An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).

scientific article published on 12 November 2016

An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015). is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1080/13543776.2017.1261111
P698PubMed publication ID27841045

P50authorKunal NepaliQ89110255
Ritu OjhaQ99741360
P2093author name stringSahil Sharma
Jagjeet Singh
Harbinder Singh
Anu Ojha
P2860cites work2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemiaQ24612292
Deciphering the inhibitory mechanism of genistein on xanthine oxidase in vitro.Q53420327
Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors.Q53600813
Microwave assisted synthesis of naphthopyrans catalysed by silica supported fluoroboric acid as a new class of non purine xanthine oxidase inhibitors.Q54373597
Initiation of allopurinol at first medical contact for acute attacks of gout: a randomized clinical trial.Q55056789
Structure and Function of Xanthine OxidoreductaseQ55982356
The influence of electronic, steric and hydrophobic properties of flavonoid compounds in the inhibition of the xanthine oxidaseQ58318980
Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivativesQ59140340
Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinolQ24652967
Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and goutQ27023909
An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibitionQ27639928
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetinQ27694616
Urate-lowering therapy for gout: focus on febuxostatQ28283310
Flavonoid glycosides isolated from unique legume plant extracts as novel inhibitors of xanthine oxidaseQ28481361
A practical approach to gout. Current management of an 'old' diseaseQ33758862
How is gout managed in primary care? A review of current practice and proposed guidelinesQ33884300
Gout update: from lab to the clinic and backQ33914121
Prevention and Management of GoutQ34305913
Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengersQ34455863
Progress towards the discovery of xanthine oxidase inhibitors.Q34541602
Febuxostat compared with allopurinol in patients with hyperuricemia and goutQ34563183
Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjectsQ34584089
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without goutQ34737229
A benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients?Q34797671
Isolation and synthesis of biologically active carbazole alkaloidsQ34995236
Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengersQ36535526
2012 American College of Rheumatology guidelines for management of gout. Part 2: therapy and antiinflammatory prophylaxis of acute gouty arthritisQ36870924
Molecular hybridization: a useful tool in the design of new drug prototypesQ36879306
3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and goutQ37277498
The treatment of hyperuricemiaQ38576552
Development of 2-(Substituted Benzylamino)-4-Methyl-1, 3-Thiazole-5-Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors and Free Radical Scavengers.Q40314317
Population Pharmacokinetics and Therapeutic Efficacy of Febuxostat in Patients with Severe Renal Impairment.Q40727676
Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiencyQ40830127
Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS productionQ42127578
Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia.Q42714465
A comparative study of AutoDock and PMF scoring performances, and SAR of 2-substituted pyrazolotriazolopyrimidines and 4-substituted pyrazolopyrimidines as potent xanthine oxidase inhibitorsQ43206017
Insights into the inhibition of xanthine oxidase by curcuminQ43267657
2-Alkyloxyalkylthiohypoxanthines as new potent inhibitors of xanthine oxidaseQ43838644
Molecular modeling of flavonoids that inhibits xanthine oxidaseQ44021036
The reaction mechanism of xanthine oxidase: evidence for two-electron chemistry rather than sequential one-electron stepsQ44238301
Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinolQ44962055
Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteersQ45167605
Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trialQ46271681
The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidaseQ46477429
6-(N-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: inhibition mechanism and molecular modeling studiesQ46737383
Identification of a potent xanthine oxidase inhibitor from oxidation of caffeic acidQ46935245
Does starting allopurinol prolong acute treated gout? A randomized clinical trialQ48089305
Quick identification of xanthine oxidase inhibitor and antioxidant from Erycibe obtusifolia by a drug discovery platform composed of multiple mass spectrometric platforms and thin-layer chromatography bioautography.Q51076921
Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors.Q51722188
Hypouricemic effect of allopurinol and the novel xanthine oxidase inhibitor TEI-6720 in chimpanzees.Q52846892
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectxanthine oxidase inhibitorQ8042974
P304page(s)311-345
P577publication date2016-11-12
P1433published inExpert Opinion on Therapeutic PatentsQ5421213
P1476titleAn updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).
P478volume27