Hyaluronic acid: A key molecule in skin aging

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Hyaluronic acid: A key molecule in skin aging is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/DERM.21923
P932PMC publication ID3583886
P698PubMed publication ID23467280
P5875ResearchGate publication ID235881384

P50authorMichael RothQ38329018
P2093author name stringGeorge Karakiulakis
Eleni Papakonstantinou
P2860cites workTissue structure-specific distribution of glycosaminoglycans in the human penisQ73205189
Isolation of oligosaccharides enzymatically produced from hyaluronic acidQ73534931
A microtiter-based assay for hyaluronidase activity not requiring specialized reagentsQ73702186
Understanding premature skin agingQ73848807
Oligosaccharides of hyaluronan are potent activators of dendritic cellsQ74108237
Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivoQ74199057
Irradiation-induced expression of hyaluronan (HA) synthase 2 and hyaluronidase 2 genes in rat lung tissue accompanies active turnover of HA and induction of types I and III collagen gene expressionQ74259168
The production of capsules, hyaluronic acid and hyaluronidase by 25 strains of group C streptococciQ74331535
CD44 variant isoforms are essential for the function of epidermal Langerhans cells and dendritic cellsQ77583512
Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophagesQ77696816
Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44Q79815582
Increased hyaluronic acid content in idiopathic pulmonary arterial hypertensionQ81924633
Differential hyaluronan homeostasis and expression of proteoglycans in juvenile and adult human skinQ82506138
Steroids and β2-agonists regulate hyaluronan metabolism in asthmatic airway smooth muscle cellsQ84735243
Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expressionQ36366507
TGF-beta 1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronanQ36383241
Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammationQ36403514
Hyaluronidases: their genomics, structures, and mechanisms of actionQ36415698
Degradative action of reactive oxygen species on hyaluronan.Q36418010
The role of Toll-like receptors in non-infectious lung injuryQ36559267
Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathwaysQ36630402
Skin ageing and its treatmentQ36698245
Chronic sun exposure alters both the content and distribution of dermal glycosaminoglycansQ36828297
How best to halt and/or revert UV-induced skin ageing: strategies, facts and fiction.Q37080163
The role of hyaluronan synthase 3 in ventilator-induced lung injury.Q37282731
The 'sweet' and 'bitter' involvement of glycosaminoglycans in lung diseases: pharmacotherapeutic relevanceQ37346515
Androgens and ageing of the skinQ37457942
Immunological functions of hyaluronan and its receptors in the lymphaticsQ37548667
The role of a cell-associated hyaluronan-binding protein in fibroblast behaviour.Q38208341
Hyaluronan oligosaccharides as a potential anticancer therapeuticQ38288397
Identification of two hyaluronan-binding domains in the hyaluronan receptor RHAMMQ38319979
Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responsesQ38363542
Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitroQ38518171
Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44.Q39774105
Hyaluronan‐binding proteins in development, tissue homeostasis, and diseaseQ40490752
Keratinocyte Growth Factor Stimulates Migration and Hyaluronan Synthesis in the Epidermis by Activation of Keratinocyte Hyaluronan Synthases 2 and 3Q40631967
Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cellsQ40637915
Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronanQ40819212
Hyaluronan induces monocyte chemoattractant protein-1 expression in renal tubular epithelial cells.Q40989195
THE HYALURONIC ACID OF SYNOVIAL FLUID IN RHEUMATOID ARTHRITIS.Q40999250
Tumor-associated hyaluronan. Providing an extracellular matrix that facilitates invasion.Q41008414
Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanismQ41120284
Hyaluronic acid is a major component of the matrix of fetal rabbit skin and wounds: implications for healing by regenerationQ41184312
A review of skin ageing and its medical therapyQ41285306
Characterization and quantitation of wound matrix in the fetal rabbitQ41323741
Hyaluronan on the surface of tumor cells is correlated with metastatic behavior.Q41380712
Hyaluronan synthasesQ41517952
Hyaluronan in skinQ41566303
Release of hyaluronate from eukaryotic cellsQ41738868
Plasma clearance, tissue distribution and metabolism of hyaluronic acid injected intravenously in the rabbitQ41999347
Assay of serum hyaluronic acid in clinical applicationQ42002707
Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cellsQ42425847
Distribution of hyaluronan and its CD44 receptor in the epithelia of human skin appendagesQ42456456
Hyaluronate is synthesized at plasma membranesQ42868509
Hypoxia differentially enhances the effects of transforming growth factor-beta isoforms on the synthesis and secretion of glycosaminoglycans by human lung fibroblastsQ44002276
Relationship between lymph and tissue hyaluronan in skin and skeletal muscleQ44185628
