Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models

scientific article published on 12 July 2013

Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CANLET.2013.07.007
P8608Fatcat IDrelease_my4tclzyvzew7mfwypo7pnpscq
P698PubMed publication ID23856031
P5875ResearchGate publication ID249646983

P2093author name stringYuji Yamamoto
Kazuma Takase
Masao Iwata
Kotaro Kodama
Akihiko Tsuruoka
Kiyoshi Okamoto
Naoko Hata Sugi
P2860cites workThe Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)97-103
P577publication date2013-07-12
P1433published inCancer LettersQ326372
P1476titleAntitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models
P478volume340

Reverse relations

cites work (P2860)
Q52668428A Case of Squamous Cell Carcinoma of Unknown Primary that Responded to the Multi-Tyrosine Kinase Inhibitor Lenvatinib.
Q49226937A perspective on multi-target drug discovery and design for complex diseases.
Q36716739A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment
Q92915641Acquired ALK and RET Gene Fusions as Mechanisms of Resistance to Osimertinib in EGFR-Mutant Lung Cancers
Q34253418Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models
Q37393234Characterization of Tumor Size Changes Over Time From the Phase 3 Study of Lenvatinib in Thyroid Cancer
Q53520555Clinical Pharmacokinetic and Pharmacodynamic Profile of Lenvatinib, an Orally Active, Small-Molecule, Multitargeted Tyrosine Kinase Inhibitor.
Q47863818Clinical guidance for radioiodine refractory differentiated thyroid cancer.
Q39442851Clinical use of lenvatinib in combination with everolimus for the treatment of advanced renal cell carcinoma.
Q58710790Combined effects of Lenvatinib and iodine-131 on cell apoptosis in nasopharyngeal carcinoma through inducing endoplasmic reticulum stress
Q100465021Correlative serum biomarker analyses in the phase 2 trial of lenvatinib-plus-everolimus in patients with metastatic renal cell carcinoma
Q38823954Current Standards in Treatment of Radioiodine Refractory Thyroid Cancer
Q42680724Defining Radioiodine-Refractory Differentiated Thyroid Cancer: Efficacy and Safety of Lenvatinib by Radioiodine-Refractory Criteria in the SELECT Trial.
Q92100362Dexamethasone and lenvatinib inhibit migration and invasion of non-small cell lung cancer by regulating EKR/AKT and VEGF signal pathways
Q41992834Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization
Q38754388Dose Finding of Lenvatinib in Subjects With Advanced Hepatocellular Carcinoma Based on Population Pharmacokinetic and Exposure-Response Analyses
Q38612008Drug safety evaluation of lenvatinib for thyroid cancer.
Q34558883E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts
Q38843403Efficacy of lenvatinib in treating thyroid cancer.
Q38172608Emerging protein kinase inhibitors for non-small cell lung cancer
Q38630967Evaluation of in vitro and in vivo activity of a multityrosine kinase inhibitor, AL3810, against human thyroid cancer
Q36189141Fibroblast growth factor family aberrations in cancers: clinical and molecular characteristics
Q57809492Focal segmental glomerulosclerosis lesion associated with inhibition of tyrosine kinases by lenvatinib: a case report
Q52609129Genetic analysis of 779 advanced differentiated and anaplastic thyroid cancers.
Q64091327Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Opportunities and Challenges
Q98665205Immunotherapy for advanced thyroid cancers - rationale, current advances and future strategies
Q47104655In vitro and in vivo anti-tumor activity of alectinib in tumor cells with NCOA4-RET.
Q37723370Incidence and timing of common adverse events in Lenvatinib-treated patients from the SELECT trial and their association with survival outcomes
Q64097520Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer
Q90299970Lenvatinib Plus Pembrolizumab in Patients With Advanced Endometrial Cancer
Q90331084Lenvatinib for Anaplastic Thyroid Cancer and Lenvatinib-Induced Thyroid Dysfunction
Q37672425Lenvatinib for Anaplastic Thyroid Cancer.
Q38754614Lenvatinib for use in combination with everolimus for the treatment of patients with advanced renal cell carcinoma following one prior anti-angiogenic therapy
