IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure

scientific article published on 17 January 2017

IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CEA.12886
P8608Fatcat IDrelease_mqyy34grcrfcplo2oqbtnpmsmy
P932PMC publication ID5407912
P698PubMed publication ID28093832

P50authorClinton B MathiasQ50283130
P2093author name stringH L Aguila
C A Wu
R S Thrall
C M Schramm
L A Guernsey
S S Schneider
E Secor
J Rovatti
J Ser-Dolansky
S H Polukort
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Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptorQ36363861
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Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cellsQ36369770
Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient MiceQ36370673
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Antigen-specific effector CD8 T cells regulate allergic responses via IFN-γ and dendritic cell function.Q53096589
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Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitisQ77374028
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferationQ77658417
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In vivo evidence for a dependence on interleukin 15 for survival of natural killer cellsQ78410347
IL-15Ralpha is a negative regulator of TCR-activated proliferation in CD4+ T cellsQ80475657
CD8+ T cell-mediated airway hyperresponsiveness and inflammation is dependent on CD4+IL-4+ T cellsQ80819581
CD8+ alphabeta T cells can mediate late airway responses and airway eosinophilia in ratsQ81092770
Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsivenessQ81621929
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The pleiotropic functions of interleukin 15: not so interleukin 2-like after all.Q36375999
Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasisQ36403813
IL-15/IL-15 receptor biology: a guided tour through an expanding universeQ36525063
IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentationQ36640049
Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammationQ36754314
IL-13-producing BLT1-positive CD8 cells are increased in asthma and are associated with airway obstructionQ36778052
Innate lymphoid cells in asthma: Will they take your breath away?Q36973089
IL-15 trans-presentation promotes human NK cell development and differentiation in vivoQ37061837
Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infectionQ37349879
IL-7 and IL-15: biology and roles in T-Cell immunity in health and diseaseQ37376341
IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells.Q37485997
Trans-presentation: a novel mechanism regulating IL-15 delivery and responsesQ37612151
Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expressionQ37682391
Innate and adaptive immune responses in asthmaQ38007827
The unconventional expression of IL-15 and its role in NK cell homeostasisQ38184890
Innate immunity in the lung regulates the development of asthmaQ38221348
Natural killer cells in the development of asthmaQ38287576
Pro-inflammatory role of natural killer cells in the development of allergic airway diseaseQ38727536
NK cells provide helper signal for CD8+ T cells by inducing the expression of membrane-bound IL-15 on DCs.Q39867676
IL-4 and IL-15 promotion of virtual memory CD8+ T cells is determined by genetic backgroundQ40600158
Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cellsQ41773432
Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in miceQ41982292
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammationQ42093185
Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells.Q42128057
Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cellsQ44631842
Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13.Q44757038
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Activated, cytotoxic CD8(+) T lymphocytes contribute to the pathology of asthma deathQ45026530
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivityQ46302049
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthmaQ46413344
CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammationQ47299770
Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivoQ47810986
Differential expression of interleukins IL-13 and IL-15 in normal ovarian tissue and ovarian carcinomasQ48035676
Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation.Q49343536
Resident memory T cells are a Notch above the rest.Q50611431
Editorial: Pulmonary resident memory CD8 T cells: here today, gone tomorrow.Q50862584
Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia.Q51611177
Different NK cell developmental events require different levels of IL-15 trans-presentation.Q51862524
IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells.Q51982055
Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma.Q52022052
Control of homeostasis of CD8+ memory T cells by opposing cytokines.Q52027383
P433issue5
P304page(s)639-655
P577publication date2017-02-07
P1433published inClinical & Experimental AllergyQ5133747
P1476titleIL-15-deficient mice develop enhanced allergic responses to airway allergen exposure
P478volume47

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cites work (P2860)
Q57489440Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study
Q33655744Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis
Q93035947The IL-15 / sIL-15Rα complex modulates immunity without effect on asthma features in mouse

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