The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor

scientific article published on 4 May 2012

The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/JMCB/MJS021
P698PubMed publication ID22561840
P5875ResearchGate publication ID224914370

P50authorKwang-Hyun ChoQ67137583
P2093author name stringWon Do Heo
Sung-Young Shin
Jong Hoon Lee
Jae-Kyung Won
Hee Won Yang
P2860cites workMetabolic control analysis: biological applications and insightsQ21194892
Cell signaling by receptor tyrosine kinasesQ24598357
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationQ24616946
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathwayQ24799816
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gammaQ27629132
RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancerQ27657185
MEK1 mutations confer resistance to MEK and B-RAF inhibitionQ27777362
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancersQ27851426
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancersQ27851457
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutationQ27851610
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.Q27851711
Factors underlying sensitivity of cancers to small-molecule kinase inhibitorsQ28252845
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
BRAF mutation predicts sensitivity to MEK inhibitionQ29614281
Phosphatidylinositol-3-OH kinase as a direct target of RasQ29620177
Targeting the cancer kinome through polypharmacologyQ33893019
Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysisQ34101667
A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancerQ34106382
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.Q37196175
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
Environment-mediated drug resistance: a major contributor to minimal residual diseaseQ37582773
Systems-biology approaches for predicting genomic evolutionQ37909892
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancerQ38445646
A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network.Q39617812
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancersQ39859169
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanomaQ39971699
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitorQ40164535
Activation of phosphoinositide 3-kinase gamma by Ras.Q40717916
Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.Q41836780
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cellsQ42478581
High-order combination effects and biological robustnessQ42554339
Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancersQ43136770
A robustness-based approach to systems-oriented drug design.Q51062307
Robustness against mutations in genetic networks of yeast.Q52169621
P433issue3
P304page(s)153-163
P577publication date2012-05-04
P1433published inJournal of Molecular Cell BiologyQ2456339
P1476titleThe crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor
P478volume4

Reverse relations

cites work (P2860)
Q36169826Attractor landscape analysis of colorectal tumorigenesis and its reversion
Q47120750Biocompatibility of vertically aligned multi-walled carbon nanotube scaffolds for human breast cancer cell line MDA-MB-231.
Q39313461Cell type specificity of signaling: view from membrane receptors distribution and their downstream transduction networks
Q33671530Context-independent essential regulatory interactions for apoptosis and hypertrophy in the cardiac signaling network
Q92134153Coupled feedback regulation of nuclear factor of activated T-cells (NFAT) modulates activation-induced cell death of T cells
Q42287113Differential Tissue-specific and Pathway-specific Anti-obesity Effects of Green Tea and Taeumjowitang, a Traditional Korean Medicine, in Mice
Q35612549Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling
Q50538898Dissecting Cell-Fate Determination Through Integrated Mathematical Modeling of the ERK/MAPK Signaling Pathway.
Q64953229Dual Targeting of Y-Box Binding Protein-1 and Akt Inhibits Proliferation and Enhances the Chemosensitivity of Colorectal Cancer Cells.
Q38995370Expression and activity of EGFR in human cutaneous melanoma cell lines and influence of vemurafenib on the EGFR pathway
Q90481923FRA1 contributes to MEK-ERK pathway-dependent PD-L1 upregulation by KRAS mutation in premalignant human bronchial epithelial cells
Q45715391Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs
Q38402255Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells
Q38705548Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments
Q35552019Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells.
Q37665359Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer
Q55122179MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma.
Q92501735Modeling therapy resistance via the EGFR signaling pathway
Q48276915Network-based identification of feedback modules that control RhoA activity and cell migration
Q58024450Oncogenic PI3K/AKT promotes the step-wise evolution of combination BRAF/MEK inhibitor resistance in melanoma
Q35781521Oncogenic mutations of thyroid hormone receptor β.
Q55086907Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells.
Q27852623Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.
Q48236551Protein disulfide isomerase inhibition synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma
Q57050008Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation
Q49378719Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF‑7 cells in vitro and in vivo and its mechanism of action
Q90468026Signal flow control of complex signaling networks
Q37301884Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging
Q55360028Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer.
Q48251105Targeting Insulin-Like Growth Factor-I and Extracellular Matrix Interactions in Melanoma Progression.
Q64247758Tensor clustering with algebraic constraints gives interpretable groups of crosstalk mechanisms in breast cancer
Q54274892The PI3K/AKT/mTOR interactive pathway.
Q39101573The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2.
Q51085252The hidden switches underlying RORα-mediated circuits that critically regulate uncontrolled cell proliferation.
Q38128540The merged basins of signal transduction pathways in spatiotemporal cell biology
Q37208975Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis.

Search more.