A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening

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A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M115.710731
P932PMC publication ID4861426
P698PubMed publication ID26872970

P50authorPei-Yong ShiQ59435668
Siew Pheng LimQ57286090
P2093author name stringChristian G Noble
Timothy E Benson
Cheah Chen Seh
S Kirk Wright
Paul W Smith
Shahul Nilar
Fumiaki Yokokawa
Rishi Arora
P2860cites workThe global distribution and burden of dengueQ24628768
A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylationQ24672668
A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replicationQ27321114
Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom ResolutionQ27480349
1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C VirusQ27490956
Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5Q27643756
Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an InhibitorQ27676371
A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation ActivitiesQ27679917
RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation stateQ27680728
Viral replication. Structural basis for RNA replication by the hepatitis C virus polymeraseQ27697984
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A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-dependent RNA polymeraseQ33789790
Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trialsQ34431491
Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaignQ35274810
The pathogenesis of dengueQ37904027
Flavivirus RNA methylationQ38184248
Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug developmentQ38190336
The dengue virus NS5 protein as a target for drug discoveryQ38442511
Inhibition of dengue virus polymerase by blocking of the RNA tunnelQ39306357
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectDengue virusQ476209
dengue virus protein NS5Q114698643
P304page(s)8541-8548
P577publication date2016-02-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleA Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
P478volume291