Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition.

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Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1004203792
P356DOI10.1186/1756-6606-3-6
P932PMC publication ID2829547
P698PubMed publication ID20181083
P5875ResearchGate publication ID41561385

P50authorGerald W. ZamponiQ41835777
P2093author name stringLina Chen
Diego Varela
Alexandra E Kisilevsky
Hugo W Tedford
Lucienne B Vieira
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Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neuronesQ28581623
Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G protein subunit isoformsQ28582330
Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunitsQ34380635
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Targeting Ca2+ channels to treat pain: T-type versus N-type.Q35960328
Decay of prepulse facilitation of N type calcium channels during G protein inhibition is consistent with binding of a single Gbeta subunitQ36017274
Direct G protein modulation of Cav2 calcium channels.Q36667410
Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channelsQ37199748
Intracellular Ca2+ buffers disrupt muscarinic suppression of Ca2+ current and M current in rat sympathetic neurons.Q37379683
G-proteins modulate cumulative inactivation of N-type (Cav2.2) calcium channels.Q40191552
Modulation of ion-channel function by G-protein-coupled receptorsQ40397855
Calcium channel beta subunits differentially regulate the inhibition of N-type channels by individual Gbeta isoformsQ40780100
Identification of an integration center for cross-talk between protein kinase C and G protein modulation of N-type calcium channelsQ40970956
Crosstalk between G proteins and protein kinase C mediated by the calcium channel alpha1 subunit.Q41132629
Modulation of Ca2+ channels by G-protein beta gamma subunitsQ41214714
Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependenceQ41276531
Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain.Q41858723
Functional role of a C-terminal Gbetagamma-binding domain of Ca(v)2.2 channelsQ42466438
Prostaglandin modulation of Ca2+ channels in rat sympathetic neurones is mediated by guanine nucleotide binding proteins.Q45969969
Biochemical properties and subcellular distribution of an N-type calcium channel alpha 1 subunitQ46143207
Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice.Q46612900
Modulation of voltage-dependent calcium channels by G proteinsQ47754115
GABAB receptor inhibition of P-type Ca2+ channels in central neuronsQ48293724
Identification of residues in the N terminus of alpha1B critical for inhibition of the voltage-dependent calcium channel by Gbeta gamma.Q48911539
Kinetic basis for the voltage-dependent inhibition of N-type calcium current by somatostatin and norepinephrine in chick sympathetic neurons.Q51658096
Adenosine modulates voltage-gated Ca2+ channels in adult rat sympathetic neurons.Q54233828
α-Adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gatingQ59005805
Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neuronsQ60199531
Somatostatin blocks a calcium current in rat sympathetic ganglion neuronesQ69115007
Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channelsQ71511381
Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathwavsQ72068927
Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neuronesQ72510114
The intracellular loop between domains I and II of the B-type calcium channel confers aspects of G-protein sensitivity to the E-type calcium channelQ73009446
P304page(s)6
P577publication date2010-02-03
P1433published inMolecular BrainQ6895938
P1476titleScanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition
P478volume3

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cites work (P2860)
Q38861018A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.
Q36159142Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels
Q34639816G protein modulation of CaV2 voltage-gated calcium channels
Q43612129Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca²+ channel peptides
Q36318896Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides
Q38087443Omega-conotoxins as experimental tools and therapeutics in pain management
Q36565441Regulation of Ca(V)2 calcium channels by G protein coupled receptors.
Q30155988The β Subunit of Voltage-Gated Ca2+Channels

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