SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia.

scientific article published on 22 March 2013

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/EMBOJ.2013.65
P932PMC publication ID3671254
P698PubMed publication ID23524851
P5875ResearchGate publication ID236076653

P50authorJeremy M. HenleyQ38328313
Laura DeardenQ42059164
Kevin A WilkinsonQ59692803
P2093author name stringJia Luo
Chun Guo
Keri L Hildick
P2860cites workSUMO on the road to neurodegenerationQ36809376
Distribution and paralogue specificity of mammalian deSUMOylating enzymesQ37111042
SUMOylation participates in induction of ischemic toleranceQ37216682
Lysosomal membrane permeabilization in cell deathQ37310191
SUMOylation and De-SUMOylation: wrestling with life's processesQ37325310
Bcl-2 family on guard at the ER.Q37412841
Mitochondrial outer-membrane permeabilization and remodelling in apoptosisQ37480112
Translational control of eukaryotic gene expressionQ37551949
Protein SUMOylation in neuropathological conditions.Q37553976
Targets and consequences of protein SUMOylation in neurons.Q37728628
Inhibition of Drp1 provides neuroprotection in vitro and in vivo.Q39386090
Packaging of endogenous retroviral sequences in retroviral vectors produced by murine and human packaging cellsQ39578897
Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosisQ39697070
Transient global cerebral ischemia induces a massive increase in protein sumoylationQ40120643
Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.Q40458348
Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neuronesQ42059132
Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathwaysQ42834927
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.Q43627961
Increased protein SUMOylation following focal cerebral ischemia.Q46908369
Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fissionQ47197847
The endoplasmic reticulum and neurological diseasesQ48516383
Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.Q53548157
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.Q53571110
The SUMO protease SENP5 is required to maintain mitochondrial morphology and functionQ56907347
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugationQ80427817
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerizationQ24300125
SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell deathQ24301299
SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycleQ24318317
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylationQ24328747
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alphaQ24540258
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.Q24541469
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosisQ24562044
Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative diseaseQ26853356
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPsQ27865192
Mechanisms, regulation and consequences of protein SUMOylationQ27865251
A regulatory link between ER-associated protein degradation and the unfolded-protein responseQ27931238
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapsesQ29615239
Mitochondria and cell death: outer membrane permeabilization and beyondQ29615459
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Mitochondrial fission, fusion, and stressQ29616536
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosisQ29616568
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in miceQ29617092
Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell deathQ29620448
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell deathQ30480587
Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damageQ34053347
PDSM, a motif for phosphorylation-dependent SUMO modificationQ34248164
The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteasesQ34695640
Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3.Q34864658
SUMO2/3 conjugation is an endogenous neuroprotective mechanismQ35534157
Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosisQ35621378
Oxidative stress and neuronal death/survival signaling in cerebral ischemiaQ36161829
Role of mitochondria as the gardens of cell deathQ36263117
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashionQ36370419
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilizationQ36496658
Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cellsQ36676352
The apoptosome: signalling platform of cell deathQ36766418
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcell deathQ2383867
P304page(s)1514-1528
P577publication date2013-03-22
P1433published inThe EMBO JournalQ1278554
P1476titleSENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia
P478volume32

