Piceatannol exhibits selective toxicity to multiple myeloma cells and influences the Wnt/ beta-catenin pathway (scientific article published on 27 January 2014)

Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts

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In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model

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Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma

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Wnt signaling in disease and in development

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

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Wnt signaling: is the party in the nucleus?

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Autologous hematopoietic stem-cell transplantation for multiple myeloma

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Multiple myeloma: evolving genetic events and host interactions

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Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression

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Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma.

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AKT/mTOR as Novel Targets of Polyphenol Piceatannol Possibly Contributing to Inhibition of Proliferation of Cultured Prostate Cancer Cells

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

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Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-α-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-κB pathway

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Investigational treatments for multiple myeloma

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Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

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Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1.

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

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The AKT kinase is activated in multiple myeloma tumor cells

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Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells

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Piceatannol suppresses breast cancer cell invasion through the inhibition of MMP-9: involvement of PI3K/AKT and NF-κB pathways

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In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma

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Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling

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The grape component piceatannol induces apoptosis in DU145 human prostate cancer cells via the activation of extrinsic and intrinsic pathways

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beta-catenin small interfering RNA successfully suppressed progression of multiple myeloma in a mouse model

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Downstream effectors of oncogenic ras in multiple myeloma cells

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Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines.

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Postharvest UV-C-irradiated grapes as a potential source for producing stilbene-enriched red wines

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Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

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TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis

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Production of stilbenoids from the callus of Arachis hypogaea: a novel source of the anticancer compound piceatannol

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Use of potato disc and brine shrimp bioassays to detect activity and isolate piceatannol as the antileukemic principle from the seeds of Euphorbia lagascae

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Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol

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A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma

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P433

issue

P921

main subject

Picea glauca

Picea abies

Abies alba

Picea sitchensis

Picea engelmannii

Picea mariana

multiple myeloma

Picea glehnii

piceatannol

Picea rubens

Picea obovata

page(s)

197-204

P577

publication date

2014-01-27

P1433

published in

Hematological Oncology

Q15762617

P1476

title

Piceatannol exhibits selective toxicity to multiple myeloma cells and influences the Wnt/ beta-catenin pathway

P478

volume

Reverse relations

cites work (P2860)

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Q37697253	Kinase inhibitors as potential agents in the treatment of multiple myeloma
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Q92854662	Overview of Cellular Mechanisms and Signaling Pathways of Piceatannol
Q50451846	Piceatannol inhibits effector T cell functions by suppressing TcR signaling.
Q91270157	Piceatannol-Induced Apoptosis Is Reversed by N-Acetyl-L-cysteine through Restoration of XIAP Expression
Q35811795	Plant stilbenes induce endoplasmic reticulum stress and their anti-cancer activity can be enhanced by inhibitors of autophagy
Q35869295	Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics
Q92079011	Targeting multiple myeloma with natural polyphenols
Q38965212	Therapeutic Potential and Molecular Targets of Piceatannol in Chronic Diseases