Edaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease

scientific article published on 10 May 2013

Edaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12031-013-0022-8
P698PubMed publication ID23657982

P2093author name stringBing Li
Dawei Yu
Zhiying Xu
P2860cites workNeuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neuronsQ21262040
DJ-1 has a role in antioxidative stress to prevent cell deathQ24306633
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
Edaravone guards dopamine neurons in a rotenone model for Parkinson's diseaseQ27335848
In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133Q28270649
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1Q28506681
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Q28593258
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's diseaseQ28594269
Parkinson's diseaseQ29616302
Parkinson's disease. First of two partsQ29620416
BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activityQ33689625
High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life.Q33919434
Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in womenQ34474458
Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatumQ34568490
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.Q34578581
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localizationQ34836156
A randomized controlled clinical trial to compare the safety and efficacy of edaravone in acute ischemic strokeQ35121559
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's diseaseQ35660223
Toxic proteins released from mitochondria in cell deathQ35743127
Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathwaysQ36186542
Molecular pathophysiology of Parkinson's diseaseQ36196507
L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.Q36341135
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.Q37485355
Parkinson disease: insights in clinical, genetic and pathological features of monogenic disease subtypesQ37910371
Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells.Q39249288
Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.Q39876870
DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell deathQ40007595
DJ-1 decreases Bax expression through repressing p53 transcriptional activityQ40043929
Assessment of cell viability in primary neuronal culturesQ42168073
Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicentersQ44418044
Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expressionQ44484424
Effects of edaravone on reperfusion injury in patients with acute myocardial infarctionQ45027825
The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.Q45933136
Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS miceQ46418017
Edaravone protects against MPP+ -induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathwayQ46471698
Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in ratsQ46514766
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's diseaseQ46683999
Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhageQ46838344
Parkinson disease: from pathology to molecular disease mechanismsQ48177704
Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.Q48719184
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonismQ79249169
Long-term efficacy of edaravone in patients with acute myocardial infarctionQ79786705
P433issue2
P921main subjectedaravoneQ335099
neurotoxicityQ3338704
toxic encephalopathyQ7830379
Parkinson's diseaseQ11085
P304page(s)539-549
P577publication date2013-05-10
P1433published inJournal of Molecular NeuroscienceQ15708870
P1476titleEdaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease
P478volume51

Reverse relations

cites work (P2860)
Q34412765Edaravone promotes functional recovery after mechanical peripheral nerve injury
Q36323797Edaravone protects against hyperosmolarity-induced oxidative stress and apoptosis in primary human corneal epithelial cells
Q38244581Edaravone's free radical scavenging mechanisms of neuroprotection against cerebral ischemia: review of the literature
Q88574928Elevated expression of DJ-1 (encoded by the human PARK7 gene) protects neuronal cells from sevoflurane-induced neurotoxicity
Q42416499Oxygen-glucose-deprived rat primary neural cells exhibit DJ-1 translocation into healthy mitochondria: a potent stroke therapeutic target

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