Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors

scientific article

Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CMDC.201200272
P8608Fatcat IDrelease_4a7l7k5nz5dcbgwfztbt6jzzu4
P698PubMed publication ID22865828
P5875ResearchGate publication ID230620806

P50authorValérie CapraQ41118843
Angelo SalaQ41118865
Loretta LazzaratoQ42417791
Roberta FrutteroQ42417799
Barbara RolandoQ57224478
Massimo BertinariaQ60042121
G.Enrico RovatiQ64711258
Malvina HoxhaQ86833539
Clara CenaQ117276953
Mohammed Abrar Abdul Gaffar ShaikhQ117276961
Carola BuccellatiQ117276962
P2093author name stringAlberto Gasco
P2860cites workNovel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing propertiesQ39459414
Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparationsQ39929202
Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.Q40978901
Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterizationQ43057500
Dual COXIB/TP antagonists: a possible new twist in NSAID pharmacology and cardiovascular riskQ43179593
Development and biological evaluation of a novel aurora A kinase inhibitorQ44055272
Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling.Q44960382
Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trialQ57278179
NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator PropertiesQ59545648
THE AGGREGATION OF BLOOD PLATELETSQ76530970
Ligand-binding studies: old beliefs and new strategiesQ77455953
Severe acute liver injury associated with lumiracoxibQ82810248
Rofecoxib analogues possessing a nitric oxide donor sulfohydroxamic acid (SO2NHOH) cyclooxygenase-2 pharmacophore: synthesis, molecular modeling, and biological evaluation as anti-inflammatory agentsQ85077313
Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trialsQ24546221
Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysisQ24601392
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385Q27641853
Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazolesQ28168230
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2Q28194441
Assessment and prevention of gastrointestinal toxicity of non-steroidal anti-inflammatory drugsQ28200644
LIGAND: A versatile computerized approach for characterization of ligand-binding systemsQ29547346
Cyclooxygenases: structural, cellular, and molecular biologyQ29616510
Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs.Q33178529
Selective inhibitors of cyclooxygenase-2 (COX-2).Q33922865
Bioisosterism: A Rational Approach in Drug DesignQ34114437
International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progressQ34200165
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunitiesQ34245387
Coxibs and cardiovascular diseaseQ34356732
Nutritionally essential fatty acids and biologically indispensable cyclooxygenasesQ34729733
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2Q34803113
Distinct functions of COX-1 and COX-2.Q34997943
First and second generations of COX-2 selective inhibitorsQ35848204
Adverse cardiovascular effects of the coxibsQ36084983
Cyclooxygenase inhibition and cardiovascular riskQ36215336
Designed multiple ligands. An emerging drug discovery paradigmQ36284452
Antagonism of thromboxane receptors by diclofenac and lumiracoxibQ36358638
Structural and functional basis of cyclooxygenase inhibitionQ36752887
COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugsQ37061134
Current status of COX-2 inhibitorsQ37066819
Rescue strategies against non-steroidal anti-inflammatory drug-induced gastroduodenal damageQ37580036
Nitric oxide: a guardian for vascular grafts?Q37887771
Superactive mutants of thromboxane prostanoid receptor: functional and computational analysis of an active form alternative to constitutively active mutantsQ38344953
Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damageQ38612976
Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonistsQ38647071
P433issue9
P304page(s)1647-1660
P577publication date2012-08-02
P1433published inChemMedChemQ2962252
P1476titleDesigning multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors
P478volume7

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cites work (P2860)
Q38135433Inhibitors of the arachidonic acid cascade: interfering with multiple pathways
Q87877860Molecular docking, molecular modeling, and molecular dynamics studies of azaisoflavone as dual COX-2 inhibitors and TP receptor antagonists
Q94915326Polysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with a Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema
Q38504675Prostanoids and NSAIDs in cardiovascular biology and disease
Q38260626Recent developments in chimeric NSAIDs as safer anti-inflammatory agents.
Q40122116Synthesis, Spectral Analysis, In Vitro Microbiological Evaluation, and Molecular Docking Studies of Some Novel 1-(1-Aryl-1H-tetrazol-5-yl)-2-(piperidin-1-yl)ethanone Derivatives

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