The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling

scientific article published on 2 December 2013

The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.499194
P932PMC publication ID3894321
P698PubMed publication ID24297182

P2093author name stringMarc Goethals
Jan Tavernier
Mohamed Lamkanfi
Lieselotte Vande Walle
Sven Eyckerman
Frank Peelman
Sarah Gerlo
Celia Bovijn
Tim Van Acker
P2860cites workARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangementsQ21632356
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transductionQ24291653
Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1Q24306419
Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesisQ24321408
AIP1 functions as Arf6-GAP to negatively regulate TLR4 signalingQ24323383
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signalingQ24337616
Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcriptionQ24530567
Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.Q24533140
TLR signaling pathwaysQ24570127
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIFQ24672442
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophagesQ24675747
Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: pushing pixels to explore biological phenomenaQ24681432
A new technique for the assay of infectivity of human adenovirus 5 DNAQ27860797
MAPPIT analysis of TLR adaptor complexesQ28116168
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formationQ28139699
TIRAP: an adapter molecule in the Toll signaling pathwayQ28214613
TLR signalingQ28291637
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomesQ28295227
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-betaQ28506630
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptorsQ28511605
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signalingQ28593045
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4Q28594101
Toll-like receptor control of the adaptive immune responsesQ29547305
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase DQ30307678
Regulators and effectors of the ARF GTPases.Q33954573
DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanismQ34107593
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.Q34160547
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.Q34266420
A regulatory role for ARF6 in receptor-mediated endocytosisQ34318574
A practical guide to evaluating colocalization in biological microscopyQ34782140
Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interferenceQ35182317
Pivotal role of ADP-ribosylation factor 6 in Toll-like receptor 9-mediated immune signalingQ35763211
ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathwayQ36273935
ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigationQ36274890
TLR9-mediated ARF6 activation is involved in advancing CpG ODN cellular uptakeQ36287247
ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophagesQ36323565
Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptakeQ36371628
MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.Q37433320
IKKepsilon: a kinase at the intersection of signaling and membrane traffic.Q37889543
Lactobacillus plantarum reduces Streptococcus pyogenes virulence by modulating the IL-17, IL-23 and Toll-like receptor 2/4 expressions in human epithelial cells.Q39119521
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.Q39246542
Foxp3 expression in A549 cells is regulated by Toll-like receptor 4 through nuclear factor-κB.Q39350288
RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain sheddingQ39580605
Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction siteQ39756100
Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartmentQ39760408
Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signalingQ40020382
Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).Q40132444
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistanceQ40196763
Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transportQ40306814
The GDP-bound form of Arf6 is located at the plasma membraneQ40558974
Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11.Q40607521
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta inductionQ40675827
A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophagesQ41020756
Regulation of type I interferon gene expression by interferon regulatory factor-3.Q41063455
IKKε regulates cell elongation through recycling endosome shuttling.Q47072558
Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2.Q49046560
MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.Q50053416
A role for ARF6 in dendritic cell podosome formation and migration.Q50645600
ARF6 GTPase controls bacterial invasion by actin remodellingQ56922088
Regulated exocytosis in chromaffin cells. A potential role for a secretory granule-associated ARF6 proteinQ73009352
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)1364-1376
P577publication date2013-12-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling
P478volume289