Diacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells.

scientific article published on 20 December 2016

Diacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCISIGNAL.AAF7714
P698PubMed publication ID27999176

P50authorIsabel MéridaQ58320731
Elena AndradaQ84790181
P2093author name stringSilvia Carrasco
Yolanda R Carrasco
Julia Sáez de Guinoa
Sara V Merino-Cortes
María Almena
Rosa Liébana
Raquel Arcos
P2860cites workShaping up the membrane: diacylglycerol coordinates spatial orientation of signaling.Q37907586
Membrane fission: the biogenesis of transport carriersQ37998566
Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functionsQ38447171
TCR-induced activation of Ras proceeds at the plasma membrane and requires palmitoylation of N-Ras.Q39666904
Thymic selection threshold defined by compartmentalization of Ras/MAPK signallingQ39773899
Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicityQ39938302
A flow cytometry procedure for simultaneous characterization of cell DNA content and expression of intracellular protein kinase C-zetaQ40237429
Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipidsQ41410908
Translocation dynamics of sorting nexin 27 in activated T cellsQ42483698
Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cellsQ45409815
Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase CthetaQ50335802
Diacylglycerol-induced Membrane Targeting and Activation of Protein Kinase CϵQ58006829
Diacylglycerol and Protein Kinase D Localization during T Lymphocyte ActivationQ58032675
T cell activationQ24658051
Cell polarisation and the immunological synapseQ26862236
Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapseQ27329909
Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomesQ27673759
The immunological synapse: a molecular machine controlling T cell activationQ28139151
Enhanced T cell responses due to diacylglycerol kinase zeta deficiencyQ28190001
Protein kinase C: poised to signalQ28265620
Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recyclingQ28292379
Selective modulation of protein kinase C-theta during T-cell activationQ28300613
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1Q28567633
T cell receptor antagonist peptides induce positive selectionQ29618820
Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.Q30414445
A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cellsQ30501409
An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse.Q30538802
The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signalingQ33894273
Diacylglycerol kinase ζ limits the generation of natural regulatory T cellsQ33920473
Positive and negative selection of T cellsQ34157557
Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.Q34360144
Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responsesQ34568402
Digital signaling and hysteresis characterize ras activation in lymphoid cellsQ34929087
Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.Q35551761
FoxO-dependent regulation of diacylglycerol kinase α gene expressionQ36276757
Phosphatidic acid- and phosphatidylserine-binding proteinsQ36453653
Diacylglycerol, when simplicity becomes complex.Q36678145
Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinasesQ36941051
Hunter to gatherer and back: immunological synapses and kinapses as variations on the theme of amoeboid locomotionQ37206216
The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapseQ37468145
Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosisQ37486482
Insights into the initiation of TCR signalingQ37580455
Polarity and endocytosis: reciprocal regulationQ37759597
P433issue459
P304page(s)ra127
P577publication date2016-12-20
P1433published inScience SignalingQ7433604
P1476titleDiacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells
P478volume9

Reverse relations

cites work (P2860)
Q47126632Aplastic anemia is related to alterations in T cell receptor signaling
Q47095791SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes

Search more.