The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration

scientific article published on 17 January 2017

The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration is …
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scholarly articleQ13442814

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P356DOI10.3945/AN.116.013177
P932PMC publication ID5227975
P698PubMed publication ID28096126

P2093author name stringPaul S Bernstein
Kelly Nelson
Aruna Gorusupudi
P2860cites workVitamin E supplementation and macular degeneration: randomised controlled trialQ24531484
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8Q24544001
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9Q24546140
Complement factor H polymorphism in age-related macular degenerationQ24553334
Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19Q24554181
Identification of StARD3 as a lutein-binding protein in the macula of the primate retinaQ24628314
A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal functionQ24628705
Association between dietary fat intake and age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an ancillary study of the Women's Health InitiativeQ24628833
Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular StudyQ24647967
Age-related macular degeneration: Complement in actionQ26770250
Lipofuscin-formation in retinal pigment epithelial cells is reduced by antioxidantsQ43664504
Dietary fat and risk for advanced age-related macular degenerationQ43694046
Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye StudyQ43830961
Age-related changes in the morphology, absorption and fluorescence of melanosomes and lipofuscin granules of the retinal pigment epitheliumQ43873957
Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models.Q44198727
Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA studyQ44212321
Early age-related maculopathy in the cardiovascular health studyQ44268950
The relationship of ocular factors to the incidence and progression of age-related maculopathyQ44412742
Lutein and zeaxanthin status and risk of age-related macular degeneration.Q44453108
High concentrations of plasma n3 fatty acids are associated with decreased risk for late age-related macular degenerationQ44535356
Age-related macular degeneration. Macular changes, prevalence and sex ratio. An epidemiological study of 1000 aged individualsQ44799844
Treatment response to antioxidants and zinc based on CFH and ARMS2 genetic risk allele number in the Age-Related Eye Disease StudyQ44915960
Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye.Q45050501
The singlet oxygen and carotenoid interactionQ45187333
Six-year supplementation with alpha-tocopherol and beta-carotene and age-related maculopathyQ45248873
Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study.Q46015886
Nutritional AMD treatment phase I (NAT-1): feasibility of oral DHA supplementation in age-related macular degenerationQ46175309
Reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degenerationQ46321294
Macular pigment and visual performance under glare conditionsQ46736128
Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.Q46799572
Effect of simultaneous, single oral doses of beta-carotene with lutein or lycopene on the beta-carotene and retinyl ester responses in the triacylglycerol-rich lipoprotein fraction of men.Q47842512
beta-Carotene: an unusual type of lipid antioxidantQ47860141
Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study.Q50495466
Risk factors for age-related macular degeneration: Pooled findings from three continents.Q50506048
The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.Q50511473
Dietary antioxidants and age-related maculopathy: the Blue Mountains Eye Study.Q50519339
Iris color, skin sun sensitivity, and age-related maculopathy. The Blue Mountains Eye Study.Q50523104
Senile macular degeneration: a case-control study.Q50927753
Dietary omega-3 fatty acids and the risk for age-related maculopathy: the Alienor Study.Q51554097
Are antioxidants or supplements protective for age-related macular degeneration?Q51596706
Five heavy metallic elements and age-related macular degeneration: Korean National Health and Nutrition Examination Survey, 2008-2011.Q53260001
Light exposure and the risk of age-related macular degeneration: the Pathologies Oculaires Liées à l'Age (POLA) study.Q53321018
Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration.Q53529956
Manganese superoxide dismutase gene (SOD2) polymorphism and exudative age-related macular degeneration in the Japanese population.Q54527531
Combined Optic Neuropathy and Myelopathy Secondary to Copper DeficiencyQ56552179
Homocysteine, folate, vitamin B-12, and 10-y incidence of age-related macular degenerationQ57103122
The Grading and Prevalence of Macular Degeneration in Chesapeake Bay WatermenQ57245152
Acceleration of Age-Related Changes in the Retina in α-Tocopherol Transfer Protein Null Mice Fed a Vitamin E–Deficient DietQ57669476
Dose-Ranging Study of Lutein Supplementation in Persons Aged 60 Years or OlderQ59325038
Associations Between Intermediate Age-Related Macular Degeneration and Lutein and Zeaxanthin in the Carotenoids in Age-Related Eye Disease Study (CAREDS)Q63344335
