Dysregulation of microRNA-34a expression in colorectal cancer inhibits the phosphorylation of FAK via VEGF.

scientific article published on 27 December 2013

Dysregulation of microRNA-34a expression in colorectal cancer inhibits the phosphorylation of FAK via VEGF. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10620-013-2983-4
P698PubMed publication ID24370784

P2093author name stringJianping Zhou
Ming Dong
Danhua Zhang
P2860cites workMicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiationQ24628741
Cancer statistics, 2012Q27860574
Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cellsQ28476781
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent mannerQ33901567
Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patientsQ33986725
Altered expression of the miRNA processing endoribonuclease Dicer has prognostic significance in human cancersQ34319010
1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathwayQ35020469
Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activationQ35622038
VEGF-induced vascular permeability is mediated by FAK.Q35697402
The effect of anti-VEGF drugs (bevacizumab and aflibercept) on the survival of patients with metastatic colorectal cancer (mCRC)Q35938926
Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNAQ36054278
TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.Q36237549
Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF.Q36297343
Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA familyQ36435782
Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesisQ36580378
MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-AQ36642299
Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer StudyQ37243915
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferationQ37381921
MicroRNAs in colorectal cancer metastasis.Q37894616
The hunting of targets: challenge in miRNA researchQ38029965
Delivering the promise of miRNA cancer therapeuticsQ38051968
Ectopic expression of miR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathwayQ39204898
miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44.Q39211497
Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repressionQ39249155
Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cellsQ39375782
Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancerQ39592978
Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cellsQ39932777
Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrestQ39992760
Signal transduction from the extracellular matrix--a role for the focal adhesion protein-tyrosine kinase FAK.Q41444818
Search for potential gastric cancer markers using miRNA databases and gene expression analysisQ48040182
miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer.Q53306726
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
phosphorylationQ242736
microRNAQ310899
colorectal carcinomaQ25493920
P304page(s)958-967
P577publication date2013-12-27
P1433published inDigestive Diseases and SciencesQ15716711
P1476titleDysregulation of microRNA-34a expression in colorectal cancer inhibits the phosphorylation of FAK via VEGF.
P478volume59

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cites work (P2860)
Q58776119A comprehensive investigation using meta-analysis and bioinformatics on miR-34a-5p expression and its potential role in head and neck squamous cell carcinoma
Q54976490Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development.
Q47224057MiR-34a regulates the invasive capacity of canine osteosarcoma cell lines
Q28395657MiR-590-5p inhibits colorectal cancer angiogenesis and metastasis by regulating nuclear factor 90/vascular endothelial growth factor A axis
Q28384675MicroRNA-106b promotes colorectal cancer cell migration and invasion by directly targeting DLC1
Q61800287MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer
Q39390383MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy
Q50623650Regulatory effect of microRNA-34a on osteogenesis and angiogenesis in glucocorticoid-induced osteonecrosis of the femoral head.
Q90320692TGF-β secreted by tumor-associated macrophages promotes proliferation and invasion of colorectal cancer via miR-34a-VEGF axis
Q37041036The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas.
Q33816414Verification of microRNA expression in human endometrial adenocarcinoma.
Q88912661miR‑1 inhibits the progression of colon cancer by regulating the expression of vascular endothelial growth factor

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