Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation.

scientific article published on April 1997

Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.1830270430
P698PubMed publication ID9130657
P5875ResearchGate publication ID14087001

P50authorStephen M. BeverleyQ30505183
Paul M KayeQ59697523
P2093author name stringHarris RA
Graham S
Garcia MR
P2860cites workThe epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptidesQ24339477
A sequential model for peptide binding and transport by the transporters associated with antigen processingQ28236633
Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin EQ28589161
Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide complexes during antigen processingQ33702492
Assembly, transport, and function of MHC class II moleculesQ34328789
Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigenQ34754320
An acid protease secreted by transformed cells interferes with antigen processingQ36218951
Separation of subcellular compartments containing distinct functional forms of MHC class IIQ36233913
Class I-restricted processing and presentation of exogenous cell-associated antigen in vivoQ36350448
Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunizationQ36356200
Detection of functional class II-associated antigen: role of a low density endosomal compartment in antigen processingQ36364817
Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosisQ36365348
Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T cell recognition.Q39125342
Altered course of visceral leishmaniasis in mice expressing transgenic I-E moleculesQ39125351
A modified colorimetric assay of macrophage activation for intracellular cytotoxicity against Leishmania parasitesQ39135299
Presentation ofLeishmania donovani promastigotes occurs via a brefeldin A-sensitive pathwayQ39159612
Pathways for the processing and presentation of antigens to T cellsQ40509383
CD8+ T-cell interactions with Toxoplasma gondii: implications for processing of antigen for class-I-restricted recognition.Q40708644
The involvement of antigen processing in determinant selection by class II MHC and its relationship to immunodominanceQ40780290
MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activationQ40807437
The biochemistry and cell biology of antigen processing and presentationQ40898211
Leishmania-infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4+ T cellsQ41147792
Antigen presentation by Leishmania mexicana-infected macrophages: activation of helper T cells specific for amastigote cysteine proteinases requires intracellular killing of the parasites.Q41353556
Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulumQ41354524
A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I moleculesQ41380874
Antigen-processing organelles from DRB1*1101 and DRB1*1104 B cell lines display a differential degradation activityQ41390416
Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chainQ41422715
Leishmania major infection in mice primes for specific major histocompatibility complex class I-restricted CD8+ cytotoxic T cell responsesQ41431066
Electroporation and commercial liposomes efficiently deliver soluble protein into the MHC class I presentation pathway. Priming in vitro and in vivo for class I-restricted recognition of soluble antigenQ41566059
Recombinant Leishmania surface glycoprotein GP63 is secreted in the baculovirus expression system as a latent metalloproteinaseQ42069351
Structurally distinct genes for the surface protease of Leishmania mexicana are developmentally regulatedQ48139144
Phagocytic processing of bacterial antigens for class I MHC presentation to T cellsQ50167043
Leishmania mexicana promastigotes induce cytotoxic T lymphocytes in vivo that do not recognize infected macrophages.Q54664301
Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysinesQ56967728
Substrate-dependent pH optima of gp63 purified from seven strains of LeishmaniaQ67922334
Leishmania mexicana mexicana gp63 is a site-specific neutral endopeptidaseQ68522028
Leishmania donovani infection in heterozygous and recombinant H-2 haplotype miceQ70992143
Phagocyte-induced antigen-specific activation of unprimed CD8+ T cells in vitroQ71696210
Antigen presentation by Leishmania mexicana-infected macrophages: activation of helper T cells by a model parasite antigen secreted into the parasitophorous vacuole or expressed on the amastigote surfaceQ71930353
Substrate specificity of allelic variants of the TAP peptide transporterQ72641749
Leishmania major: association of the differentially expressed gene B protein and the surface lipophosphoglycan as revealed by membrane cappingQ72798354
The lysosomal gp63-related protein in Leishmania mexicana amastigotes is a soluble metalloproteinase with an acidic pH optimumQ72840642
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1005-1013
P577publication date1997-04-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleEpitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation
P478volume27

Reverse relations

cites work (P2860)
Q34033582Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cells
Q35927465CD8(+) T cells in leishmania infections: friends or foes?
Q58779502Differential induction of cellular responses by live and dead Leishmania promastigotes in healthy donors
Q45920568Dissimilar peptidase production by avirulent and virulent promastigotes of Leishmania braziliensis: inference on the parasite proliferation and interaction with macrophages.
Q39572606Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice.
Q48249997Expression and Function of the Trypanosoma brucei Major Surface Protease (GP63) Genes
Q36903844Functional paradox in host-pathogen interaction dictates the fate of parasites
Q34093793Immune evasive mechanisms contributing to persistent Leishmania donovani infection
Q35845442Immunomodulatory Effects of Four Leishmania infantum Potentially Excreted/Secreted Proteins on Human Dendritic Cells Differentiation and Maturation
Q36260945Macrophage and Leishmania: an unacceptable coexistence
Q33557793Major surface protease of trypanosomatids: one size fits all?
Q36331367Synthetic Peptides as Potential Antigens for Cutaneous Leishmaniosis Diagnosis.
Q33797324The effect of viruses on the ability to present antigens via the major histocompatibility complex
Q35561779The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function.
Q36672756The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function
Q34376021Toxoplasma gondii and MHC-restricted antigen presentation: on degradation, transport and modulation
Q37081691Transgenic Leishmania and the immune response to infection
Q37996396Secreted virulence factors and immune evasion in visceral leishmaniasis.

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