The Delta Opioid Receptor in Pain Control.

scientific article

The Delta Opioid Receptor in Pain Control. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1007/164_2017_32
P698PubMed publication ID28510066

P50authorLouis GendronQ42564121
P2093author name stringKhaled Abdallah
P2860cites workStructure of the human κ-opioid receptor in complex with JDTicQ24308048
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptorQ24311708
Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignmentQ24318653
Identification of a novel family of G protein-coupled receptor associated sorting proteinsQ24336955
Dynorphin-(1-13), an extraordinarily potent opioid peptideQ24561638
Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glandsQ24561925
The evolution of vertebrate opioid receptorsQ24627645
Behavioral, medical imaging and histopathological features of a new rat model of bone cancer painQ27317157
Crystal structure of the µ-opioid receptor bound to a morphinan antagonistQ27678133
Structure of the δ-opioid receptor bound to naltrindoleQ27679153
Molecular control of δ-opioid receptor signallingQ27681274
Cloning of a delta opioid receptor by functional expressionQ28213132
Modulation of postendocytic sorting of G protein-coupled receptorsQ28216085
Chromosomal localization of the delta opioid receptor gene to human 1p34.3-p36.1 and mouse 4D bands by in situ hybridizationQ28244218
A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80Q28255208
A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled ...Q28285048
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implicationsQ28287619
Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859)Q28293705
Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based studyQ28294827
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptorsQ28366271
Cloning and pharmacological characterization of a rat kappa opioid receptorQ28378330
Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonismQ28488120
Primary afferent tachykinins are required to experience moderate to intense painQ28506575
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responsesQ28510086
Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptorsQ28582515
The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterizationQ30800519
Opioids in pain managementQ33678609
Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal hornQ33811673
Nerve growth factor-regulated emergence of functional delta-opioid receptorsQ33832271
Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neuronsQ33907117
Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.Q34059144
Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawalQ34104454
Peripheral G protein-coupled inwardly rectifying potassium channels are involved in δ-opioid receptor-mediated anti-hyperalgesia in rat masseter muscle.Q34127330
Identification of two related pentapeptides from the brain with potent opiate agonist activityQ34134593
Structure and regulation of opioid receptorsQ34136307
Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in miceQ34155247
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand seriesQ34244966
Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activityQ34354902
beta-endorphin is a potent analgesic agentQ34394408
Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.Q34424009
Peripheral opioid analgesia.Q34442053
Acute Migraine Treatment in AdultsQ34471863
Exploring the opioid system by gene knockoutQ34641459
Excessive acute migraine medication use and migraine progressionQ34887527
Peripheral mechanisms of opioid analgesiaQ34926296
Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilitiesQ34939624
Recent advances on the δ opioid receptor: from trafficking to functionQ34939664
Dissociation of the opioid receptor mechanisms that control mechanical and heat painQ34986633
Origin of pain in migraine: evidence for peripheral sensitisationQ34987743
Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor traffickingQ34989880
Postnatal development of delta-opioid receptor subtypes in miceQ35025861
Historical review: Opioid receptorsQ35111648
Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female ratsQ35165222
Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizuresQ35243440
Opioid receptors and cardioprotection - 'opioidergic conditioning' of the heartQ35286353
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory painQ35327954
The delta opioid receptor: an evolving target for the treatment of brain disordersQ35400738
Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesiclesQ35469264
Inflammatory pain is enhanced in delta opioid receptor-knockout miceQ35653788
Reward processing by the opioid system in the brain.Q35786247
Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCRQ36004099
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesiaQ36372689
Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonistQ36382976
Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approachesQ36438816
Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and toleranceQ36470261
Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channelsQ44348602
Delta-opioid receptor-immunoreactive neurons in the rat cranial sensory gangliaQ44348828
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesiaQ44349361
Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesiaQ44350199
The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsionsQ44350702
Effects of the local administration of selective mu-, delta-and kappa-opioid receptor agonists on osteosarcoma-induced hyperalgesiaQ44350955
Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout miceQ44351559
Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia.Q44351651
Neuropathic pain is enhanced in delta-opioid receptor knockout miceQ44351896
The peripheral administration of a nitric oxide donor potentiates the local antinociceptive effects of a DOR agonist during chronic inflammatory pain in mice.Q45918209
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphineQ48283682
Enkephalinergic afferents of the centromedial amygdala in the rat.Q48574704
Antinociceptive potencies of β-casomorphin analogs as compared to their affinities towards μ and δ opiate receptor sites in brain and peripheryQ48906923
Microinjection of opiates into the periaqueductal gray matter attenuates neuropathic pain symptoms in rats.Q51397850
Morphine priming in rats with chronic inflammation reveals a dichotomy between antihyperalgesic and antinociceptive properties of deltorphin.Q54575252
Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.Q55063215
mu opiate receptor: cDNA cloning and expressionQ36641338
Opioid receptors: distinct roles in mood disordersQ36675341
Cloning and expression of a cDNA for the rat kappa-opioid receptorQ36741807
Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channelsQ36753640
Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodentsQ37056129
Molecular Pharmacology of δ-Opioid ReceptorsQ37062556
Delta opioid receptors in brain function and diseasesQ37179419
GRK2 Constitutively Governs Peripheral Delta Opioid Receptor ActivityQ37239111
Opioid receptors: from binding sites to visible molecules in vivoQ37249017
Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p releaseQ37252030