Reverse relations

cites work (P2860)
Q60143780Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology
Q38557970Battling Alzheimer's Disease: Targeting SUMOylation-Mediated Pathways
Q92912028CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway
Q39386692Concepts and Methodologies to Study Protein SUMOylation: An Overview.
Q35170990Cyclin C mediates stress-induced mitochondrial fission and apoptosis
Q39827142DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission
Q49911371DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages
Q64115483Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum
Q90206029Divide et Impera: Drp1-mediated Mitochondrial Fission in Glioma Malignancy
Q37631600Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals
Q57462893Effects of farnesoid-X-receptor SUMOylation mutation on myocardial ischemia/reperfusion injury in mice
Q48280468Expression and Cell Distribution of SENP3 in Brain Tissue After Traumatic Brain Injury in Mice: A Pilot Study
Q48447452Expression and cell distribution of SENP3 in the cerebral cortex after experimental subarachnoid hemorrhage in rats: a pilot study
Q39542982Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology.
Q37026526Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/glucose.
Q27316713Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells
Q59351029ISG15, a Small Molecule with Huge Implications: Regulation of Mitochondrial Homeostasis
Q39442271Inhibition of mitochondrial fission as a molecular target for cardioprotection: critical importance of the timing of treatment.
Q48187158Localization and regulation of PML bodies in the adult mouse brain.
Q97884884Mechanisms and roles of mitochondrial localisation and dynamics in neuronal function
Q41949133Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion
Q89486050Methylene Blue Protects Against Sevoflurane-Induced Cognitive Dysfunction by Suppressing Drp1 deSUMOylation in Aged Mice
Q38179990Mitochondria dynamism: of shape, transport and cell migration
Q39008813Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases
Q47993915Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy
Q46438173Mitochondrial Fission in Human Diseases
Q91942085Mitochondrial Quality Control in Cardiomyocytes: A Critical Role in the Progression of Cardiovascular Diseases
Q39116596Mitochondrial dynamics in neuronal injury, development and plasticity
Q90374857Mitochondrial dynamics: overview of molecular mechanisms
Q26738961Mitochondrial fission - a drug target for cytoprotection or cytodestruction?
Q38966173Mitochondrial fission and fusion in secondary brain damage after CNS insults
Q27013930Mitochondrial fission: regulation and ER connection
Q28084134Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease
Q38939582Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage
Q38115818Molecular targets underlying SUMO-mediated neuroprotection in brain ischemia
Q27006036Morphological control of mitochondrial bioenergetics
Q34295237Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction
Q44048230Post-translational modification: A SUMO protease for stress protection
Q56481262Protective effect of SENP3-mediated SUMOylation against cadmium toxicity
Q64056855Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury
Q47965761Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
Q38128213Receptor trafficking and the regulation of synaptic plasticity by SUMO.
Q47943084Regulation of Mitochondrial Dynamics and Autophagy by the Mitochondria-Associated Membrane
Q58784390Regulation of axon repulsion by MAX-1 SUMOylation and AP-3
Q39343356Regulation of dynamin family proteins by post-translational modifications
Q35929111Regulators of mitochondrial dynamics in cancer
Q64762196Role of GTPases in the regulation of mitochondrial dynamics in Parkinson's disease
Q92175147Roles and mechanisms of SUMOylation on key proteins in myocardial ischemia/reperfusion injury
Q38927612SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death
Q50641117SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy.
Q37297379SUMO and Alzheimer's disease
Q38115253SUMO and ischemic tolerance
Q39108925SUMO and the robustness of cancer
Q99616863SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans
Q38132691SUMO rules: regulatory concepts and their implication in neurologic functions.
Q36898510SUMO wrestling with Drp1 at mitochondria
Q38757045SUMO-regulated mitochondrial function in Parkinson's disease
Q37603287SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion
Q37419220SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease.
Q38260216SUMO-specific proteases/isopeptidases: SENPs and beyond
Q97884803SUMOylation and calcium signalling: potential roles in the brain and beyond
Q47392649SUMOylation in brain ischemia: Patterns, targets, and translational implications.
Q97516927SUMOylation in α-Synuclein Homeostasis and Pathology
Q35275798SUMOylation occurs in acute kidney injury and plays a cytoprotective role
Q47761796Significance of Mitochondrial Protein Post-translational Modifications in Pathophysiology of Brain Injury
Q28390513Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1
Q26747536Sumoylation in Synaptic Function and Dysfunction
Q47799714Sumoylation: Implications for Neurodegenerative Diseases
Q41678635Targeting the SUMO pathway for neuroprotection in brain ischaemia
Q36247924The Rice Dynamin-Related Protein OsDRP1E Negatively Regulates Programmed Cell Death by Controlling the Release of Cytochrome c from Mitochondria
Q39136006The Roles of SUMO in Metabolic Regulation
Q36192590The SUMO Protease SENP3 Orchestrates G2-M Transition and Spindle Assembly in Mouse Oocytes
Q55314869The transcription factor MEF2A plays a key role in the differentiation/maturation of rat neural stem cells into neurons.
Q34825960Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
Q35122358UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
Q52374464Understanding the Unfolded Protein Response in the Pathogenesis of Asthma.
Q38182534Wrestling with stress: roles of protein SUMOylation and deSUMOylation in cell stress response
Q92713372Zinc-Induced SUMOylation of Dynamin-Related Protein 1 Protects the Heart against Ischemia-Reperfusion Injury

Search more.