Mutation and cancer: statistical study of retinoblastomaQ24618185
Mutational processes molding the genomes of 21 breast cancersQ24620915
Comprehensive molecular portraits of human breast tumoursQ24630844
Massive genomic rearrangement acquired in a single catastrophic event during cancer developmentQ24631164
A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinomaQ71079779
Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patientsQ71169983
Identification of allelic losses in benign, borderline, and invasive epithelial ovarian tumors and correlation with clinical outcomeQ73748200
Mutant p53 gain of function is interwoven into the hallmarks of cancerQ82183156
Links between mutant p53 and genomic instabilityQ26864033
The changing view of high-grade serous ovarian cancerQ27025411
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancerQ27824864
p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.Q27851827
Integrated genomic analyses of ovarian carcinomaQ27860518
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsQ27860709
Molecular portraits of human breast tumoursQ28032461
Repeated observation of breast tumor subtypes in independent gene expression data setsQ28131820
p53 mutations in human cancersQ28302973
Signatures of mutational processes in human cancerQ29547191
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
The landscape of cancer genes and mutational processes in breast cancerQ29614637
The life history of 21 breast cancersQ29614642
Supervised risk predictor of breast cancer based on intrinsic subtypesQ29617404
p53: puzzle and paradigmQ29618407
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasmsQ29618586
Hallmarks of 'BRCAness' in sporadic cancersQ29618825
The clonal and mutational evolution spectrum of primary triple-negative breast cancersQ29619914
Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcomeQ33359495
TP53 mutations in human cancers: origins, consequences, and clinical useQ33685392
Mutant p53 gain-of-function in cancerQ33687048
Predictive and prognostic impact of TP53 mutations and MDM2 promoter genotype in primary breast cancer patients treated with epirubicin or paclitaxelQ33893910
Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovaryQ34103978
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of originQ34123261
The biological and clinical value of p53 expression in pelvic high-grade serous carcinomas.Q34125898
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutationsQ34248736
Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genesQ34292432
p53 Research: the past thirty years and the next thirty years.Q34313764
Prognostic and therapeutic relevance of molecular subtypes in high-grade serous ovarian cancerQ34736974
TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma.Q34775855
Clinical relevance of gain-of-function mutations of p53 in high-grade serous ovarian carcinomaQ34965421
Emerging landscape of oncogenic signatures across human cancersQ35058708
TP53 and ovarian cancerQ35078757
TP53 and breast cancerQ35078761
Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entityQ35079683
Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011Q35130819
New concepts in breast cancer genomics and geneticsQ35258057
Cyclophosphamide dose intensification may circumvent anthracycline resistance of p53 mutant breast cancersQ35583968
A common region of deletion on chromosome 17q in both sporadic and familial epithelial ovarian tumors distal to BRCA1.Q35889414
TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancerQ35906287
TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancerQ35961836
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growthQ36056465
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survivalQ36070080
Mutant p53: one name, many proteinsQ36070574
N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agentsQ36137812
Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancerQ36245541
Estrogen receptor prevents p53-dependent apoptosis in breast cancerQ36397942
The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancerQ36785983
Triple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriersQ36896061
Punctuated evolution of prostate cancer genomesQ36950514
The consequence of oncomorphic TP53 mutations in ovarian cancerQ37225303
APOBEC3B is an enzymatic source of mutation in breast cancer.Q37533713
When mutants gain new powers: news from the mutant p53 field.Q37582777
p53-based cancer therapyQ37750115
Mapping genetic alterations causing chemoresistance in cancer: identifying the roads by tracking the driversQ38087850
p53 in breast cancer subtypes and new insights into response to chemotherapyQ38145813
BRCAness: a deeper insight into basal-like breast tumorsQ38153181
TP53 mutations in human cancer: database reassessment and prospects for the next decadeQ38199075
Unravelling mechanisms of p53-mediated tumour suppressionQ38205099
Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signatureQ39377518
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesisQ40694250
Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivoQ40907746
Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.Q41046980
Full sequencing of TP53 identifies identical mutations within in situ and invasive components in breast cancer suggesting clonal evolutionQ41130119
Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screensQ41905883
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevanceQ42458495
The prognostic significance of p53 tumor suppressor gene alterations in ovarian carcinomaQ44103449
TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancerQ44679253
p53 dependent cell-cycle arrest triggered by chemotherapy in xenografted breast tumors.Q46219717
Whole-genome characterization of chemoresistant ovarian cancer.Q50272478
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.Q51742087
Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.Q52193951
Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship.Q53337533
Molecular Subtypes of High-Grade Serous Ovarian Cancer: The Holy Grail?Q57255835
p53 gene status and response to platinum/paclitaxel-based chemotherapy in advanced ovarian carcinomaQ60936553
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
P577publication date2016-11-04
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleTP53 Mutations in Breast and Ovarian Cancer
P478volume7

Reverse relations

cites work (P2860)
Q924815316-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers
Q64073747Association between TP53 rs1042522 gene polymorphism and the risk of malignant bone tumors: a meta-analysis
Q64242607Association of p53 expression with poor prognosis in patients with triple-negative breast invasive ductal carcinoma
Q89919945Deciphering the Mounting Complexity of the p53 Regulatory Network in Correlation to Long Non-Coding RNAs (lncRNAs) in Ovarian Cancer
Q92503916Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer Diagnosis
Q89862519Genomic Signature of the Standardized Uptake Value in 18F-Fluorodeoxyglucose Positron Emission Tomography in Breast Cancer
Q64987440High α B-crystallin and p53 co-expression is associated with poor prognosis in ovarian cancer.
Q58587067Human Disease Ontology 2018 update: classification, content and workflow expansion
Q55259197Identification of Novel Somatic TP53 Mutations in Patients with High-Grade Serous Ovarian Cancer (HGSOC) Using Next-Generation Sequencing (NGS).
Q92922862Metabolism of Estrogens: Turnover Differs Between Platinum-Sensitive and -Resistant High-Grade Serous Ovarian Cancer Cells
Q58744379Prevalence and spectrum of AKT1, PIK3CA, PTEN and TP53 somatic mutations in Chinese breast cancer patients
Q58792318Survival in males with glioma and gastric adenocarcinoma correlates with mutant p53 residual transcriptional activity
Q37596828The fate of BRCA1-related germline mutations in triple-negative breast tumors

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