Spinal activation of delta opioid receptors alleviates cancer-related bone painQ37360319
Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuliQ37360341
Characterization of a novel model of chronic migraineQ37576753
Sorting of neuropeptides and neuropeptide receptors into secretory pathwaysQ37620744
Transcriptional and epigenetic regulation of opioid receptor genes: present and futureQ37792084
Extending pharmacological spectrum of opioids beyond analgesia: multifunctional aspects in different pathophysiological statesQ37826255
Cortical spreading depression and migraineQ38138398
Discrete mapping of brain Mu and delta opioid receptors using selective peptides: quantitative autoradiography, species differences and comparison with kappa receptorsQ38344737
Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide.Q38350445
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic painQ38395503
Eluxadoline: First Global ApprovalQ38543345
What can we learn about rheumatoid arthritis from animal models?Q38760986
Delta-opioid receptors as targets for migraine therapyQ38792542
Drug Interaction and Serotonin Toxicity with Opioid Use: Another Reason to Avoid Opioids in Headache and Migraine TreatmentQ38908375
Analgesia targeting IB4-positive neurons in cancer-induced mechanical hypersensitivityQ39249576
Selective delta opioid receptor agonists for inflammatory and neuropathic painQ39419113
The analgesic efficacy of intrathecal D-Ala2-D-Leu5-enkephalin in cancer patients with chronic painQ39546846
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor HeteromersQ39738929
Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance.Q39871479
Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.Q39959986
A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypesQ40446034
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimersQ40551758
Orphanin FQ/nociceptin: a role in pain and analgesia, but so much moreQ40857019
Opioid receptor types and subtypes: the delta receptor as a model.Q41048199
Type-specific sorting of G protein-coupled receptors after endocytosisQ41728938
Increased abundance of opioid receptor heteromers after chronic morphine administrationQ42081407
Coexpression of alpha 2A-adrenergic and delta-opioid receptors in substance P-containing terminals in rat dorsal hornQ42177229
Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord.Q42463227
Prolonged morphine treatment selectively increases membrane recruitment of delta-opioid receptors in mouse basal gangliaQ42476246
Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).Q42717480
Endogenous opioids: overview and current issuesQ43070748
Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligandsQ43120295
Antihyperalgesic effects of delta opioid agonists in a rat model of chronic inflammationQ43263736
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).Q43289095
Anatomical evidence for presynaptic modulation by the delta opioid receptor in the ventrolateral periaqueductal gray of the rat.Q43514532
The role of delta-opioid receptor subtypes in neuropathic painQ43540650
Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligandQ43737770
Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley ratsQ44174860
Opioid receptor-induced GTPgamma35S binding during mouse developmentQ44254666
Cancer-related bone pain is attenuated by a systemically available delta-opioid receptor agonistQ44329855
Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient miceQ44330126
Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout miceQ44330314
Chronic morphine administration results in tolerance to delta opioid receptor-mediated antinociceptionQ44330555
Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slicesQ44330617
Anti-allodynic effects of peripheral delta opioid receptors in neuropathic painQ44331988
Electron microscopic localization of photoaffinity-labelled delta opioid receptors in the neostriatum of the ratQ44332255
Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root gangliaQ44333074
Spinal administration of a delta opioid receptor agonist attenuates hyperalgesia and allodynia in a rat model of neuropathic painQ44333270
Equal proportions of small and large DRG neurons express opioid receptor mRNAsQ44334243
Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanismsQ44335160
Distinct distributions of mu, delta and kappa opioid receptor mRNA in rat brainQ44335378
Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medullaQ44336043
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization studyQ44336066
Immunohistochemical distribution of delta opioid receptors in the rat central nervous system: evidence for somatodendritic labeling and antigen-specific cellular compartmentalizationQ44337234
Delta opioid receptor mRNA distribution in the brain: comparison to delta receptor binding and proenkephalin mRNA.Q44338426
Localization of the kappa opioid receptor gene to human chromosome band 8q11.2.Q44338675
Up-regulation and trafficking of delta opioid receptor in a model of chronic inflammation: implications for pain controlQ44340167
Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory painQ44341214
Translocation of presynaptic delta opioid receptors in the ventrolateral periaqueductal gray after swim stress.Q44342444
Phylogenetic changes in the expression of delta opioid receptors in spinal cord and dorsal root gangliaQ44342783
Evidence for a selective role of the delta-opioid agonist [8R-(4bS*,8aalpha,8abeta, 12bbeta)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline hydrochloride (SBQ44343055
Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat.Q44344453
Supraspinal delta 1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic miceQ44345360
The role of spinal delta1-opioid receptors in inhibiting the formalin-induced nociceptive response in diabetic miceQ44345943
Ontogenesis of delta-opioid receptors in rat brain using [3H][D-Pen2,D-Pen5]enkephalin as a binding ligandQ44347450
Comparison between delta-opioid receptor functional response and autoradiographic labeling in rat brain and spinal cordQ44347541
Dual ultrastructural immunocytochemical labeling of mu and delta opioid receptors in the superficial layers of the rat cervical spinal cordQ44347864
Localization and regulation of the delta-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: evidence for association with the membrane of large dense-core vesiclesQ44347921
Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout miceQ44348234
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment.Q44348492
P921main subjectopioidQ427523
P304page(s)147-177
P577publication date2018-01-01
P1433published inHandbook of experimental pharmacologyQ26841924
P1476titleThe Delta Opioid Receptor in Pain Control
P478volume247

Reverse relations

cites work (P2860)
Q95660672Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies
Q43075742Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.
Q51744085Dual immuno-renal targeting of 7-benzylidenenaltrexone alleviates lupus nephritis via FcγRIIB and HO-1.
Q90061419From Pleasure to Pain, and Back Again: The Intricate Relationship Between Alcohol and Nociception

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