EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice

scientific article

EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI63572
P932PMC publication ID3561811
P698PubMed publication ID23281395

P2093author name stringAkira Hara
Junya Toguchida
Akira Watanabe
Hiroshi Moritake
Yasuhiro Yamada
Shunichi Shiozawa
Katsuji Shimizu
Takahiro Kunisada
Yukiko Kobayashi
Kazunari Yamada
Takatoshi Ohno
Katsunori Semi
Hitomi Aoki
P2860cites workThe EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domainsQ24319886
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusQ24797230
Fate of the mammalian cardiac neural crestQ28139176
Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogeneQ28205414
MITF: master regulator of melanocyte development and melanoma oncogeneQ28256859
The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activatorQ28272721
Cancer. Addiction to oncogenes--the Achilles heal of cancerQ29614243
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaQ29614282
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesisQ29616631
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Q29617856
c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1Q33384492
Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways augment the sensitivity to actinomycin D in Ewing sarcomaQ33407429
Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cellsQ33992270
Clear cell sarcoma: the Roswell Park experienceQ34245901
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: clear cell sarcoma (malignant melanoma of soft parts).Q34416194
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissuesQ34417194
Clear cell sarcoma (malignant melanoma) of soft parts: A clinicopathologic study of 30 casesQ34505034
Clear cell sarcoma of tendons and aponeuroses in pediatric patients: a report from the Italian and German Soft Tissue Sarcoma Cooperative GroupQ34525252
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.Q34568270
Clear cell sarcoma of tendons and aponeuroses: a study of 75 patientsQ34572878
A conditional mouse model of synovial sarcoma: insights into a myogenic originQ34578484
Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic miceQ35184753
Molecular diagnosis of clear cell sarcoma: detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 casesQ35869365
A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimerasQ35929114
EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanomaQ36042612
The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcomaQ36648458
Identification of a cyclic-AMP-responsive element within the rat somatostatin geneQ37398428
Promoters containing ATF-binding sites are de-regulated in cells that express the EWS/ATF1 oncogene.Q38295666
Synergistic increase in c-fos expression by simultaneous activation of the ras/raf/map kinase- and protein kinase A signaling pathways is mediated by the c-fos AP-1 and SRE sites.Q38339180
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive elementQ38346007
Inhibition of platelet-derived growth factor-induced cell growth signaling by a short interfering RNA for EWS-Fli1 via down-regulation of phospholipase D2 in Ewing sarcoma cells.Q40416613
Identification of target genes for EWS/ATF-1 chimeric transcription factor.Q40677580
Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.Q41461695
Osteoblasts are target cells for transformation in c-fos transgenic miceQ41537457
Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II.Q42827236
Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion geneQ42830152
Cytogenetic findings in clear cell sarcoma of tendons and aponeuroses. Malignant melanoma of soft partsQ43466194
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cellsQ46885318
Classification of clear-cell sarcoma as a subtype of melanoma by genomic profilingQ47944707
A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmissionQ48952910
Malignant melanoma of the soft parts (clear-cell sarcoma): confirmation of EWS and ATF-1 gene fusion caused by a t(12;22) translocationQ49094393
c-fos is required for malignant progression of skin tumors.Q53461261
Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.Q54714854
A cyclic AMP- and phorbol ester-inducible DNA elementQ59069805
MMSP tumor cells expressing the EWS/ATF1 oncogene do not support cAMP-inducible transcriptionQ64382115
Chromosomal abnormalities in clear cell sarcoma. Implications for histogenesisQ68691630
Clear-cell sarcoma of tendons and aponeuroses. An immunohistochemical and electron microscopic analysis indicating neural crest originQ70446770
Clear cell sarcoma. A clinicopathologic study of 27 casesQ71029921
Clear cell sarcoma shows immunoreactivity for microphthalmia transcription factor: further evidence for melanocytic differentiationQ73519767
The DNA binding domains of the WT1 tumor suppressor gene product and chimeric EWS/WT1 oncoprotein are functionally distinctQ74371582
The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directlyQ74502742
A novel transgenic technique that allows specific marking of the neural crest cell lineage in miceQ78038712
CLEAR-CELL SARCOMA OF TENDONS AND APONEUROSES. AN ANALYSIS OF 21 CASESQ78506577
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)600-610
P577publication date2013-01-02
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleEWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice
P478volume123

Reverse relations

cites work (P2860)
Q48009686Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
Q38784600An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development
Q58569719An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva
Q35862728Biologic Activity of Autologous, Granulocyte-Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines
Q64946044CD151 confers metastatic potential to clear cell sarcoma of the soft tissue in animal model.
Q93133457Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas
Q33798299Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model
Q92131504Current Approaches for Personalized Therapy of Soft Tissue Sarcomas
Q37549595Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application.
Q28550973SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier
Q92780387Systematic Functional Interrogation of Genes in GWAS Loci Identified ATF1 as a Key Driver in Colorectal Cancer Modulated by a Promoter-Enhancer Interaction
Q41712411Trabectedin is a promising antitumor agent potentially inducing melanocytic differentiation for clear cell sarcoma

Search more.