Q89647095Lenvatinib in Management of Solid Tumors
Q54111915Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models.
Q92684130Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial
Q92486987Lenvatinib promotes antitumor immunity by enhancing the tumor infiltration and activation of NK cells
Q30249385Lenvatinib therapy for the treatment of patients with advanced renal cell carcinoma
Q64073094Lenvatinib, a molecule with versatile application: from preclinical evidence to future development in anti-cancer treatment
Q59571527Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial
Q64880175Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers.
Q38729953Lenvatinib: A Review in Refractory Thyroid Cancer
Q26775043Lenvatinib: Role in thyroid cancer and other solid tumors
Q38385844Lenvatinib: first global approval
Q38653663Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches
Q46573222Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison
Q55617920Method validation studies and an inter-laboratory cross validation study of lenvatinib assay in human plasma using LC-MS/MS.
Q90194104Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice
Q35136424Molecularly targeted therapies in non-small-cell lung cancer annual update 2014
Q35434188Multitarget inhibitors derived from crosstalk mechanism involving VEGFR2.
Q92255821NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells
Q27853306NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer
Q58784257Navigating Systemic Therapy in Advanced Thyroid Carcinoma: From Standard of Care to Personalized Therapy and Beyond
Q96303462New Therapies for Advanced Thyroid Cancer
Q38949133New therapeutic perspectives in CCDC6 deficient lung cancer cells
Q38260495Novel therapies for thyroid cancer
Q89737237Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action
Q36825455Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma
Q36924717Population pharmacokinetic analysis of lenvatinib in healthy subjects and patients with cancer
Q55413273Prolonged duration of response in lenvatinib responders with thyroid cancer.
Q93202753Prospects of multitarget drug designing strategies by linking molecular docking and molecular dynamics to explore the protein-ligand recognition process
Q59136613RET rearrangements are actionable alterations in breast cancer
Q33433315Safety and efficacy profile of lenvatinib in cancer therapy: a systematic review and meta-analysis
Q92755252Second-line lenvatinib in patients with recurrent endometrial cancer
Q89947364Sequential Analysis of Neutrophil-to-lymphocyte Ratio for Differentiated Thyroid Cancer Patients Treated With Lenvatinib
Q26751274Spotlight on lenvatinib in the treatment of thyroid cancer: patient selection and perspectives
Q36467394Subgroup analysis of Japanese patients in a phase 3 study of lenvatinib in radioiodine-refractory differentiated thyroid cancer
Q47601932Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes
Q33607412Targeting of tumor growth and angiogenesis underlies the enhanced antitumor activity of lenvatinib in combination with everolimus
Q53153700The Evolving Treatment Landscape of Advanced Renal Cell Carcinoma in Patients Progressing after VEGF Inhibition.
Q38579925Treatment of advanced thyroid cancer: role of molecularly targeted therapies
Q26862841Treatment strategies for radioactive iodine-refractory differentiated thyroid cancer
Q52587807Treatment-emergent hypertension and efficacy in the phase 3 Study of (E7080) lenvatinib in differentiated cancer of the thyroid (SELECT).
Q41660750Tyrosine-Kinase Inhibitors Therapies with Mainly Anti-Angiogenic Activity in Advanced Renal Cell Carcinoma: Value of PET/CT in Response Evaluation.
Q93088927Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma
Q27023383Will the Requirement by the US FDA to Simultaneously Co-Develop Companion Diagnostics (CDx) Delay the Approval of Receptor Tyrosine Kinase Inhibitors for RTK-Rearranged (ROS1-, RET-, AXL-, PDGFR-α-, NTRK1-) Non-Small Cell Lung Cancer Globally?
Q92980997Wound Dressings Based on Chitosan-Dialdehyde Cellulose Nanocrystals-Silver Nanoparticles: Mechanical Strength, Antibacterial Activity and Cytotoxicity

Search more.