Interaction of Fe3+, Cu2+ and Zn2+ with melanin and melanoproteins from bovine eyesQ67941294
Oral zinc in macular degenerationQ68126625
Prevalence of age-related maculopathy. The Beaver Dam Eye StudyQ68207448
The regional distribution of vitamins E and C in mature and premature human retinasQ68249436
Analysis of the macular pigment by HPLC: retinal distribution and age studyQ68367274
Choroidal neovascularizationQ68983919
Polyunsaturated fatty acids and vitamin E in rat rod outer segments during light damageQ69490668
Sunlight and age-related macular degeneration. The Beaver Dam Eye StudyQ70655027
Antioxidant status and neovascular age-related macular degeneration. Eye Disease Case-Control Study GroupQ72068439
The prevalence of age-related maculopathy in the Rotterdam StudyQ72560755
Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye StudyQ74805233
Serum vitamin E levels negatively correlate with severity of age-related macular degenerationQ77373882
Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degenerationQ79896842
Age-related macular degeneration is the leading cause of blindness...Q79989973
Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA StudyQ83839560
Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degenerationQ39575237
Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.Q39926724
Prevalence of age-related macular degeneration in the US populationQ39966032
The roles of vitamin E and unsaturated fatty acids in the visual processQ40081578
Accumulation and retention of micellar beta-carotene and lutein by Caco-2 human intestinal cellsQ40493188
Oxy-radicals and cancerQ40625911
Whole blood selenium in exudative age-related maculopathyQ40863368
Structure and properties of carotenoids in relation to functionQ40928254
Beta-carotene, carotenoids, and disease prevention in humans.Q40989710
Biological activities of natural and synthetic carotenoids: induction of gap junctional communication and singlet oxygen quenching.Q41140948
Retinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium.Q41349187
Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention StudyQ41654781
Distribution of copper and zinc in mammalian eyes. Occurrence of metals in melanin fractions from eye tissuesQ42106153
Age-related maculopathy and sunlight exposure evaluated by objective measurementQ42288688
Softening of drusen and subretinal neovascularizationQ42448118
Failure of vitamin E to protect the retina against damage resulting from bright cyclic light exposureQ42505055
Competitive inhibition of carotenoid transport and tissue concentrations by high dose supplements of lutein, zeaxanthin and beta-caroteneQ43191416
Macular pigment in donor eyes with and without AMD: a case-control study.Q43514008
Racial differences in the prevalence of age-related macular degeneration: the Baltimore Eye SurveyQ43587787
The Relationship of Dietary Carotenoid and Vitamin A, E, and C Intake With Age-Related Macular Degeneration in a Case-Control StudyQ28248143
Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular DegenerationQ28290149
Prevalence of age-related macular degeneration in the United StatesQ29614964
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokersQ29616096
Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular diseaseQ30693939
Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regressionQ30761426
Prospective study of dietary fat and the risk of age-related macular degenerationQ31827376
Risk factors for age-related macular degenerationQ31926371
Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye.Q31951685
Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination surveyQ32066253
Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in miceQ33295301
Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathyQ33539123
Omega-3 long-chain polyunsaturated fatty acid intake inversely associated with 12-year progression to advanced age-related macular degenerationQ33613360
The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23Q33613367
Essential fatty acids in health and chronic diseaseQ33729708
Oxidative damage and age-related macular degenerationQ33774187
Dietary factors that affect the bioavailability of carotenoidsQ33854110
Acute and bilateral blindness due to optic neuropathy associated with copper deficiencyQ33946258
Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial).Q33977885
Association of macular pigment density with plasma ω-3 fatty acids: the PIMAVOSA studyQ34138412
Drusen and disciform macular detachment and degenerationQ34205929
Senile macular degeneration: a histopathologic studyQ34209340
Carotenoids in the retina and lens: possible acute and chronic effects on human visual performanceQ34255912
Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study GroupQ34323879
Stereochemistry of the human macular carotenoids.Q34364881
Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populationsQ34388840
Fasting plasma zeaxanthin response to Fructus barbarum L. (wolfberry; Kei Tze) in a food-based human supplementation trial.Q34393077
Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy TrialQ34405938
Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study complianceQ34405945
Dietary intake of antioxidants and risk of age-related macular degenerationQ34479951
Bioaccessibility of carotenoids and vitamin E from their main dietary sourcesQ34579944
High dose zinc increases hospital admissions due to genitourinary complicationsQ34601776
Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye StudyQ34657635
Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitaminsQ34719127
Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA studyQ34733171
Genetic testing in persons with age-related macular degeneration and the use of the AREDS supplements: to test or not to test?Q34778837
Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration.Q34805968
Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic StrategiesQ35126780
Regression of choroidal neovascularization results in macular atrophy in anti-vascular endothelial growth factor-treated eyes.Q35251134
Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisationQ35761464
The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retinaQ35957608
Treatment of exudative age-related macular degeneration: many factors to considerQ36088574
Challenges to understanding and measuring carotenoid bioavailabilityQ36159330
Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye CenterQ36239449
Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3Q36257030
The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)Q36360812
The role of inflammation in the pathogenesis of age-related macular degenerationQ36405906
Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular DegenerationQ36468066
Age-Related Macular Degeneration and Blindness due to Neovascular MaculopathyQ36592901
Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkersQ36617497
Prospective study of lutein/zeaxanthin intake and risk of age-related macular degenerationQ36825090
Retinal carotenoids can attenuate formation of A2E in the retinal pigment epitheliumQ37196292
Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)Q37298565
Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohortQ37321510
Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's diseaseQ37328906
Changes in iron-regulatory proteins in the aged rodent neural retinaQ37462408
The role of complement Factor H in age-related macular degeneration: a review.Q37729464
Implications of altered iron homeostasis for age-related macular degeneration.Q37825219
Consequences of oxidative stress in age-related macular degenerationQ38003229
Iron, zinc, and copper in retinal physiology and diseaseQ38155606
Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990-2010.Q38199083
Causes of vision loss worldwide, 1990-2010: a systematic analysisQ38238049
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.Q38238059
An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases.Q38370798
Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular DiseaseQ38456171
Sunlight exposure, antioxidants, and age-related macular degenerationQ39006183
Blueberry anthocyanins: protection against ageing and light-induced damage in retinal pigment epithelial cellsQ39454765
Increased Macular Pigment Optical Density and Visual Acuity following Consumption of a Buttermilk Drink Containing Lutein-Enriched Egg Yolks: A Randomized, Double-Blind, Placebo-Controlled TrialQ39533399
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecteye diseaseQ3041498
P304page(s)40-53
P577publication date2017-01-17
P1433published inAdvances in NutritionQ20821073
P1476titleThe Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration
P478volume8

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cites work (P2860)
Q64901264A Critical Appraisal of National and International Clinical Practice Guidelines Reporting Nutritional Recommendations for Age-Related Macular Degeneration: Are Recommendations Evidence-Based?
Q58554131Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
Q52657692Carotenoid supplementation and retinoic acid in immunoglobulin A regulation of the gut microbiota dysbiosis.
Q91924792Carotenoids: How Effective Are They to Prevent Age-Related Diseases?
Q47782065Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B12-Deprivation Optic Neuropathy
Q64930030Effect of Long-Term Xanthophyll and Anthocyanin Supplementation on Lutein and Zeaxanthin Serum Concentrations and Macular Pigment Optical Density in Postmenopausal Women.
Q92203836Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Eyes With Pigment Epithelial Detachments Due to Age-Related Macular Degeneration
Q91660747Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions
Q93102835Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases
Q55241036Patterns of Fundus Autofluorescence Lifetimes In Eyes of Individuals With Nonexudative Age-Related Macular Degeneration.
Q55054391Qualitative assessment of online information about age-related macular degeneration available in Portuguese.
Q59446743What do we know about the macular pigment in AMD: the past, the present, and the future

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