Profile of venetoclax and its potential in the context of treatment of relapsed or refractory chronic lymphocytic leukemia

scientific article published on 7 February 2017

Profile of venetoclax and its potential in the context of treatment of relapsed or refractory chronic lymphocytic leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2147/OTT.S102646
P932PMC publication ID5308588
P698PubMed publication ID28223822

P50authorStephan StilgenbauerQ47158807
P2093author name stringHenriette Huber
Sven Estenfelder
Simone Edenhofer
P2860cites workThe Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancyQ24633214
Idelalisib for the treatment of indolent non-Hodgkin lymphoma: a review of its clinical potentialQ26747753
Targeted therapies in CLL: mechanisms of resistance and strategies for managementQ27002528
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsQ27683708
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinibQ27853011
Genomic aberrations and survival in chronic lymphocytic leukemiaQ28141442
The BCL-2 protein family: opposing activities that mediate cell deathQ29547380
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activityQ33392920
Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study GroupQ33396737
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory diseaseQ33398808
Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trialQ33412064
MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignanciesQ33419789
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.Q33421292
Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 studyQ33432228
Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL.Q33794311
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignanciesQ33893704
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemiaQ34009003
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemiaQ34052075
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trialQ34141305
Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions.Q54316160
Ibrutinib inhibits collagen-mediated but not ADP-mediated platelet aggregation.Q54328623
Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting ConditionsQ56657194
Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cellsQ56901814
Involvement of the bcl-2 gene in human follicular lymphomaQ69870224
Analysis of Bcl-2 protein expression in chronic lymphocytic leukemia. A comparison of three semiquantitation techniquesQ73423141
Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cellsQ79420945
Minimal residual disease quantification is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: a multivariate analysis from the randomized GCLLSG CLL8 trialQ83441006
VSV Oncolysis in Combination With the BCL-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance in Chronic Lymphocytic LeukemiaQ34382986
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic LeukemiaQ34504188
Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab)Q34508322
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinibQ35450520
Second cancers in patients with chronic lymphocytic leukemia who received frontline fludarabine, cyclophosphamide and rituximab therapy: distribution and clinical outcomesQ35625192
Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic LeukemiaQ35903984
Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic LeukemiaQ35958056
A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiencyQ36358469
Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic LeukemiaQ36490049
Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemiaQ36597026
Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivoQ36619787
Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic LeukemiaQ36888218
Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity.Q37097096
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cellsQ37209768
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytesQ37226729
Signaling the end of chronic lymphocytic leukemia: new frontline treatment strategiesQ38142762
Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): a randomised, multicentre, open-label phase 3 trialQ38424831
Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer.Q38563530
Combination of Targeted Drugs to Control Chronic Lymphocytic Leukemia: Harnessing the Power of New Monoclonal Antibodies in Combination With IbrutinibQ38721654
Chemoimmunotherapy Versus Targeted Treatment in Chronic Lymphocytic Leukemia: When, How Long, How Much, and in Which Combination?Q38850312
Venetoclax: First Global ApprovalQ38853500
Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.Q38959765
Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma.Q38999783
Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trialQ39005118
BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphomaQ40357519
State-of-the-Art Treatment and Novel Agents in Chronic Lymphocytic LeukemiaQ40786236
Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinibQ41601558
The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 ProteinQ42383180
Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia.Q43145571
Comorbidity and functional status are independent in older cancer patientsQ44747457
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemiaQ46247309
Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemiaQ46378902
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectlymphocyteQ715347
P304page(s)645-656
P577publication date2017-02-07
P1433published inOncoTargets and TherapyQ7092081
P1476titleProfile of venetoclax and its potential in the context of treatment of relapsed or refractory chronic lymphocytic leukemia
P478volume10

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cites work (P2860)
Q55280895Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia.
Q59797087TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics