Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma

scientific article published on February 2015

Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1097/SLA.0000000000000635
P932PMC publication ID4431893
P698PubMed publication ID24646553

P50authorGeorgia BeasleyQ42842714
P2093author name stringMark W Dewhirst
Michael A Davies
Yoshihiro Tokuhisa
Wanleng Deng
Douglas S Tyler
Ryan S Turley
Michael E Lidsky
Hiroaki Toshimitsu
Christina K Augustine
James C Padussis
Andrew Fontanella
P2860cites workKinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAFQ24298749
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthQ27659493
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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapyQ29547379
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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFQ29616828
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RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway.Q40318240
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The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.Q40479888
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumorsQ40550209
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.Q40560244
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cellsQ42478581
Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic MelanomaQ42723115
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Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 casesQ44185238
Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.Q44260429
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A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma.Q45917900
Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatmentQ46593339
Assessing tumor angiogenesis: increased circulating VE-cadherin RNA in patients with cancer indicates viability of circulating endothelial cellsQ47324253
Shifts in cadherin profiles between human normal melanocytes and melanomasQ47971517
IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesisQ53618817
MelanomaQ56428909
Clinical and pharmacological phase I evaluation of ExherinTM (ADH-1), a selective anti-N-cadherin peptide in patients with N-cadherin-expressing solid tumoursQ62944928
Evidence for active transport of melphalan by two amino acid carriers in L5178Y lymphoblasts in vitroQ67017574
Melphalan concentration dependent plasma protein binding in healthy humans and ratsQ69021388
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Predictors and natural history of in-transit melanoma after sentinel lymphadenectomyQ80380578
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)368-377
P577publication date2015-02-01
P1433published inAnnals of SurgeryQ4767866
P1476titleTargeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma
P478volume261

Reverse relations

cites work (P2860)
Q39128697Epithelial-Mesenchymal Expression Phenotype of Primary Melanoma and Matched Metastases and Relationship with Overall Survival
Q26738643Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells
Q57052686N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer
Q37702674N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways
Q47148048One crisis, diverse impacts-Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae.