ABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines

scientific article published on 24 December 2013

ABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.5681/APB.2014.027
P932PMC publication ID3915819
P698PubMed publication ID24511483

P50authorNosratollah ZarghamiQ47217602
Hassan DariushnejadQ88184357
P2093author name stringMohammad Rahmati
Hossein Jafari Tekab
Masoud Gandomkar Ghalhar
Samaneh Ghasemali
Zahra Davoodi
Zohreh Sadeghi
P2860cites workDownregulation of Bcl-xL and Mcl-1 is sufficient to induce cell death in mesothelioma cells highly refractory to conventional chemotherapyQ39741953
Drug-resistant AML cells and primary AML specimens are killed by 111In-anti-CD33 monoclonal antibodies modified with nuclear localizing peptide sequences.Q39950561
The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatinQ40041107
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.Q40174205
Synergistic effects of troglitazone in combination with cytotoxic agents in acute myelogenous leukaemia cellsQ40279213
Bax-independent inhibition of apoptosis by Bcl-XL.Q41229247
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.Q42064781
ABT-737 overcomes Bcl-2 mediated resistance to doxorubicin-DNA adductsQ43279608
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocationQ44926251
Anthracycline antibiotics induce acute renal tubular toxicity in children with cancerQ46961763
Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapyQ24635408
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.Q33266778
Acute myeloid leukemiaQ33741270
Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteinsQ33921266
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networksQ35743146
The anthracycline antibiotics: antitumor drugs that alter chromatin structureQ35990443
Programmed cell death via mitochondria: different modes of dying.Q36088226
Drug therapy for acute myeloid leukemiaQ36115808
Unique biology of Mcl-1: therapeutic opportunities in cancerQ37108463
Current and emerging therapies for acute myeloid leukemiaQ37683191
The role of cytokines in acute myeloid leukemia: a systematic review.Q38065929
Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cellsQ39360253
Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737.Q39427575
P433issue2
P921main subjectacute myeloid leukemiaQ264118
P304page(s)185-189
P577publication date2013-12-24
P1433published inAdvanced Pharmaceutical BulletinQ26853868
P1476titleABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines
P478volume4

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cites work (P2860)
Q42425463Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC.
Q34436545The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells

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