An Overview of Structurally Modified Glycyrrhetinic Acid Derivatives as Antitumor Agents

scientific article published on 2 June 2017

An Overview of Structurally Modified Glycyrrhetinic Acid Derivatives as Antitumor Agents is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES22060924
P932PMC publication ID6152714
P698PubMed publication ID28574470

P2093author name stringHui Wang
Meng Chen
Rui Zhao
Xin-Yu Zhang
Bing Xu
Kang Fang
Hai-Min Lei
Peng-Long Wang
Wen-Bo Guo
Meng-Meng Yan
Gao-Rong Wu
Nan-Nan Xue
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A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gammaQ31483885
Natural products: a continuing source of novel drug leadsQ34328933
The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2.Q34558568
Growth inhibitory in vitro effects of glycyrrhizic acid in U251 glioblastoma cell lineQ35090839
18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancerQ35138733
Natural products as sources of new drugs over the period 1981-2002.Q35184693
18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways.Q36067419
Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agentsQ36082434
Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivativesQ36692328
Structure-activity relationship analyses of glycyrrhetinic acid derivatives as anticancer agentsQ37901514
Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells.Q54547055
Preparation of amino acid conjugates of betulinic acid with activity against human melanomaQ77751777
The synthesis of 18beta-glycyrrhetinic acid derivatives which have increased antiproliferative and apoptotic effects in leukemia cellsQ80473192
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Synthesis and Anticancer Activities of Glycyrrhetinic Acid DerivativesQ87259560
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Synthesis and biological evaluation of novel hydrogen sulfide releasing glycyrrhetic acid derivativesQ38792152
Involvement of BID translocation in glycyrrhetinic acid and 11-deoxy glycyrrhetinic acid-induced attenuation of gastric cancer growthQ39022995
18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathwayQ39070051
QSAR and docking based semi-synthesis and in vitro evaluation of 18 β-glycyrrhetinic acid derivatives against human lung cancer cell line A-549.Q39151663
Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivativesQ39250246
18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathwayQ39302074
18β-glycyrrhetinic acid inhibits rotavirus replication in cultureQ39344325
3-Monoglucuronyl-glycyrrhretinic acid is a substrate of organic anion transporters expressed in tubular epithelial cells and plays important roles in licorice-induced pseudoaldosteronism by inhibiting 11β-hydroxysteroid dehydrogenase 2.Q39356990
N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): a novel anticancer glycyrrhetinic acid derivative that targets the proteasome and displays anti-kinase activityQ39480298
18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cellsQ39512103
Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions.Q39530011
18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes.Q39531259
Synthesis and biological evaluation of furoxan-based nitric oxide-releasing derivatives of glycyrrhetinic acid as anti-hepatocellular carcinoma agentsQ39646666
Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid Inhibit Inflammation via PI3K/Akt/GSK3β Signaling and Glucocorticoid Receptor ActivationQ39672220
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponinsQ39886327
18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicityQ39948077
First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agentsQ40007083
2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cellsQ40088710
Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cellsQ40130462
Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells.Q40334281
Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2.Q40347550
Induction of apoptosis with mitochondrial membrane depolarization by a glycyrrhetinic acid derivative in human leukemia K562 cellsQ42237311
Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activityQ42241352
Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agentsQ42718700
The synthesis of glycyrrhetinic acid derivatives containing a nitrogen heterocycle and their antiproliferative effects in human leukemia cells.Q42958718
Downregulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhetinic acid derivatives in leukemia cellsQ43233411
Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophagesQ43509294
On the mechanism of mitochondrial permeability transition induction by glycyrrhetinic acidQ45080258
Carbenoxolone induces oxidative stress in liver mitochondria, which is responsible for transition pore openingQ45242302
Liquorice and hypertension.Q46470149
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecthydrocarbonQ43648
P577publication date2017-06-02
P1433published inMoleculesQ151332
P1476titleAn Overview of Structurally Modified Glycyrrhetinic Acid Derivatives as Antitumor Agents
P478volume22

Reverse relations

cites work (P2860)
Q9033664518-GA-Suc Modified Liposome Loading Cantharidin for Augmenting Hepatic Specificity: Preparation, Characterization, Antitumor Effects, and Liver-Targeting Efficiency
Q4143302418ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts
Q94570106Efficient synthesis of piperazinyl amides of 18β-glycyrrhetinic acid
Q90614421Exploring New Structural Features of the 18β-Glycyrrhetinic Acid Scaffold for the Inhibition of Anaplastic Lymphoma Kinase
Q92641546Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives
Q64255694Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives

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