Saturated fatty acids up-regulate COX-2 expression in prostate epithelial cells via toll-like receptor 4/NF-κB signaling

scientific article published on April 2014

Saturated fatty acids up-regulate COX-2 expression in prostate epithelial cells via toll-like receptor 4/NF-κB signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10753-013-9760-6
P698PubMed publication ID24221358

P2093author name stringFeng Xie
Jie Liu
Qian Zhang
Jie Jin
Yun Cui
Meng-Kui Sun
Shuai Hu
P2860cites workCancer statistics, 2013Q27860762
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COX-2 expression predicts prostate-cancer outcome: analysis of data from the RTOG 92-02 trialQ31130013
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Dietary fat, fatty acids, and risk of prostate cancer in the NIH-AARP diet and health studyQ34031696
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Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men.Q34768696
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI.Q35572582
The burden of prostate cancer in Asian nationsQ35890708
Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles CountyQ35984786
Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways.Q36145284
Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and ObesityQ36469104
Signalling networks regulating cyclooxygenase-2.Q36483419
Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrenceQ38438329
Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53.Q39241785
A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signalingQ39362628
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytesQ40266335
Inhibition of cyclooxygenase (COX)-2 expression by Tet-inducible COX-2 antisense cDNA in hormone-refractory prostate cancer significantly slows tumor growth and improves efficacy of chemotherapeutic drugsQ40483308
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.Q40816506
The effects of omega-3 and omega-6 fatty acids on in vitro prostate cancer growth.Q41222375
A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancerQ41460209
Detoxification of bacterial lipopolysaccharides (endotoxins) by a human neutrophil enzymeQ42217173
Expression of cyclooxygenase-1 and cyclooxygenase-2 in the human prostateQ42494161
Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-alpha in normal and malignant prostate cells.Q42502473
Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma.Q42514552
Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse modelQ42734159
Dietary fat and early-onset prostate cancer riskQ43457233
Incidence of adenocarcinoma of the prostate in Asian immigrants to the United States and their descendantsQ44508784
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acidsQ44514690
Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4.Q44945237
Plasma phospholipid fatty acids, dietary fatty acids and prostate cancer riskQ45350463
Trends in mortality from cancers of the breast, colon, prostate, esophagus, and stomach in East Asia: role of nutrition transition.Q50516395
Expression of cyclooxygenase-2 in prostate carcinoma.Q53407074
Prognostic relevance of cyclooxygenase-2 (COX-2) expression in Chinese patients with prostate cancer.Q54458702
Over-expression of cyclooxygenase-2 in human prostate adenocarcinomaQ73223395
Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancerQ73776417
Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasiaQ73984296
Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase-2, Bcl-2, and cell proliferation in the glandular epitheliumQ80403759
Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancerQ81707914
COX-2 is overexpressed in primary prostate cancer with metastatic potential and may predict survival. A comparison study between COX-2, TGF-beta, IL-10 and Ki67Q84088624
Saturated fatty acids do not directly stimulate Toll-like receptor signalingQ84365640
P433issue2
P921main subjectfatty acidQ61476
toll-like receptorQ408004
NF-κBQ411114
P304page(s)467-477
P577publication date2014-04-01
P1433published inInflammationQ2560341
P1476titleSaturated fatty acids up-regulate COX-2 expression in prostate epithelial cells via toll-like receptor 4/NF-κB signaling
P478volume37