5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors

scientific article published on 20 August 2013

5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMC.2013.08.023
P932PMC publication ID3930610
P698PubMed publication ID24120088

P50authorMichael J DappQ57555080
Lauren BeachQ59784284
P2093author name stringLouis M Mansky
Richard H Heineman
Jonathan M Rawson
Steven E Patterson
Jessica L Martin
Erica K Schnettler
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Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptaseQ29619994
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Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rateQ33784748
Exploiting drug repositioning for discovery of a novel HIV combination therapyQ34124794
5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.Q35000909
Viral error catastrophe by mutagenic nucleosidesQ35919839
Lethal mutagenesis of HIV.Q36008905
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferaseQ36145017
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Chemical decomposition of 5-aza-2'-deoxycytidine (Decitabine): kinetic analyses and identification of products by NMR, HPLC, and mass spectrometry.Q37700645
Clinical trials of resveratrolQ37831946
Resveratrol and health--a comprehensive review of human clinical trialsQ37891928
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5-Azacytidine Hydrolysis Kinetics Measured by High-Pressure Liquid Chromatography and 13C-NMR SpectroscopyQ39554910
Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotidesQ40110178
Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical MutagenesisQ40110327
Combination of a mutagenic agent with a reverse transcriptase inhibitor results in systematic inhibition of HIV-1 infectionQ40412986
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesisQ40423448
Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV).Q40653667
Mutational analysis of HIV-1 long terminal repeats to explore the relative contribution of reverse transcriptase and RNA polymerase II to viral mutagenesisQ40714016
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Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiationQ41640905
Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2',3'-dideoxynucleosidesQ42282585
Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replicationQ42282677
Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabineQ42400705
Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrolQ43511988
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagenQ43545743
Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerasesQ43812620
Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification methodQ46980232
Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.Q54122138
Action of 2',2'-difluorodeoxycytidine on DNA synthesisQ67702699
Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosineQ68408993
Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesisQ68917155
2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductaseQ70215052
Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelatorsQ72639469
High-performance Liquid Chromatographic Analysis of Chemical Stability of 5-aza-2′-DeoxycytidineQ72650148
Resveratrol, a remarkable inhibitor of ribonucleotide reductaseQ74191674
Safety, Tolerability, and Pharmacokinetics of KP-1461 in Phase I Clinical Studies: A Single Oral Dose Study in Non-HIV-Infected Adults, and a 14-Day Dose-Escalating Study in Highly Antiretroviral-Experienced HIV-Infected AdultsQ84142908
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)7222-7228
P577publication date2013-08-20
P1433published inBioorganic & Medicinal ChemistryQ2904200
P1476title5,6-Dihydro-5-aza-2'-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors
P478volume21

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cites work (P2860)
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