Differential effect of transforming growth factor beta (TGF-beta) on the genes encoding hyaluronan synthases and utilization of the p38 MAPK pathway in TGF-beta-induced hyaluronan synthase 1 activationQ44693918
Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblastsQ44756854
Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.Q44781757
Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes.Q45929429
HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificityQ24336192
Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluidQ24540430
Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cellsQ28140125
Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motilityQ28187168
Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformationQ28288172
Clinical and biochemical manifestations of hyaluronidase deficiencyQ28288980
Molecular identification of a putative human hyaluronan synthaseQ28289227
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic propertiesQ28585737
Hyaluronan and its binding proteins, the hyaladherinsQ28610932
Platelet-derived growth factor stimulates the secretion of hyaluronic acid by proliferating human vascular smooth muscle cellsQ33876874
Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migrationQ34019316
Hyaluronan: a multifunctional, megaDalton, stealth moleculeQ34026287
Hyaluronate in normal human synovial fluidQ34093839
The six hyaluronidase-like genes in the human and mouse genomesQ34103842
Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probeQ34402741
Regulation of lung injury and repair by Toll-like receptors and hyaluronanQ34462186
Hyaluronan and its catabolic products in tissue injury and repairQ34517570
Mechanisms of photoaging and chronological skin agingQ34529107
Hyaluronan as an immune regulator in human diseases.Q34636380
Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to ultraviolet B (UVB): new insights into mechanisms of matrix remodelingQ34979131
Mammalian hyaluronan synthasesQ35038976
Hyaluronan in Respiratory Injury and RepairQ35114619
Hyaluronan and cell locomotionQ35333946
Hyaluronan: from extracellular glue to pericellular cue.Q35824079
Hyaluronan and CD44: modulators of chondrocyte metabolism.Q35916113
Hyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcinoma transitionsQ36155022
Light and electron microscopic studies on the localization of hyaluronic acid in developing rat cerebellumQ36218783
An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell functionQ36262039
Hyaluronidases--a group of neglected enzymesQ36279394
Hyaluronan forms specific stable tertiary structures in aqueous solution: a 13C NMR studyQ36332235
Differential glycosaminoglycan expression and hyaluronan homeostasis in juvenile hyaline fibromatosis.Q45950421
Hyaluronan in skin: aspects of aging and its pharmacologic modulationQ46041306
Decreased hyaluronan in airway smooth muscle cells from patients with asthma and COPD.Q46090444
Age-dependent changes of hyaluronan in human skinQ46163462
Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injuryQ46457465
Benign hyperplasia of the human prostate is associated with tissue enrichment in chondroitin sulphate of wide size distributionQ47235383
Photodegradation of hyaluronic acid: EPR and size exclusion chromatography study.Q47423526
A 340 kDa hyaluronic acid secreted by human vascular smooth muscle cells regulates their proliferation and migrationQ47929146
Changes in glycosaminoglycans and related proteoglycans in intrinsically aged human skin in vivoQ50279701
A substrate-gel assay for hyaluronidase activityQ50788818
Angiogenesis induced by degradation products of hyaluronic acid.Q55057424
Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility [published erratum appears in J Cell Biol 1992 Aug;118(3):753]Q55952135
Biosynthesis of HyaluronateQ59022915
Catabolism of hyaluronan in rabbit skin takes place locally, in lymph nodes and liverQ67759299
Hyaluronan in the rat with special reference to the skinQ68034835
Removal rate of [3H]hyaluronan injected subcutaneously in rabbitsQ68887157
A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healingQ69575287
Evidence for structural changes in dermatan sulfate and hyaluronic acid with agingQ69782405
Effect of oxygen-derived reactive species on cartilage proteoglycan-hyaluronate aggregatesQ70815560
The distribution of hyaluronan in human skin and mature, hypertrophic and keloid scarsQ71655231
Induction of hyaluronan metabolism after mechanical injury of human peritoneal mesothelial cells in vitroQ73108187
P433issue3
P304page(s)253-258
P577publication date2012-07-01
P1433published inDermato-endocrinologyQ26842418
P1476titleHyaluronic acid: A key molecule in skin aging
P478volume4

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cites work (P2860)
Q51111996A High Performance Impedance-based Platform for Evaporation Rate Detection.
Q51509057A novel evaporation detection system using an impedance sensing chip.
Q47611952Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts
Q34000514Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts
Q55429009An Effective Translation: The Development of Hyaluronan-Based Medical Products From the Physicochemical, and Preclinical Aspects.
