Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease.

scientific article published on April 2014

Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/NAN.12066
P698PubMed publication ID23741998

P50authorFrancisco WandosellQ42702607
Juan José GarridoQ50797821
Diana SimónQ63884363
Maria Jose Benitez MorenoQ67826008
Ana I RojoQ76310820
Juan Maria TorresQ41271935
P2093author name stringA Cuadrado
M E Herva
P2860cites workCaspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithiumQ43786473
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosolQ44184136
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosolQ44184139
PrP(106-126) activates neuronal intracellular kinases and Egr1 synthesis through activation of NADPH-oxidase independently of PrPcQ46603299
Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.Q46927043
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathwayQ47762057
No propagation of prions in mice devoid of PrP.Q48101222
Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prionQ48171711
Neurotoxicity of a prion protein fragmentQ48304223
Regulation of a site-specific phosphorylation of the microtubule-associated protein 2 during the development of cultured neuronsQ48382318
De novo induction of amyloid-β deposition in vivoQ48863950
Activation of the JNK-c-Jun pathway during the early phase of neuronal apoptosis induced by PrP106-126 and prion infection.Q48873095
Microtubule-associated protein-2 located in growth regions of rat hippocampal neurons is highly phosphorylated at its proline-rich regionQ49160361
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.Q51794745
Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments.Q53214282
Caspases find a new place to hide.Q53338897
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoformsQ24300933
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinaseQ24336639
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotectionQ24534939
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418Q27641873
Molecular mechanisms of neurotoxicity of pathological prion proteinQ28280873
APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarityQ28570827
Caspases: enemies withinQ29547315
Regulation of neuronal survival by the serine-threonine protein kinase AktQ29614185
The renaissance of GSK3Q29616725
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionQ31462537
Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicalsQ31847089
Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathwayQ34278037
Synaptic pathology and cell death in the cerebellum in Creutzfeldt-Jakob diseaseQ35184541
Potential roles of insulin and IGF-1 in Alzheimer's disease.Q35192493
Insulin signaling in the central nervous system: learning to surviveQ36568898
Cellular prion protein signaling in serotonergic neuronal cellsQ36779221
The insulin/Akt signaling pathway is targeted by intracellular beta-amyloidQ37112633
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1.Q37335792
Neuroprotective and neurotoxic signaling by the prion proteinQ37877631
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.Q39962425
Resistance of cell lines to prion toxicity aided by phospho-ERK expressionQ40034009
Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cellsQ40251968
Molecular morphology and toxicity of cytoplasmic prion protein aggregates in neuronal and non-neuronal cellsQ40280647
Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activationQ40429251
The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity.Q40445820
Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.Q40576035
Prion protein fragment PrP-(106-126) induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cellsQ40782705
Neuronal cell death in scrapie-infected mice is due to apoptosisQ40979839
Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3Q41889838
Sulphated glycosaminoglycans prevent the neurotoxicity of a human prion protein fragmentQ41987801
Prion pathogenesis is independent of caspase-12.Q42068269
P433issue3
P921main subjectprion protein familyQ24724413
P304page(s)311-326
P577publication date2014-04-01
P1433published inNeuropathology and Applied NeurobiologyQ7002494
P1476titleDysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease
P478volume40