Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy

scientific article published on 21 November 2016

Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S11064-016-2105-8
P698PubMed publication ID27873132

P50authorMagdalena ZielińskaQ57770276
Jan AlbrechtQ68085265
P2860cites workSystem N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.Q50435953
Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances.Q51392570
Expression of the glutamate transporters in human temporal lobe epilepsy.Q52535111
Magnetic resonance imaging in occipital lobe epilepsy with frequent seizures.Q53651364
Differential molecular regulation of glutamate in kindling resistant rats.Q54398460
Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicityQ62066109
Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosynthesis of transmitter glutamateQ69919248
Subfield-specific loss of hippocampal N-acetyl aspartate in temporal lobe epilepsyQ81151023
Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat modelQ85225569
Glia as drivers of abnormal neuronal activityQ26771699
New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatmentQ27011409
Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG TelemetryQ27303313
The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?Q28248515
Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1Q28294822
Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in ratsQ28369479
Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiationQ28508728
Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytesQ28569155
A distinct set of synaptic-like microvesicles in atroglial cells contain VGLUT3Q28569548
Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmissionQ28571345
Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birthQ28585051
Status EpilepticusQ30277237
Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticusQ30498041
A local glutamate-glutamine cycle sustains synaptic excitatory transmitter releaseQ30577212
Astrocyte-neuronal interactions in epileptogenesis.Q30911884
Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsyQ30974448
Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neuronsQ33223351
Glutamate-induced exocytosis of glutamate from astrocytesQ33288462
Genetic deletion of the neuronal glutamate transporter, EAAC1, results in decreased neuronal death after pilocarpine-induced status epilepticusQ33748210
Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampusQ33763044
Transition to absence seizures and the role of GABA(A) receptorsQ34010417
A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivoQ34018678
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticusQ34048890
Standards for epidemiologic studies and surveillance of epilepsyQ34214261
Self-induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicityQ34310129
Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampusQ34516674
mRNA for the EAAC1 subtype of glutamate transporter is present in neuronal dendrites in vitro and dramatically increases in vivo after a seizureQ34579378
Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle.Q34666719
Review: Hippocampal sclerosis in epilepsy: a neuropathology reviewQ34692930
A Transient Upregulation of Glutamine Synthetase in the Dentate Gyrus Is Involved in Epileptogenesis Induced by Amygdala Kindling in the Rat.Q34794383
Reactive astrogliosis causes the development of spontaneous seizuresQ35117565
Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure‐susceptible DBA/2 miceQ35575596
Disinhibition reduces extracellular glutamine and elevates extracellular glutamate in rat hippocampus in vivoQ35762271
Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytesQ35795750
Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsyQ36083911
Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptorsQ36143776
NMDA receptor binding in focal epilepsiesQ36150214
Mechanisms of glutamate release from astrocytesQ36496696
Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticusQ36610296
Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy.Q36626925
Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsyQ36740346
Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in miceQ36994337
Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesionsQ37039816
Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in ratsQ37300201
Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the "latent period" and other conceptsQ37352151
The potential role of mitochondrial dysfunction in seizure-associated cell death in the hippocampus and epileptogenesisQ37820454
Neuron-astrocyte signaling and epilepsyQ37933859
Roles of glutamine in neurotransmission.Q37948212
Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA.Q38130674
Reduced astrocytic contribution to the turnover of glutamate, glutamine, and GABA characterizes the latent phase in the kainate model of temporal lobe epilepsyQ38370011
Glutamatergic Mechanisms Associated with Seizures and EpilepsyQ38535033
Mitochondrial dysfunction and seizures: the neuronal energy crisisQ38570577
The role of glial-specific Kir4.1 in normal and pathological states of the CNS.Q38767547
The system N transporter SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptorsQ39310133
Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patientsQ40103095
Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examinationQ40709408
Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsyQ41484370
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsyQ41837512
Trafficking of NMDA receptors during status epilepticus: therapeutic implicationsQ42168613
An astrocytic basis of epilepsyQ42218578
Excitotoxic mechanisms of epileptic brain damageQ42220822
Extracellular amino acid levels in hippocampus during pilocarpine-induced seizuresQ42284408
Extracellular metabolites in the cortex and hippocampus of epileptic patientsQ42473420
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsyQ42504378
Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain sliceQ42917672
Imaging of glutamate in brain slices using FRET sensorsQ42931139
Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.Q43681579
Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsyQ43880611
Delayed anoxic depolarizations in hippocampal neurons of mice lacking the excitatory amino acid carrier 1.Q43970041
Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsyQ44035570
Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampusQ44211097
Glial-neuronal interactions following kainate injection in ratsQ44222343
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsyQ44728453
Hippocampal microdialysis during spontaneous intraoperative epileptiform activityQ44764614
Alternative splicing of glutamate transporter EAAT2 RNA in neocortex and hippocampus of temporal lobe epilepsy patientsQ44972162
Reduced glutamine synthetase in hippocampal areas with neuron loss in temporal lobe epilepsyQ45236751
Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice.Q45294943
Chronic electrographic seizure reduces glutamine and elevates glutamate in the extracellular fluid of rat brainQ45300697
Hippocampal distribution of vesicular glutamate transporter 1 in patients with temporal lobe epilepsy.Q46039166
Epilepsy in glioblastoma multiforme: correlation with glutamine synthetase levels.Q46138442
Beneficial effects of ceftriaxone against pentylenetetrazole-evoked convulsionsQ46429016
Metabolism is normal in astrocytes in chronically epileptic rats: a (13)C NMR study of neuronal-glial interactions in a model of temporal lobe epilepsyQ46497519
1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsyQ46544626
Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsyQ46596386
Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsyQ46669920
Excitatory amino acids and epilepsy-induced changes in extracellular space sizeQ47215329
Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brainQ48264889
Altered vesicular glutamate transporter expression in human temporal lobe epilepsy with hippocampal sclerosisQ48335704
Is the underlying cause of epilepsy a major prognostic factor for recurrence?Q48349482
Changes in glial glutamate transporters in human epileptogenic hippocampus: inadequate explanation for high extracellular glutamate during seizuresQ48366532
Spontaneous intracellular calcium oscillations in cortical astrocytes from a patient with intractable childhood epilepsy (Rasmussen's encephalitis).Q48574254
Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetateQ48589672
Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures.Q48633963
Excitatory amino acid transporter 2 downregulation correlates with thalamic neuronal death following kainic acid-induced status epilepticus in rat.Q48639027
Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery programQ48785054
Inducible presynaptic glutamine transport supports glutamatergic transmission at the calyx of Held synapseQ48904325
Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic ratsQ49021651
P433issue6
P304page(s)1724-1734
P577publication date2016-11-21
P1433published inNeurochemical ResearchQ15716728
P1476titleMechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy
P478volume42

Reverse relations

cites work (P2860)
Q50067316Development and validation of a simple, rapid and sensitive LC-MS/MS method for the measurement of urinary neurotransmitters and their metabolites
Q94544485Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Q92942352Imaging epilepsy in larval zebrafish
Q50532305Psychostimulant drug effects on glutamate, Glx, and creatine in the anterior cingulate cortex and subjective response in healthy humans.
Q89302819Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-Through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction
Q89510260The Effect of Protein-Rich Extract from Bombyx Batryticatus against Glutamate-Damaged PC12 Cells Via Regulating γ-Aminobutyric Acid Signaling Pathway

Search more.