A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.

scientific article published on 29 March 2011

A small molecule AMPK activator protects the heart against ischemia-reperfusion injury. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2011.03.003
P932PMC publication ID4005884
P698PubMed publication ID21402077
P5875ResearchGate publication ID50394279

P50authorEdward J MillerQ57219754
P2093author name stringKei Sakamoto
Ji Li
Lawrence H Young
Dake Qi
Vlad Zaha
Kwame Atsina
Agnes S Kim
Tracy M Wright
P2860cites workMetabolic actions of metformin in the heart can occur by AMPK-independent mechanismsQ22241963
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP bindingQ22253261
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemiaQ24290495
Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase SignalingQ27832095
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesisQ28218978
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398Q28237559
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardiumQ28304462
AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stressQ28570993
Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heartQ28574917
Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cellsQ28609892
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chainQ29615210
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanismsQ33688706
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy stateQ33968008
AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channelsQ36247802
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.Q36301403
Demonstration of an early and a late phase of ischemic preconditioning in miceQ36982103
Stunning, hibernation, and assessment of myocardial viabilityQ37048921
AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectinQ37135564
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injuryQ37286204
AMPK in Health and DiseaseQ37543855
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.Q38298758
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndromeQ38312576
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent mannerQ39707409
Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusionQ39773528
AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPaseQ39787435
A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanismQ39966490
Infarct size and nitric oxide synthase in murine myocardiumQ40780440
Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injuryQ41273156
ATP-sensitive K(+) channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytesQ44138433
Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotectionQ44763894
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyteQ44907827
Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscleQ44987298
Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transitionQ45140518
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.Q46236023
Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged heartsQ46476112
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.Q46781819
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signalingQ46847423
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.Q51057544
High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylaseQ71892100
Acadesine extends the window of protection afforded by ischaemic preconditioningQ72399886
AMP-activated protein kinase phosphorylation of endothelial NO synthaseQ74456171
Temperature preconditioning of isolated rat hearts--a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition poreQ80065024
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectreperfusion injuryQ1413991
P304page(s)24-32
P577publication date2011-03-29
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleA small molecule AMPK activator protects the heart against ischemia-reperfusion injury
P478volume51