Agonist potency at P2X7 receptors is modulated by structurally diverse lipids

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Agonist potency at P2X7 receptors is modulated by structurally diverse lipids is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0707417
P932PMC publication ID2050815
P698PubMed publication ID17700717
P5875ResearchGate publication ID6138469

P2093author name stringA D Michel
E Fonfria
P2860cites workHuman TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptorsQ22254402
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptorQ24306745
Proteomic and functional evidence for a P2X7 receptor signalling complexQ24535912
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Blockade of human P2X7 receptor function with a monoclonal antibodyQ77531722
RetractionQ28302699
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)Q28568856
RETRACTED: Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.Q34085160
Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1Q34162004
Receptors for protons or lipid messengers or both?Q34583409
Sphingosylphosphorylcholine-biological functions and mechanisms of actionQ34691524
ATP, a partial agonist for the P2Z receptor of human lymphocytesQ35026800
Membrane targeted anticancer drugs: potent inducers of apoptosis and putative radiosensitisersQ35181155
Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosisQ36348728
Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule.Q36357782
P2 receptors and cancerQ36418844
Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayersQ36435393
Miltefosine: oral treatment of leishmaniasisQ36441483
Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardiumQ37031335
Lysophosphatidylcholine potentiates Ca2+ influx, pore formation and p44/42 MAP kinase phosphorylation mediated by P2X7 receptor activation in mouse microglial cellsQ40145211
Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7 receptor-independent mechanismQ40201601
GABA(A) receptor function is regulated by lipid bilayer elasticityQ40216662
Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptorsQ40314793
Sensing of lysophospholipids by TRPC5 calcium channelQ40337792
Pharmacological and biophysical properties of the human P2X5 receptorQ40645853
Rapid secretion of interleukin-1beta by microvesicle sheddingQ40765816
Apparent species differences in the kinetic properties of P2X(7) receptorsQ40883984
Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells.Q40925478
Pore dilation of neuronal P2X receptor channelsQ40960421
Properties of the pore-forming P2X7 purinoceptor in mouse NTW8 microglial cellsQ41097625
Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of bindingQ41556777
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.Q41646184
Direct activation of Ca2+ channels by palmitoyl carnitine, a putative endogenous ligandQ41788033
Effects of lysophosphatidylcholine on resting potassium conductance of isolated guinea pig ventricular cellsQ41922246
Species- and agonist-dependent differences in the deactivation-kinetics of P2X7 receptorsQ43646177
ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels.Q43954485
An enzymatic assay for lysophosphatidylcholine concentration in human serum and plasmaQ44149378
Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptorsQ44517513
Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytesQ46264995
Exogenous lysophosphatidylcholine increases non-selective cation current in guinea-pig ventricular myocytesQ46461650
Identification of a lysophosphatidylserine receptor on mast cells.Q46929883
Potentiation of native and recombinant P2X7-mediated calcium signaling by arachidonic acid in cultured cortical astrocytes and human embryonic kidney 293 cellsQ46970853
Lysophosphatidylcholine induces the production of IL-1beta by human monocytesQ47987190
Opposite modulation of NMDA receptors by lysophospholipids and arachidonic acid: common features with mechanosensitivityQ48355564
Activation by P2X7 agonists of two phospholipases A2 (PLA2) in ductal cells of rat submandibular gland. Coupling of the calcium-independent PLA2 with kallikrein secretion.Q50521928
Hypoalbuminemia increases lysophosphatidylcholine in low-density lipoprotein of normocholesterolemic subjectsQ57791049
Ischemic poison lysophosphatidylcholine modifies heart sodium channels gating inducing long-lasting bursts of openingsQ69364354
Pathophysiological concentrations of lysophosphatides and the slow responseQ70443985
Increased lysophosphatidylcholine content in lesional psoriatic skinQ70861418
Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardiumQ71394505
Effect of sphingosylphosphorylcholine on the single channel gating properties of the cardiac ryanodine receptorQ73169534
Lysophosphatidylcholine triggers intracellular calcium release and activation of non-selective cation channels in renal arterial smooth muscle cellsQ73457826
ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptorsQ73767661
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectlipidQ11367
P304page(s)523-537
P577publication date2007-08-13
P1433published inBritish Journal of PharmacologyQ919631
P1476titleAgonist potency at P2X7 receptors is modulated by structurally diverse lipids
P478volume152

Reverse relations

cites work (P2860)
Q93115123ATP release drives heightened immune responses associated with hypertension
Q38936183Activated microglia in ischemic stroke penumbra upregulate MCP-1 and CCR2 expression in response to lysophosphatidylcholine derived from adjacent neurons and astrocytes
Q35122793Activation and regulation of purinergic P2X receptor channels
Q36825825Allosteric modulation of ATP-gated P2X receptor channels
Q33948890CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells
Q33801926Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.
Q33509374Cloning and pharmacological characterization of the dog P2X7 receptor
Q39708017Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.
Q37401620Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.
Q39956832Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects
Q34680399Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.
Q35214735Lipopolysaccharide inhibits the channel activity of the P2X7 receptor
Q42363539Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation
Q40037039Negative and positive allosteric modulators of the P2X(7) receptor
Q34509716Plasma membrane cholesterol as a regulator of human and rodent P2X7 receptor activation and sensitization
Q36379060Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
Q40235535The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells
Q37142680The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner.

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