Q93081187An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery
Q64095634Anti-Wrinkling and Anti-Melanogenic Effect of Methanol Extract
Q35211690Anti-aging and filling efficacy of six types hyaluronic acid based dermo-cosmetic treatment: double blind, randomized clinical trial of efficacy and safety
Q36212301Anti-aging and tyrosinase inhibition effects of Cassia fistula flower butanolic extract
Q55428518Antimelanogenesis and skin-protective activities of Panax ginseng calyx ethanol extract.
Q64902359Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract.
Q64081861Antiphotoaging and Antimelanogenic Effects of Pursh Ethanol Extract due to Antioxidant- and Autophagy-Inducing Properties
Q49362954Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair.
Q40310168Cell and Tissue Imaging with Molecularly Imprinted Polymers.
Q41897281Charged Triazole Cross-Linkers for Hyaluronan-Based Hybrid Hydrogels
Q89978369Chemical Compositions and Anti-Skin-Ageing Activities of Origanum vulgare L. Essential Oil from Tropical and Mediterranean Region
Q91844983Commercial hydrogels for biomedical applications
Q51134910Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties.
Q91809118Dietary Suberic Acid Protects Against UVB-Induced Skin Photoaging in Hairless Mice
Q64262881Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment
Q47328392Effect of Orally Administered Collagen Peptides from Bovine Bone on Skin Aging in Chronologically Aged Mice
Q90147021Effect of red ginseng NaturalGEL on skin aging
Q90360769Effectiveness of topical silicone gel and pressure garment therapy for burn scar prevention and management in children: a randomized controlled trial
Q46222420Gallic acid regulates skin photoaging in UVB-exposed fibroblast and hairless mice.
Q36159211Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation
Q34233997Hyaluronan-phosphatidylethanolamine polymers form pericellular coats on keratinocytes and promote basal keratinocyte proliferation
Q33777572Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients
Q90462072Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice
Q42776371IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation.
Q93015669Impaired Neovascularization in Aging
Q92051055In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function
Q90105858In vitro and in vivo evaluation of a moisture treatment cream containing three critical elements of natural skin moisturization
Q58759017In vitro study of RRS® Silisorg CE Class III medical device composed of silanol: effect on human skin fibroblasts and its clinical use
Q41071271Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae.
Q89597890Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro
Q51359147Morphologic Changes in the Dermis After the Single Administration of Autologous Fibroblastic Cells: A Preliminary Study.
Q48191226Noninvasive penetration of 5 nm hyaluronic acid molecules across the epidermal barrier (in vitro) and its interaction with human skin cells.
Q30490300Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing
Q47750192Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents
Q38657864Optimizing the Bioavailability of Subcutaneously Administered Biotherapeutics Through Mechanochemical Drivers
Q64901952Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
Q53190788Photoprotective effects of galacto-oligosaccharide and/or Bifidobacterium longum supplementation against skin damage induced by ultraviolet irradiation in hairless mice.
Q91814833Potential Use of Seaweed Bioactive Compounds in Skincare-A Review
Q92859142Protein-mediated gelation and nano-scale assembly of unfunctionalized hyaluronic acid and chondroitin sulfate
Q64094211Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being
Q41125229Regression of melasma with platelet-rich plasma treatment
Q50116204Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy
Q89519884Skin Hydration Effects of Scale-Up Fermented Cyclopia intermedia against Ultraviolet B-Induced Damage in Keratinocyte Cells and Hairless Mice
Q48278581Skin Protective Effect of Epigallocatechin Gallate
Q35097416Specific sizes of hyaluronan oligosaccharides stimulate fibroblast migration and excisional wound repair
Q58765773Standardized in vitro analysis of the degradability of hyaluronic acid fillers by hyaluronidase
Q38810086Stimuli-Sensitive Injectable Hydrogels Based on Polysaccharides and Their Biomedical Applications
Q38693908Sujiaonori-Derived Algal Biomaterials Inhibit Allergic Reaction in Allergen-Sensitized RBL-2H3 Cell Line and Improve Skin Health in Humans
Q41443764The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Q42229100The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder
Q38466771The Role of CD44 in Disease Pathophysiology and Targeted Treatment.
Q41584171The Roles of Vitamin C in Skin Health
Q64082778The material properties of naked mole-rat hyaluronan
Q59336758The poly-omics of ageing through individual-based metabolic modelling
Q55420481This month's guideline: The Use of Hyaluronidase in Aesthetic Practice (v2.4).
Q41528785Vetiver Essential Oil in Cosmetics: What Is New?
Q30369987Water-soluble egg membrane enhances the immunoactivating properties of an Aloe vera-based extract of Nerium oleander leaves.
Q50162741Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation
Q45072584Xanthophylls lutein and zeaxanthin modify gene expression and induce synthesis of hyaluronan in keratinocyte model of human skin
Q51031884miR-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.
Q64889102α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts.

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